Senior Clinical Informaticist
Mosai
About Mosai
Mosai™ is the intelligent care coordination platform that brings together the fragmented pieces of healthcare into a clear, connected picture. Like a mosaic, our platform unites data, people, and processes so providers can make better decisions, coordinate care in real time, and deliver improved outcomes. With Mosai, home-based care organizations can thrive in value-based care while giving every patient the right care, in the right place, at the right time. Learn more at
Position Summary
Mosai is looking for a Senior Clinical Informaticist to be the clinical conscience of its AI and help drive AI-assisted health care at home. Working with data scientists and ML engineers, this person will own the clinical ground truth used to train and evaluate models, including what gets labeled, how it gets labeled, and whether outputs are safe and correct for nurses, therapists, and hospice teams to use.
As the first hire in the clinical informatics function, this hands-on senior leader will create annotation guidelines, label and adjudicate data, build gold-standard datasets, and lead clinical evaluation of models and LLM-based features. The role brings knowledge of how care is delivered and documented at home into the data and logic used by Mosai's AI, while helping build the clinical informatics team.
Job Duties:
- Own clinical annotation: design labeling schemas and versioned guidelines for clinical notes, OASIS items, diagnoses, medications, wounds, functional status, and other home health and hospice concepts.
- Label and adjudicate data directly; engage appropriate in-house clinical resources, resolve annotator disagreements, make final clinical calls on edge cases, and build and maintain core gold-standard datasets for data science models.
- Work with MLOps and data science teams to report and monitor model performance and respond to drift in key accuracy metrics.
- Measure inter-annotator agreement using standard metrics, such as Cohen's or Fleiss' kappa; run calibration sessions, audit samples, and improve annotation guidelines and workflows.
- Evaluate model predictions and LLM-generated text for accuracy, completeness, hallucination, bias, and clinical safety.
- Design evaluation rubrics and help define clinical criteria for release of traditional ML and LLM-based models.
- Translate home health and hospice workflows, including start of care, recertification, resumption of care, discharge, hospice admission, and IDG, into structured data, rules, and features.
- Map clinical concepts to ICD-10-CM, SNOMED CT, LOINC, RxNorm, OASIS, and hospice HOPE data elements; support EHR integration, including HomeCare HomeBase, using HL7 and FHIR.
- Define clinical data quality checks, document provenance and dataset versions, and apply HIPAA, minimum-necessary, and de-identification practices to labeling work.
- Support development of AI capabilities by demonstrating how skilled clinicians perform the same tasks.
- Partner with product and engineering on clinical requirements, pre-release validation, post-release model monitoring, and clinician feedback loops.
- Recruit, train, and mentor clinical annotators and junior informaticists as the program grows.
Minimum Requirements
- Active, unrestricted clinical license as an RN (BSN or equivalent), Physical Therapist, Occupational Therapist, or Speech-Language Pathologist.
- At least five years of clinical experience, including meaningful time in home health and/or hospice.
- At least four years in clinical informatics, such as informatics nursing, clinical analysis, clinical data abstraction, or quality, aligned with recognized standards such as the ANA Nursing Informatics Scope and Standards of Practice or AMIA health informatics core competencies.
- Core informatics competencies in clinical workflow analysis, data governance and quality, the system lifecycle (requirements, testing, validation, and go-live), and clinical decision support or quality measure logic.
- Working understanding of how traditional supervised and unsupervised machine learning and LLM-based models are trained and refined.
- Hands-on OASIS expertise, including the current OASIS-E data set and guidance manual.
- Working knowledge of ICD-10-CM coding and home health payment and quality programs, including PDGM, HHVBP, and Home Health Quality Reporting.
- Experience with clinical data labeling, annotation, or chart abstraction, ideally supporting machine learning or analytics teams.
- Comfort with clinical terminologies, including SNOMED CT, LOINC, and RxNorm.
- Working knowledge of HIPAA and PHI de-identification methods, including Safe Harbor and Expert Determination.
- Precise, consistent judgment and ability to explain clinical reasoning clearly to non-clinicians.
Work Environment
- This position is open to applicants who currently reside in, or are willing to work from, one of the following states: FL, GA, IA, IN, KY, MI, MO, MS, NC, NE, NM, PA, SC, TN, TX. The Company reserves the right to update the list of eligible states at any time. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic information, veteran status, or any other characteristic protected by applicable federal, state, or local law.
Preferred Skills and Experience
- Informatics certification, such as ANCC Informatics Nursing (NI-BC, formerly RN-BC), HIMSS CPHIMS or CAHIMS, AMIA ACHIP, or AHIMA CHDA.
- Master's degree in nursing informatics, health informatics, or data science.
- Home health certification, such as COS-C, HCS-D, or HCS-O.
- Experience evaluating LLM output, building evaluation rubrics, or conducting clinical red teaming.
- Familiarity with responsible AI practices in health care, including bias and fairness testing, human-in-the-loop review, and model documentation.
- Experience with annotation tools, such as Label Studio, Prodigy, or Labelbox, and basic SQL or Python.
