Principal Machine Learning Scientist
$142.8k - $274.8kMicrosoft
Job ID: 200055309Posted: 2026-09-14Location: United States, Washington, RedmondSalary: USD $142,800 - $274,800 per yearEmployment type: Full-TimeWork site: 3 days / week in-officeRole type: Individual ContributorTravel: Less than 25%Profession: Research, Applied, & Data SciencesDiscipline: Data ScienceCompany: MicrosoftOverviewThe Data Science & Applied AI (DSAAI) organization within Commerce Engineering & AI (CEAI) is leading Microsoft's transformation into an AI-native enterprise. Our mission is to combine advanced machine learning, Generative AI, agentic systems, and applied science to power intelligent experiences across Microsoft's commercial, sales, customer success, support, and business operations ecosystems. We are looking for a Principal Machine Learning Scientistto lead the development of next-generation AI systems, including large language models, AI agents, recommendation systems, predictive analytics, evaluation platforms, and AI-driven decision intelligence solutions. This role requires deep expertise in machine learning science, Generative AI, AI-native development methodologies, experimentation frameworks, and large-scale production systems. The successful candidate will drive technical strategy, influence engineering and product roadmaps, mentor scientists and engineers, and deliver measurable business impact across CEAI. Microsoft’s mission is to empower every person and every organization on the planet to achieve more. As employees we come together with a growth mindset, innovate to empower others, and collaborate to realize our shared goals. Each day we build on our values of respect, integrity, and accountability to create a culture of inclusion where everyone can thrive at work and beyond. ResponsibilitiesKey Responsibilities: ML/AI Strategy & Technical Leadership: Define and drive the scientific vision for AI and machine learning initiatives across CEAI. Influence technical strategy and roadmap decisions across multiple product and platform teams. Serve as a trusted advisor to engineering, product, and executive leadership. Lead cross-organizational initiatives involving AI platforms, model development, evaluation systems, and business intelligence capabilities. Mentor scientists and engineers while establishing scientific and engineering best practices. Model Operationalization: Implement CI/CD pipelines for ML models, ensuring smooth deployments with minimal downtime. Design and deploy robust monitoring and alerting systems for ML models in production to detect issues such as model drift or data skew. Implement model governance, version control, and logging systems to ensure compliance with internal standards and external regulations. AI-Native AI/ML Development: Design and develop AI-native experiences leveraging Large Language Models (LLMs), AI agents, copilots, retrieval systems, and autonomous workflows. Lead development of agentic systems utilizing tool orchestration, memory architectures, reasoning frameworks, and multi-agent collaboration. Drive adoption of AI-assisted and AI-native ML development practices. Establish evaluation-driven development methodologies that continuously measure quality, relevance, usefulness, safety, and business impact. Operational Excellence: Partner with cross-functional teams, including Data Engineering, Product Management, and other Engineering teams to build cohesive solutions. Provide technical guidance to engineers and drive best practices for MLOps within the team. Partner with engineering teams to productionize ML/AI solutions at MCAPs at scale Drive adoption of modern ML practices. Security & Compliance: Work on securing models, data pipelines, and infrastructure in compliance with Microsoft's security standards. Ensure that the entire ML lifecycle adheres to privacy and compliance requirements (e.g., GDPR, CCPA). QualificationsRequired/minimum qualificationsDoctorate in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 3+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results) OR Master's Degree in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 5+ years data-science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results) OR Bachelor's Degree in Data Science, Mathematics, Statistics, Econometrics, Economics, Operations Research, Computer Science, or related field AND 7+ years data science experience (e.g., managing structured and unstructured data, applying statistical techniques and reporting results) OR equivalent experience.Other RequirementsAbility to meet Microsoft, customer and/or government security screening requirements are required for this role. These requirements include but are not limited to the following specialized security screenings: Microsoft Cloud Background Check. This position will be required to pass the Microsoft Cloud background check upon hire/transfer and every two years thereafter. Preferred Qualifications10+ years developing and deploying machine learning solutions in production. 5+ years leading large-scale AI or machine learning initiatives. Experience delivering measurable business impact through applied science. Experience in machine learning, deep learning, statistical modeling, and experimentation. Experience with Large Language Models and Generative AI technologies. Experience building production AI systems using Azure AI, Azure OpenAI, Azure Machine Learning, or similar platforms. Proficiency in Python and modern ML frameworks including PyTorch, TensorFlow, Hugging Face, Semantic Kernel, AutoGen, LangGraph, or equivalent. Experience designing and evaluating agentic AI systems and AI-native applications. Experience with MLOps, LLMOps, model governance, and AI observability. Experience building enterprise copilots, AI agents, or autonomous workflows at scale. Experience with AI evaluation platforms, benchmarking systems, and model quality measurement frameworks. Experience with Sales Intelligence, Commercial Operations, Customer Success, Commerce Systems, Business Applications, Revenue Optimization, Customer Insights Experience patents, publications, open-source leadership, or notable technical innovation. Experience leading AI transformation initiatives within large organizations. AI-native operating models and human-AI collaboration patterns experience. #CEAIjobsData Science IC5 - The typical base pay range for this role across the U.S. is USD $142,800 - $274,800 per year. There is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $188,000 - $304,200 per year. Certain roles may be eligible for benefits and other compensation. Find additional benefits and pay information here:This position will be open for a minimum of 5 days, with applications accepted on an ongoing basis until the position is filled.Microsoft is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to age, ancestry, citizenship, color, family or medical care leave, gender identity or expression, genetic information, immigration status, marital status, medical condition, national origin, physical or mental disability, political affiliation, protected veteran or military status, race, ethnicity, religion, sex (including pregnancy), sexual orientation, or any other characteristic protected by applicable local laws, regulations and ordinances. If you need assistance with religious accommodations and/or a reasonable accommodation due to a disability during the application process, read more about requesting accommodations.
