Research Scientist II

Research Scientist II

A Research Scientist II position is available in the laboratory of Professor Alexander Adibekian in the Department of Chemistry and Biochemistry at the University of Texas at Dallas. We are seeking a specialist in cell biology and preclinical pharmacology to lead the biological validation arm of the laboratory's target discovery program.

The laboratory applies chemoproteomic and chemical biology approaches to identify the protein targets of bioactive natural products and covalent small molecules. The successful candidate will translate the targets emerging from these platforms into cell-based and in vivo systems: generating engineered and reporter cell lines, designing target-engagement and mechanism-of-action assays, and establishing preclinical tumor models to evaluate candidate compounds and inform the development of new therapeutic leads.

Minimum Education and Experience - A minimum of a PhD in a field directly related to research and a minimum of two years of experience/expertise as noted below.

Preferred Education and Experience - We are looking for an enthusiastic and ambitious scientist excited to work in a highly interactive and motivated research environment.

Essential Duties and Responsibilities - Plan, conduct, and direct a wide variety of experiments in cell-based and in vivo systems. Design and execute biological validation studies for protein targets identified by the laboratory's chemoproteomic platforms. Establish, maintain, and execute preclinical rodent models, including colony management, breeding, genotyping, dosing, in vivo imaging, and endpoint analysis, in compliance with IACUC and institutional requirements. Develop and optimize imaging and quantitative image analysis workflows; conduct experiments using advanced equipment and applying complex techniques, methods and procedures. Be responsible for the evaluation and interpretation of research data. Develop research protocols and supervise graduate or undergraduate researchers. Prepare written reports and contribute to the writing of research articles and grant applications.