- Experience with HomeCare HomeBase or another home health or hospice EHR.
- Familiarity with hospice documentation and quality reporting, including HOPE, HQRP, and CAHPS Hospice.
Physical Demands of Our Work Environment
- This position uses a computer and other office equipment as needed to perform duties. The in-office noise level in the work environment is typical of that of an office. Frequent interruptions may be encountered throughout the workday.
- The employee is required to either stand or sit, talk and hear frequently required to use repetitive keying or hand motions.
- The physical demands are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
**Be aware of employment fraud. All email communications from Mosai or its hiring managers originate from @mosai.com or addresses. We will never ask you for payment or require you to purchase any equipment. If you are suspicious or unsure about the validity of a job posting, we strongly encourage you to apply directly through our website.
Mosai is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, and disability, or other legally protected status, If you are unable to submit an application because of a incompatible assistive technology or disability, please contact us at View email address on click.appcast.io. We will make every effort to respond to your request for disability assistance as soon as possible.
Mosai is an E-verify employer. Your eligibility to work in the United States will be verified through the E-verify system if you apply and are selected for a position.
$86.4k
...scholarly research and addressing healthcare business challenges. Leveraging experience in and knowledge of clinical, technology, and data subject areas, the informaticist will play a crucial role in the design and development of fit-for-purpose research databases (or data...SeniorFor contractorsWork at officeLocal area- ...solutions that fuel answers, technology that advances performance, and clinical expertise that builds trust to create a more efficient path to... ...domain expertise, Commence cuts straight to better care. The Senior Quantitative Researcher, Alternative Payment Model...SeniorRemote work
- ...solutions that fuel answers, technology that advances performance, and clinical expertise that builds trust to create a more efficient path to... ...domain expertise, Commence cuts straight to better care. The Senior Quantitative Researcher , Alternative Payment Model Monitoring...SeniorRemote workShift work
- ...CenterWell Senior Primary Care is seeking an experienced Center Administrator/Manager to plan and direct outpatient clinical operations. The role emphasizes staffing, policies, and collaboration with clinicians to ensure high-quality patient care and efficient service...Senior
$110.95k - $163.2k
...Work Shift Multiple shifts available Overview: Overview The Senior IT Specialty Analyst is responsible for the day-to-day support,... ..., optimization, and enhancement of Epic applications across Clinical, Revenue Cycle, and Access areas. This role applies advanced...SeniorFull timeTemporary workRemote workShift work$41.1 - $61.65 per hour
...candidate must reside in NC or SCPay Range: $41.10 - $61.65The Senior Statistician serves as a key collaborator at Atrium Health Levine... ...teams, this position provides biostatistical expertise for clinical trials and observational studies throughout the research lifecycle...SeniorDaily paidFull timeTemporary workPart timeWork at officeRemote workShift work$78k - $156k
...products and with staff education, in-services and technical troubleshooting.Execute on a per account basis an EP development and clinical staffing entry and exit strategy.Elevation of local clinical team through AAA execution and mentorship.Provide full post case debrief...SeniorWork at officeLocal areaWeekend work$41.1 - $61.65 per hour
...position, but candidate must reside in NC or SC 41.10 - $61.65 The Senior Statistician serves as a key collaborator at Atrium Health... ...research teams, this position provides biostatistical expertise for clinical trials and observational studies throughout the research...SeniorDaily paidFull timeTemporary workPart timeWork at officeRemote workFlexible hoursShift work- ...members, customers and the communities that we serve through our Healthsource blog: . Clinical Pharmacist, Trend Management Strategies and Programs Premera is seeking a Senior Clinical Pharmacist to lead trend management, affordability strategy, and clinical program...SeniorWork experience placementLocal area
$35.5 - $53.25 per hour
...discussion and interpretation. Develops simple to complex reports utilizing various Business Intelligence tools. Educates clients in clinical and financial operational concepts and their relationship to data. Consults with clients to create methods to quantify key...SeniorDaily paidFull timeTemporary workPart timeWork at officeRemote workRelocationMonday to FridayFlexible hoursShift workDay shift$154.85k - $189.26k
...ways in which we’re different and the same – enabling all individuals to achieve their full potential. Why We Need You: The Senior Data Scientist - Actuarial position is responsible for conducting complex actuarial and predictive analysis to support product development...SeniorFull timeTemporary workPart timeWork experience placementImmediate startWork from homeFlexible hours- ...Job Title: Senior AWS Data Engineer Experience: 8+ Years Skills: AWS Glue, Lambda, Pyspark, Python Location: Fort Mill, SC Job Description : Develop migration workflows based on the approved metadata extraction design. Implement support for full...SeniorFull time
- ...for a CRA/Sr CRA in the US. Oncology Experience required. Cell therapy experience is strongly preferred. Job Purpose: The Clinical Research Associate (CRA) has local responsibility for the delivery of the studies at allocated sites and is an active participant...SeniorLocal areaRemote workFlexible hoursShift work
$118.9k - $230.5k