$142.8k - $274.8k
...Responsible AI, Azure OpenAI, Model as a Service, Azure Machine Learning (ML), Cognitive Services, and the global Azure AI infrastructure... ...GitHub Copilot and Azure OpenAI. We are looking for a Principal Applied Scientist to join our team!Microsoft’s mission is to empower every...PrincipalOngoing contractWork at officeLocal areaShift work3 days per week$142.8k - $274.8k
...Advertising stakeholders. The system integrates advanced machine learning models with emerging agentic capabilities powered by... ...streamline workflows across organizational tools. As a Principal Applied Scientist, you will define scientific vision and lead the development...PrincipalOngoing contractWork at officeLocal areaImmediate start- WSP in the United States seeks a Senior Principal Geologist / Senior Technical Manager to lead site investigation and remediation efforts in the Pacific Northwest. Based in Redmond, WA or Portland, OR, you’ll drive technical excellence, guide MTCA/CERCLA/RCRA programs,...Principal
- ...—it will reason, plan, adapt, and act autonomously.As a Principal Applied Scientist, you'll help invent that future.You will lead the research... ...—this is the role for you.About the TeamOur Advanced Machine Learning organization is building large multimodal foundation models...PrincipalWork at officeImmediate startRemote work
$150k - $300k
...that enable clients to navigate complex, contentious, and often catastrophic situations. Job Description J.S. Held is seeking a Principal Epidemiologist to join our Health Sciences practice. This role is ideally suited for a senior consulting professional who combines...PrincipalRemote workFlexible hours$174k - $252k
...manipulation, data collection for robot learning, sim-to-real transfer, vision-language-action... ...specific types of work. As a Research Scientist, you’ll setup large-scale tests and... ...the breadth of computer science, such as machine (and deep) learning, data mining, natural...- Immunome, Inc. in Bothell, Washington, seeks a Senior / Principal Clinical Scientist in Clinical Development to lead design, execution, and interpretation of oncology trials across programs. You will collaborate with clinical operations, regulatory affairs, and R&D to...Principal
- ...building a high-velocity, data-driven pricing and economic framework to enable access to satellite-based internet services globally. The Principal Economist leads pricing strategies, works with business development, sales, product, and analytics teams, and delivers insights to...Principal
$155.9k - $190.22k
Senior / Principal Scientist, Formulation and Drug Product Development Bothell, Washington, United States Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are...Principal$169.59k - $206.23k
...broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets. Position Overview We are seeking an experienced Principal Scientist, Chemical Development to join our dynamic team to help advance our pipeline of innovative targeted cancer therapies. The...PrincipalAfternoon shift$130k - $160k
...representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. We are seeking a Principal Scientist to provide technical leadership for the development of...PrincipalFull time$119.8k - $234.7k
...and label construction, representation learning, multi-task and proxy objectives, calibration... ...marketplace dynamics. Engineers and scientists on the team work at the intersection of... ...experience building and shipping machine learning models in production. ~ Solid...Ongoing contractWork at officeLocal areaShift work- ...Join to apply for the Principal Data Scientist role at Jobright.ai 3 days ago Be among the first 25 applicants Join to apply for the Principal... ...statistical theory. • Have taken qualifying courses on machine learning concepts including, and not limited to: decision trees...PrincipalFull time
$142.8k - $274.8k
...advertiser strategies and auction mechanisms. In our team, applied scientists work together and utilize all sorts of platforms, techniques... ...but not limited to mathematical modeling and optimization, machine learning, optimal control, game theory, and general economics and...PrincipalOngoing contractWork at officeLocal area$142.8k - $274.8k
...trustworthy, high-scale online experimentation that accelerates product learning and drives progress across Microsoft’s AI ecosystem. You will... ...on the planetCollaborate closely with backend engineers, data scientists, site reliability engineers (SREs), and product managers to...PrincipalOngoing contractLocal area3 days per week$198.9k - $269k
...importance. The FBA organization is looking for a Principal Applied Scientist with deep expertise in Operations Research, Reinforcement Learning, and strong modeling and analytical... ...sequential, non-stationary decisions; machine learning for the prediction and estimation...PrincipalWorldwideFlexible hours$192k - $304.75k
...to accelerated computing. We're looking for a passionate AI research scientist with deep quantum computing expertise to path-find the future of fault-tolerant quantum systems powered by machine learning. Quantum computing is a strategic priority for NVIDIA, and our...Full time$142.8k - $274.8k
...Copilot, Bing, Edge, Windows, and Xbox. We are seeking a Principal Applied Scientist to define and develop the next generation of intelligent... ...industry experience building, evaluating, and deploying machine learning models or AI systems in production.Deep expertise in at...PrincipalOngoing contractWork at officeLocal area$198.9k - $269k
As a Principal Applied Scientist, you are a trusted part of the technical leadership. You bring business... ...are willing to change your mind as you learn more. Your artifacts are exemplary and... ...directions, adopting or inventing new machine learning techniques, conducting...PrincipalFlexible hours$142.8k - $274.8k
...Qualifications Required Qualifications: Bachelor's Degree in Computer Science, Engineering, Artificial Intelligence, Machine Learning, or related technical field AND 6+ years technical engineering experience with coding in languages including, but not limited...PrincipalOngoing contractLocal areaWorldwide$189.4k - $256.2k
...reliable connectivity. The Amazon Leo team is looking for a seasoned Principal Economist who are high performing, motivated and believe in our... ...coverage) 401(k) matching paid time off parental leave Learn more about our benefits at USA, WA, BELLEVUE - 189,400.00 - 25...PrincipalPermanent employmentFlexible hours$102.1k - $202.2k
...division is looking for an experienced Applied Scientist II and a Senior Applied Scientist with a... ...-tuning of LLMs, applying Reinforcement Learning from Human Feedback in the process, and... ...is a plus. Rich experience in machine learning, particularly in NLP and deep learning...Ongoing contractLocal area3 days per week$167.1k - $226.1k
...locations without reliable connectivity.The RoleAs a Senior Applied Scientist in Project Leo, you’ll be leading us in making critical and... ...sensitive decisions that impact customers. You’ll use your machine learning expertise to build solutions that can scale and solve the...Permanent employmentFlexible hours$142k
Microsoft is hiring a Principal Researcher for the Research Sciences team. Location: Redmond, WA, US. Work arrangement: onsite. Your Match How well this role fits your profile. Confirmed H-1B sponsor. The Department of Labor record shows filings under MICROSOFT CORPORATION...PrincipalH1b- .../2024 Details Job Title: Computational Chemistry Research Scientist Type: Contract Location: Building 99, Onsite Workplace: 1... ...to collaborate effectively with cross-disciplinary teams in machine learning, computational materials and chemical sciences, and software...Hourly payContract workImmediate start
- Microsoft in Redmond, WA is seeking a Principal Researcher for the Research Sciences team to advance foundational science and applied research initiatives. This is an onsite, full-time position leading innovative projects across disciplines. Ideal candidates will drive...PrincipalFull time
- Machine Learning Scientist Sesame believes in a future where computers are lifelike - with the ability to see, hear, and collaborate with us in ways that feel natural and human. With this vision, we're designing a new kind of computer, focused on making voice agents part...Full timeContract workFlexible hours
$174.05k - $313.35k
Nintendo is looking for a Sr Principal, Corporate Communications to handle crisis communications and executive messaging. This role requires significant experience in managing high-visibility projects, ensuring messaging aligns with company values. The ideal candidate will...Principal- NVIDIA is seeking a Senior Quantum Error Correction Research Scientist to pioneer fault-tolerant quantum computing for accelerated quantum systems in Redmond, WA. You will lead efforts across quantum information science, error correction, and hardware co-design, collaborating...
$145.82k - $182.02k
...undisclosed solid tumor targets.Position OverviewWe are seeking a highly motivated and experienced Clinical Scientist to join our team. The Senior / Principal Clinical Scientist, Clinical Development will play a critical role in the design, execution, and interpretation...Principal
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Principal Machine Learning Scientist. Be the first to apply!
- applied scientist Redmond, WA
- principal scientist Redmond, WA
- applied sports scientist Redmond, WA
- health scientist Redmond, WA
- drug safety scientist Redmond, WA
- scientist biology Redmond, WA
- safety scientist Redmond, WA
- machine learning research scientist Redmond, WA
- application scientist Redmond, WA
- research scientist - biology Redmond, WA


