Principal Scientist - Chemical Biology & Proximity-Based Therapeutics
Amgen Inc
This Principal Scientist role leads discovery efforts within Amgen's Induced Proximity Platform, focusing on molecular glue discovery and proximity-based therapeutics. The position combines phenotypic screening, chemical genetics, and mechanistic biology to identify novel therapeutic opportunities targeting previously difficult-to-drug proteins. Success requires designing cellular models, building screening assays, and collaborating across teams to advance discoveries toward early-stage drug development.
Responsibilities
- Lead discovery efforts using phenotypic screening and chemical genetics to identify novel proximity-driven mechanisms
- Develop and apply disease-relevant cellular models to uncover actionable biology and capture functional outcomes
- Design and implement phenotypic screening strategies to enable molecular glue and proximity-based modulator discovery
- Build and optimize high-content and high-throughput assays with imaging-based and multi-parametric readouts
- Partner with cross-functional teams to advance discoveries from screening through early drug discovery stages
Requirements
- Doctorate in chemical biology, cell biology, biochemistry, pharmacology, or related field with 2+ years industry experience
- OR Master's degree in relevant life sciences field with 5+ years industry experience
- OR Bachelor's degree in relevant life sciences field with 7+ years industry experience
- Expertise in chemical biology and small molecule discovery with proximity-based mechanisms experience
- Demonstrated experience developing and executing phenotypic screening assays including high-content platforms
- Strong background in mechanism-of-action studies using cellular and molecular biology approaches
- Proven ability to integrate biology and chemistry to drive discovery efforts
Vacancy posted a month ago
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