...the communities that we serve through our Healthsource blog: . About the role of Sr. Clinical Pharmacist, Trend Management Strategies and Programs Premera is seeking a Senior Clinical Pharmacist to lead trend management, affordability strategy, and clinical...SeniorFull timeWork experience placementLocal area$79.1k - $158.2k
...Job Description Responsible for driving the client through the design of clinical and business processes, solution and technology workflow, and successful adoption that will lead to achieved value. Manage ongoing relationships with clients, providing account management...SeniorTemporary workFlexible hours$83.43k - $222.48k
...something bigger – helping to simplify health care one person, one family and one community at a time. Position Summary The Senior Data Engineer will be responsible for delivering high quality modern data solutions through collaboration with our engineering, analysts...SeniorHourly payFull timeTemporary workLocal area$145k - $170k
...Reporting to VP, Analytics & Data Science, the Senior Data Scientist, Product Analytics will provide critical insights to business partners and strategic support to the executive team. You’ll have a significant impact on our product strategy with your high quality data...SeniorFull timeTemporary workRemote workWork from homeHome officeFlexible hours$99k - $225k
Data Scientist, SeniorThe Opportunity: As a data scientist, you’re excited at the prospect of unlocking the secrets held by a data set, and you’re fascinated by the possibilities presented by IoT, machine learning, and artificial intelligence. In an increasingly connected...SeniorFull timeContract workPart timeLocal areaRemote work- ...Senior Data Engineer Fort Mill, SC Responsibilities: Design, develop, and maintain ETL processes to extract, transform, and load data from various sources into Snowflake. Utilize AWS services such as Airflow and Glue for orchestration and data processing tasks...SeniorFull time
- ...Advocate Health, supporting Atrium Health Levine Cancer, seeks a Senior Statistician to collaborate with multidisciplinary cancer research teams. The role involves applying biostatistical methods across the research lifecycle, including study design, data analysis, interpretation...SeniorRemote work
$124k - $280k
...of AI, GenAI, and ML solutions tailored to the complex needs of health system and health plans. As a Senior Manager, you will drive use case development across clinical decision support, population health risk stratification, clinical research, and operational efficiency...SeniorFull timeH1b- ...Job Description Job Description Senior Clinic Manager - Physical Therapist (Full-Time) Bluffton, SC ** Must travel to Hilton Head, Bluffton and Beaufort. Will go to Savannah for occasional meetings. 30 hours of treatment required** Grow Your Career. Make a Difference...SeniorFull timeRelocation packageFlexible hoursAfternoon shiftEarly shift
$132k - $186k
...As part of our Medical Affairs team, you'll foster internal and external collaboration to generate and disseminate evidence-based clinical practices to help impact patient lives and advance the quality of care. Your scientific curiosity and passion for patients will help...Full timeRemote work- ...Senior Data Scientist Company: Norstella Location: Remote, United States Date Posted: Oct 8, 2026 Employment Type: Full Time Job ID: R-2091 Description About Norstella Norstella is a group of prominent pharmaceutical solutions providers – Evaluate...SeniorFull timeTemporary workLocal areaRemote workFlexible hours
- Position Summary We are seeking an experienced Data Engineer to design, build, and enhance data ingestion pipelines and metadata frameworks that support data lineage, modernization, and analytics enablement. The ideal candidate has hands-on experience with AWS...Senior
- ...Description: The Senior Data Engineer, leads the design and implementation of robust data solutions across multiple domains, driving technical excellence and scalability. This role mentor others, shape best practices, and influence data architecture. This role is expected...Senior
- ...Senior Data EngineerSenior Data Engineer opportunity with a healthcare organization seeking a hands-on data professional with strong SSIS, SQL Server, ETL/ELT, data warehousing, and API integration experience. This role will focus on building, maintaining, and troubleshooting...SeniorRemote work
$106.52k - $157.27k
...VA Work Shift First (Days) Overview: Sentara is hiring a Senior Healthcare Data Analyst! This position is fully remote. Overview... ...domains. Ability to communicate findings clearly with operational, clinical, finance, or executive stakeholders. We provide market-...SeniorFull timeTemporary workRemote workShift work- ...including but not limited to Legal counsel Compliance Informatics clinical personnel and IS build teams. The Team L ead for EHR is... ...authorization of all newly hired employees. For further information about the E-Verify program please click here: Experience: Senior IC...SeniorFull timeWork experience placementShift work
- .... Data is foundational to how we serve patients, empower operators, and enable smarter decision-making across the business. As the Senior Manager, Data Engineering, you will lead the strategy, architecture, and execution of Alto’s data platform — ensuring that high-quality...SeniorFull timeTemporary workWork experience placementRemote workFlexible hours
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Senior Clinical Informaticist. Be the first to apply!
- computer scientist South Carolina
- senior devops engineer remote South Carolina
- senior implementation engineer South Carolina
- remote senior project manager South Carolina
- senior payroll accountant South Carolina
- senior purchasing analyst South Carolina
- legal senior counsel family office South Carolina
- senior manager accounts payable South Carolina
- senior human factors engineer South Carolina
- senior business manager South Carolina





