Senior Manager, Financial Planning & Analysis

Senior Manager, FP&A

Stoke Therapeutics is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary TANGO approach, Stoke is developing antisense oligonucleotides to selectively restore naturally-occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke's initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke's proprietary approach. Stoke is headquartered in Bedford, Massachusetts.

The Senior Manager, FP&A will play an integral role in supporting the Company's financial planning, analysis and close processes, contributing to continued growth. The focus of this position will be playing a key role in the forecasting, budgeting and long-range planning processes, as well as supporting the month-end / quarter-end close processes. This person may also serve as a business partner to select departments. This person will work closely with the FP&A team, Accounting and department heads as needed to understand and support the performance of their respective areas.

This individual will maintain and continuously update, with attention to detail, the Company's existing internal financial model, ensuring it reflects updated budgets, changing business needs and other strategic considerations.

They will provide analytical support to the FP&A team, including preparing Executive Leadership Team (ELT) presentations and assisting with ad hoc analyses and other projects as requested. We are looking for a highly motivated team member who will start in a supporting capacity and have the opportunity to grow into owning parts of these processes over time. The position reports to the Director, FP&A.

Key Responsibilities:

• Support the annual budgeting, quarterly forecasting and long-range planning processes.
• Perform month-end and quarter-end variance analysis. Identify, interpret and explain budget and expense variances: analyze cost variances, actual vs. plan/forecast and actual vs. prior period, review with departments.
• Provide regularly recurring reports that summarize operational results and forecasts, including department performance against financial, strategic and operational targets, with timely communication of opportunities and risks to relevant stakeholders; routinely communicate business, financial, and operational performance trends, historical and forecasted, using appropriate metrics.
• Support the Company's collaborations, including invoicing, collaboration reporting, and ad hoc data requests.
• Partner with select departments as needed to ensure accurate monthly financial reporting and provide ongoing financial and analytical support.
• Support Clinical Operations by reviewing CRO agreements and clinical program reporting, as well as assisting with clinical trial budgeting activities; prior exposure to clinical operations finance is strongly preferred.
• Maintain and update the existing financial model and forecasting models for both planning and accrual recognition, ensuring accuracy and strong attention to detail.
• Prepare Executive Leadership Team (ELT) slides each month and quarter and provide financial support for Board presentation preparation.
• Implement best practices/policies as defined by internal and external guidelines.
• Champion adoption of advanced analytics, automation, AI-enabled forecasting tools, and data visualization capabilities within FP&A.
• Identify opportunities to improve insight generation, reporting efficiency, and forecasting accuracy through technology and process innovation.

Required Skills & Experience:

• B.A. or B.S. degree.
• 5+ years of financial planning and analysis experience with progression demonstrated, preferably within the biopharmaceutical space.
• Advanced Microsoft Excel and PowerPoint skills required.
• Experience with Workday Adaptive Planning and OfficeConnect strongly desired.
• Ideal candidate will have Clinical Operations finance experience including reviewing CRO agreements, supporting clinical reporting processes, and assisting with clinical trial budgeting activities.
• Highly motivated, analytical thinker with strong problem solving skills and the desire to grow into ownership of key FP&A processes.
• Ability to work independently and collaboratively, as required, in a fast-paced environment.
• Strong work ethic and a team player.
• Strong quantitative and financial modeling skills; experience maintaining and updating complex financial models in Excel.
• Superior project management and communication skills, both written and verbal, including the ability to support and prioritize multiple projects.

Location(s): Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a hybrid position, currently based in Bedford and will be based in Waltham starting in January 2027.

Compensation & Benefits: At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $165,000 - $190,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values: At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center: