Senior Staff Engineer, Software

PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team. Position Summary: The Senior Staff Software Engineer is responsible for designing, developing, and delivering business-critical instrument control software for next-generation sequencing platforms. This is a highly visible, cross-functional role that works closely with mechanical, electrical, firmware, and systems engineering teams at PacBio. This role is ideal for a deeply technical engineer who thrives on solving complex system-level challenges and driving high-impact software solutions at the intersection of hardware and software.Responsibilities: Own and deliver business-critical instrument control software spanning multiple subsystems, directly impacting instrument performance, reliability, and customer experienceDrive technical design and implementation for complex, high-risk areas, independently defining approach and managing technical riskCollaborate cross-functionally with mechanical, electrical, firmware, and systems teams to ensure robust hardware-software integration and clear requirementsIdentify and resolve systemic issues in performance, reliability, and scalability, including proactively addressing technical debtLead design and code reviews while contributing hands-on development in C#/.NET, ensuring high-quality, maintainable softwareInfluence system architecture and technical direction, and mentor engineers to elevate team-wide engineering standards Required Qualifications: Bachelor’s degree in Computer Science, Engineering, or a related discipline10+ years of software engineering experienceDeep expertise in C#/.NET and proficiency in PythonStrong experience with real-time or embedded systems and hardware-software integrationExperience working with hardware systems such as robotics, optical systems, environmental sensors, or motion controlStrong proficiency with Linux environmentsSolid understanding of software architecture, design principles, and best practicesExperience developing instrument control software, user interfaces, and system-level integrationsExperience designing and implementing APIs (e.g., RESTful services)Demonstrated ability to independently drive complex technical projects from concept to productionExcellent interpersonal, written, and verbal communication skillsPreferred Experience: Experience developing scientific instrumentationMaster’s degree or higher in a technical fieldExperience working with firmware and low-level system interactions (e.g., FPGA interfaces)Experience with Agile software development methodologiesExperience with DevOps practices, CI/CD pipelines, and automated testing frameworksExperience in life sciences, biotech, medical devices, or other regulated environments Candidates must have current authorization to work in the United States without the need for present or future sponsorship. You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties. All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation. #LI-OnsiteSalary Range:$195,900.00 - $293,900.00To all Staffing and Recruiting Agencies: Our Careers Site is only for individuals seeking a job at PacBio. Staffing and recruiting agencies and individuals being represented by an agency are not authorized to use this site or to submit profiles, applications or resumes, and any such submissions will be considered unsolicited. PacBio does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to our jobs alias, PacBio employees or any other company location. PacBio is not responsible for any fees related to unsolicited resumes/applications.All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at View phone number on click.appcast.io, or View email address on click.appcast.io for assistance.Visit our following pages for more information on:FAQsBenefitsCultureEqual Opportunity EmploymentSummaryLocation: US - California - Menlo ParkType: Full time