Principal Scientist I, Molecular Lab Research and Early Development

The Position We are seeking a Principal Scientist I to join our Molecular Lab, Research and Early Development Team, Oncology and Genetics. The role focuses on building sequencing assays on our revolutionary Axelios Sequencing platform and translating the immense potential of our Sequencing by Expansion (SBX) technology into real‑world assays that can benefit patients. It is a hands‑on, lab‑based position that requires scientific excellence, a proactive, results‑oriented mindset, and the ability to drive projects from concept to fully realized solution. Opportunity You will join a diverse local team of dedicated and curious scientists where you will role‑model leadership qualities, mentor junior scientists, and champion a culture of scientific rigor and innovation. You will prototype and optimize different sequencing assay workflows by aligning pharma project needs, designing and implementing rigorous experiments, and applying established and innovative procedures to enable end‑to‑end solutions; you will proactively highlight issues, troubleshoot assays, and resolve technical challenges by applying broad knowledge of molecular biology techniques and accumulated experience. You will work closely with the commercial team, external pharma partners, and internal bioinformatics colleagues to implement and analyze novel workflows to further pharma collaborations, translating complex data into meaningful interpretations for internal and external stakeholders. You will support the adoption of Axelios sequencing technology and the growth of the pharma service business by executing pilot collaboration projects, creating technical documentation including standard operating protocols, and supporting assay transfer to the CLIA laboratory. You will identify and champion new technological opportunities, contributing to the strategic direction of the R&D organization. This position is based on‑site (4+ days) in Pleasanton, CA. There is no relocation support. Who You Are: (Required) You have a PhD in Bioengineering, Molecular Biology, Genetics, Biochemistry, or a related field with 5+ years of relevant industry experience. You have a deep understanding of molecular biology in NGS workflows beyond routine preparation of sequencing libraries. You have demonstrated experience designing and optimizing novel NGS workflows. You have demonstrated the ability to critically examine assay workflows and troubleshoot unknown and unfamiliar issues. You have experience with diagnostic assay development, including a high level understanding of the regulatory framework for RUO, LDT, or IVD assays. You have demonstrated proficiency in interpreting standard bioinformatics pipeline outputs and sequencing metrics for genomic analysis. You have excellent interpersonal and communication skills, with a proven ability to identify areas of misalignment and collaborate effectively within and across teams. You have excellent organizational skills, including the ability to efficiently evaluate, prioritize and handle multiple changing projects and priorities; you complete work in a timely, accurate and thorough manner. Preferred You have experience beyond standard library preparation from DNA or RNA, such as single‑cell sequencing, protein detection by sequencing, or spatial sequencing. You have experience working with different NGS instruments (e.g. Element, Ultima, Pacbio, Oxford). You have experience with automating sequencing workflow on systems like the Hamilton or Tecan. You have a strong record of innovation, demonstrated by publications and patents. You are proficient in technical writing. The expected salary range for this position is based on the primary location of Pleasanton, CA and is $111,000 - $206,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed below. Benefits Details available upon request. Roche is an equal‑opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to discrimination on the basis of protected veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing the Accommodations for Applicants form. #J-18808-Ljbffr