Process Scientist

SiPhox Health is building a first-of-its-kind consumer diagnostics platform that brings complex biochemical analysis into the home through integrated silicon photonics, microfluidics, embedded systems, and advanced assay development. We are building an ambitious, multiplexed clinical-grade immunoassay menu on our at-home diagnostics platform and are seeking a Process Scientist with surface chemistry expertise, a can-do attitude, logical reasoning, and meticulous attention to detail. This is a rare opportunity to join a high-growth startup at its first major inflection point — with a validated, first-generation platform ready for commercialization and scale-up, alongside active next-generation development. You will play a critical role in driving both research and commercialization of our diagnostic devices, operating with a high degree of independence while collaborating cross-functionally across the organization. What You’ll Own Surface Chemistry & Assay Development Design, develop, and evaluate novel surface chemistry approaches to enable immunoassay applications. Design and evaluate novel surface chemistry solutions on microfluidic and lab-on-chip devices, with a strong understanding of how device geometry and flow conditions influence surface performance and assay outcomes. Troubleshoot performance issues related to surface fouling and non-specific binding. Identify and resolve experimental challenges related to assay design, protocol execution, reagent selection, and surface performance. Product & Process Development Define and lead product development efforts, including experimental design, prototyping, functional testing, and data analysis. Support the transfer of surface chemistry solutions from research into product development and manufacturing, in close collaboration with process development and operations teams. Contribute innovative ideas and technical insight to early-stage concept development and feasibility assessments. Maintain hands-on scientific leadership, setting the direction for laboratory experimentation and troubleshooting while mentoring junior scientists and guiding their technical development. Collaborate effectively with colleagues in product management, assay development, engineering, and manufacturing to ensure alignment and successful execution. Contribute technical expertise to invention disclosures and patent applications, in collaboration with the IP legal team and senior technical leadership. Prepare and deliver high-quality technical reports and presentations that summarize findings, support decision-making, and document development progress. And any other assigned duties as determined by leadership. What We’re Looking For Required Qualifications PhD in Chemistry, Materials Science, Biochemistry, Bioengineering, Physics, or a closely related field. 6+ years of relevant industry experience in surface chemistry, materials science, or biomolecular interfaces within life sciences or diagnostics. Deep expertise in surface chemistry, polymer chemistry, and biomolecule–surface interactions. Strong publication and presentation record, with contributions to patents or novel methodologies. Ability to operate with a high degree of independence in experimental planning, execution, and data interpretation, requiring minimal day-to-day supervision. Strong scientific judgment to extrapolate from existing expertise and address novel or ambiguous technical challenges. Proactive mindset to identify risks, knowledge gaps, and opportunities, and to propose data-driven paths forward that shape project scope and organizational priorities. Clear, purposeful communication across disciplines to enable alignment, informed decisions, and efficient collaboration. Authorization to work in the U.S. without sponsorship. Preferred Qualifications Familiarity with microfluidic device design principles, including channel geometry, surface-to-volume ratios, and flow dynamics; experience with device fabrication or commercial lab-on-chip platforms is a plus. Familiarity with surface analytical techniques such as AFM, ellipsometry, FTIR, SEM, TOF-SIMS, and XPS. Familiarity with manufacturing constraints, process transfer, or scale-up. KPIs (Success Measures) Experimental throughput and quality — number of well-controlled, documented experiments completed per quarter; reproducibility and scientific rigor of results. Assay and surface chemistry milestones — on-time delivery of defined development milestones (e.g., achieving target binding performance, completing process transfers). Cross-functional collaboration — quality and timeliness of technical documentation, presentations, and knowledge transfer to manufacturing and product teams. Innovation contribution — invention disclosures, patent applications, or novel methodologies introduced. Who Thrives Here You thrive in fast-paced, highly collaborative environments where priorities evolve quickly. You set ambitious goals and consistently deliver outstanding, measurable results. Youact with absolute personal integrity, humility, and a passion for excellence in both science and execution. You’re a calculated risk-taker who challenges conventional solutions and approaches problems from first principles. Why Join SiPhox Health Help bring a first-of-its-kind at-home diagnostics platform to market. Work alongside multidisciplinary engineering and scientific teams solving complex technical challenges. Opportunity for expanded scientific leadership responsibilities as the organization scales. Competitive compensation, equity, and benefits (including Lifetime Fitness membership). Department: Research & Development / Assay Development Work location: Burlington, MA (on-site) Salary Range: $120,000 to $168,000 401K Health Insurance Vision Insurance Health Savings Account Health Flexible Savings Account Dependent Care Flexible Savings Account Life Insurance Paid Time Off Long Term Disability Equity Gym Membership (Lifetime Fitness — one block from the office) Physical Requirements Ability to lift up to 20 pounds. This role involves physical activity and routine handling of chemicals. Candidates must adhere to all laboratory safety protocols and be comfortable using appropriate personal protective equipment (PPE). Equal Opportunity Employer SiPhox Health is an equal opportunity employer committed to building an inclusive workplace. Applicants of all backgrounds and experiences are encouraged to apply. #J-18808-Ljbffr