Principal Scientist, Protein Engineering

What you will do Use advanced antibody and protein engineering methods to design and optimize novel biotherapeutics Support molecular biology acceleration for complex molecular engineering Work closely with HT protein engineering and computational protein engineers to integrate augmented designs and computational approaches toward accelerated derisking and optimization of biologics for best‑in‑class and first‑in‑class therapeutics Lead and participate in cross‑functional biologics programs from discovery to IND, integrating early research, progression through candidate nomination and selection, with deep experience of drug design and target candidate profiles Foster a high‑performance culture of collaboration, engagement, self‑accountability, and inclusion Qualifications & Experience PhD in Protein Engineering, Biochemistry, Biology, Biophysics, Biotechnology, Bioengineering, Immunology, Pharmaceutical Sciences, Chemistry, Computational Protein Design, or related STEM field with 8+ years of applied experience, or an MS and 10+ years of applied experience, or a B.S. and 14+ years of applied experience Demonstrated deep experience in advancing protein therapeutics from discovery to development, preferably in immune cell engagers Established strong external reputation through high‑impact publications, presentations, and scientific community engagement Excellent verbal and written communication and collaboration abilities Required skills Expertise in functional optimization of biologics, especially immune cell engagers, with demonstrated knowledge in guiding advantageous molecular designs in a competitive landscape In‑depth and current knowledge of antibody and protein therapeutics, with proven skills in molecular biology and antibody and protein optimization/engineering approaches Expert‑level hands‑on experience in protein engineering across wet‑lab and computation‑based methods Strong technical knowledge of multiple aspects of biologics production including protein engineering, expression, purification, and characterization Project leadership experience across discovery stages, from target evaluation, hit identification through preclinical development of therapeutic candidates Prior direct people management, including demonstrated mentorship and a track record of talent development Track record of driving scientific or platform innovations Recognized team player with strong collaboration skills and openness Preferred skills Experience advancing protein therapeutics beyond traditional mAbs, including VHHs, multi‑specifics, fusion proteins, and ADCs Benefits & Compensation Salary range: $176,200.00 – $277,300.00. Eligible for annual bonus and long‑term incentive, if applicable. Comprehensive benefits package including medical, dental, vision, retirement benefits, 401(k), paid holidays, vacation, and compassionate and sick days. Equal Employment Opportunity As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status or other applicable legally protected characteristics. We comply with all affirmative action requirements for protected veterans and individuals with disabilities. #J-18808-Ljbffr Merck & Co. Inc