IN-DOH-NGS Specialist

Molecular Biologist

Incumbent is responsible for coordinating and performing the full range of molecular biological examinations and analyses, recording, interpreting, and result reporting of tests on specimens which may include human body fluids, tissues (human and animal), isolates from clinical specimens, and environmental samples to the submitting physician, clinic, hospital, or public health agency. Incumbent is also responsible for the development, validation, and implementation of new molecular tests, preparation of validation documents and SOPs, and troubleshooting of the existing molecular tests. Special emphasis for this position will be around genomic sequencing, maintenance of instrumentation for sequencing, and troubleshooting sequencing assays.

Incumbent will have in-depth knowledge and ability in the areas of molecular biology and is able to perform laboratory associated assays or the ability to learn these techniques upon successful completion of proficiency testing. Representative duties include:

• Extraction of nucleic acids from specimens, isolates, and samples via a variety of manual and automated methods;
• Utilize molecular techniques such as, but not limited to, PCR, MALDI-TOF, and NGS;
• Participate in the evaluation, development, validation, and implementation of new testing methods used in clinical/reference laboratory work, as well as, preparation of validation documents and SOPs;
• Provide technical oversight of the daily performance of high complexity testing; strictly following the laboratory's procedures for specimen handling and processing, test analyses, reporting, and maintaining records of test results;
• Maintain laboratory record system of submitted samples and specimens and their possible referral;
• Evaluate, interpret, validate laboratory results, and report findings;
• Conduct quality control checks on laboratory methods, materials, and equipment;
• Document all quality control activities, instrument calibrations, and maintenance performed;
• Participate in evaluation of new products used in clinical/reference laboratory work;
• Perform all related work as required.

Testing personnel responsibilities include specimen processing, test performance, and reporting test results. Each individual must follow laboratory procedures for specimen handling, test analyses, reporting, and maintaining records of patient test results. They must also adhere to the laboratory's quality control policies, document all quality control activities, instrument and procedural calibrations and maintenance performed, and follow the laboratory's established policies and procedures whenever test systems are not within the laboratory's established acceptable levels of performance.

Job requirements include extensive knowledge of the principles, theories and practices of molecular biology, experience with Next Generation Sequencing platforms, technologies, and procedures, specialized knowledge of current scientific methods and testing procedures, ability to use a full range of standard technical equipment, complex scientific apparatus, and automated techniques of analysis, extensive knowledge of laboratory safety practices and principles, awareness of state and federal laws, rules, regulations, and policies concerning the program area, ability to meet requirements for personnel certification as a technologist pursuant to the Clinical Laboratory Improvement Act (CLIA), ability to effectively communicate technical information both verbally and in writing and maintain productive working relationships, ability to satisfactorily participate in proficiency testing programs and recognize QA problems, and ability to compile, analyze, evaluate, and prepare laboratory reports.

Incumbent works independently as an expert in the Biothreat laboratory. Technical and/or detailed instruction is provided only upon request when a procedural change and/or special project necessitates it. Incumbent maintains established safety practices when working with materials that have a chemical hazard or biohazard potential. Reports are reviewed for general technical accuracy; however, tasks are performed independently. Errors in work could adversely affect the health, safety and well being of the incumbent or coworkers.

Incumbent works with supervisor and with other Department of Health staff such as Laboratory Safety Officer and/or external entities (e.g. local health departments, etc.) to devise and implement work procedures and information dissemination. Individual will have contact with employees and the public as a laboratory expert and in the explanation of laboratory procedures and recommendations when appropriate. This position will be required to use all appropriate personal protective equipment in the designated laboratory area. The equipment can be cumbersome and awkward; the laboratory space can experience a dramatic increase in temperature. The incumbent will be required to work in these conditions and maintain a clear thought process during the testing.