Sr. Associate Scientist- Formulation Development

Why Patients Need You Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world. What You Will Achieve This position will be part of Drug Product Design and Development (DPDD) within the Pharmaceutical Research and Development (PhRD) department. The incumbent will participate in the development of parenteral formulation for biologics modalities such as monoclonal antibodies, peptide‑based therapeutics, antibody drug conjugates, proteins, and vaccines. The role involves performing analytical characterization of candidate molecules using various biophysical and biochemical techniques and assisting in developing processes for drug product manufacturing, data compilation, presentations, and report writing. A strong foundation in general scientific practice and the ability to meet critical deadlines will be essential. How You Will Achieve It Participate in developing parenteral formulations for biotherapeutic modalities such as monoclonal antibodies, peptide–based therapeutics, antibody drug conjugates, proteins and vaccines; assist in developing manufacturing processes under general supervision. Perform rapid, comprehensive characterization of candidate molecules to determine the stability profile and apply this information to develop an appropriate dosage form to meet clinical needs using biophysical and biochemical techniques such as UPLC (SE‑UPLC, IEX, RP‑UPLC), SDS‑PAGE, LC‑MS, Capillary Gel electrophoresis (CGE), imaged Capillary Electrophoresis (iCE), UV and Fluorescence spectroscopy, Circular Dichroism and FTIR. Assist in the development and scale‑up of drug product processes from bench top to pilot scale and, as required, technology transfer to commercial plants (e.g., fluid transport, sterilizing filtration and lyophilization). Collaborate effectively with a multi‑disciplinary team of scientists for formulation optimization and overall candidate progression. Prepare data summary presentations, compile data, and author technical reports. Demonstrate effective communication skills for interactions with laboratory scientists, project managers and colleagues across functions, serving on multi‑disciplinary project teams. Qualifications B.S. in Biochemistry, Chemical/Biochemical Engineering, Pharmacy, Chemistry, Biology, or equivalent with a minimum of 2 years’ relevant industry experience. Ability to follow established procedures independently. Working knowledge of SE‑UPLC, RP‑UPLC, LC‑MS, peptide mapping, UPLC (IEX), SDS‑PAGE, Capillary Gel electrophoresis (CGE), imaged Capillary Electrophoresis (iCE), and spectroscopy techniques. Experience with biotherapeutics analytical methods such as UPLC (IEX), SDS‑PAGE, Capillary Gel electrophoresis (CGE), imaged Capillary Electrophoresis (iCE), and spectroscopy techniques. Demonstrated scientific documentation skills. Preferred Qualifications M.S. Degree in an above field and 0‑2 years of experience preferred. Experience with drug development of biologics and vaccines. 2‑4 years of hands‑on lab experience in analytical techniques. Excellent documentation skills. Self‑motivated and highly effective in a team‑based environment. Effective written and oral communication skills. Familiarity with GMP requirements. Familiarity with parenteral manufacturing requirements, container/closure integrity, and clinical and commercial unit operations. Practical knowledge of lyophilization and lyophilization cycle development. Physical/Mental Requirements Lab‑based position requiring standing and working in a lab and operating analytical and formulation instruments and equipment. Non‑standard Work Schedule, Travel Or Environment Requirements Occasional travel required to support project work or training. Salary and Benefits The annual base salary for this position ranges from $68,600.00 to $114,300.00. The position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. Benefits include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits (medical, prescription drug, dental and vision coverage). Relocation assistance may be available based on business needs and/or eligibility. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E‑Verify employer. This position requires permanent work authorization in the United States. U.S. work visa sponsorship is not available for this role now or in the future. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. Those payments may be reported under the Sunshine Act. If you are a licensed physician who incurs recruiting expenses that we pay or reimburse, your name, address and the amount of the payments will be reported to the government. #J-18808-Ljbffr Pfizer