Principal Software Engineer
GrabJobs
About Chamber: Cardiovascular disease remains the leading cause of death in America. At Chamber, we’re rebuilding the system for cardiology — creating a world where outcomes, not volume, define success. We partner with independent cardiologists to help them lead population health efforts in their communities, equipping them with technology, data, and operational tools that turn complex insights into better care for patients. Our model blends clinical expertise, thoughtful design, and a modern operating platform that supports physicians, patients, and payers alike. We believe innovation and empathy go hand in hand, and by combining cutting-edge AI tools with a relentless focus on human care, we can transform heart health at scale. Role Overview: The Staff / Principal Full Stack Engineer will play a central role in designing and building Chamber’s core application platform. This is a hands-on role for someone who thrives in a startup environment, enjoys solving complex product and data challenges, and is excited to build systems that make a difference in healthcare. This role will help design and build the web applications that power Chamber’s operational tools for care teams and healthcare providers. These applications support real-time cardiology insights and value-based care workflows, combining clinical data, analytics, and AI-assisted features. The role will work across the stack—from modern web interfaces to backend services and API integrations—partnering closely with product, data, and infrastructure engineers to deliver reliable, high-impact software. This role will have a meaningful influence on application architecture, engineering practices, and the evolution of Chamber’s product platform. Areas of Impact Designing and building core systems that power Chamber’s Web apps and operational tools for care teams and providers Contributing to the evolution of our full-stack architecture across the React / Next.js frontend and Node.js backend services Developing application services that integrate with Chamber’s healthcare data platform and FHIR-based systems Building features that combine clinical data, analytics, and AI-powered capabilities Collaborating closely with a small, senior engineering team to shape engineering standards, system design, and product delivery Key Responsibilities Design and build Chamber’s core web applications. Develop and evolve the full-stack systems that power Chamber’s operational tools for care teams and providers. Build scalable application components that support complex healthcare workflows and large volumes of clinical and operational data. Build modern, high-quality web interfaces. Design and implement intuitive user experiences using React, Next.js, and Tailwind. Translate complex workflows and analytics into usable and reliable tools for clinicians and care operations teams. Develop backend services and application logic. Build and maintain Node.js and AWS lambda services that power application workflows, APIs, and integrations. Implement business logic and application services that interact with Chamber’s healthcare data systems, including FHIR-based platforms. Integrate data and AI-powered capabilities. Collaborate with others to integrate analytics and AI-powered features into the application layer. Apply LLM-powered functionality where it meaningfully improves workflows and insights for care teams. Collaborate across engineering disciplines. Work closely with fellow engineers to deliver reliable and scalable systems. Contribute to architectural decisions, engineering standards, and shared development practices. Knowledge, Skills, and Abilities Strong full-stack engineering expertise. Extensive experience building modern web applications, spanning frontend systems, backend services, and API design. Modern frontend development. Strong experience building production applications with React, Next.js, and TypeScript. Able to design maintainable component architectures and deliver high-quality user interfaces. Backend systems and service design. Experience designing and implementing backend services and APIs in Node.js or similar environments. Able to build reliable services that support complex workflows and data interactions. Workflow-oriented product development. Experience building applications that support operational workflows, stateful processes, and real-world user interactions. Collaborative engineering mindset. Able to work effectively within a small, senior engineering team, contributing ideas, shaping architecture, and collaborating closely with product and data partners. Startup ownership mindset. Comfortable operating in fast-moving and sometimes ambiguous environments, taking ownership of meaningful systems and helping drive solutions from concept through production. Job Requirements 8–12 years of experience in software engineering with significant full-stack development experience Proven experience designing and building production web applications Strong experience with React, Next.js, and TypeScript Experience building backend services using Node.js or similar platforms Experience designing APIs and implementing application business logic Experience working with cloud-based systems (AWS preferred) Experience building applications that interact with external APIs or data platforms Strong communication and collaboration skills Comfortable with ambiguity and working in a fast-paced startup environment Must be based in the U.S. and able to align with Eastern Time working hours Nice to Have: Experience working with healthcare data platforms or healthcare technology systems Familiarity with FHIR or healthcare interoperability standards Experience integrating AI-powered functionality into production applications Experience working in HIPAA- or SOC2-compliant environments Location: Remote role based in Eastern Time Zone Chamber Values: Our values guide how we lead, collaborate, and care: Low Ego: We stay grounded, curious, and open to feedback. Empathy: We build trust through compassion and thoughtful communication. Courage: We take action, think critically, and challenge ideas respectfully. Ownership: We follow through with integrity and hold ourselves to high standards. Grit: We push through ambiguity, move with urgency, and solve problems with horsepower and heart.
- ...Principal Software Engineer at DLS Engineering (on-site) DLS Engineering is seeking a Principal Software Engineer for a full-time position supporting a geospatial application in St. Louis, Missouri. This is an on-site position. Why this role is a great next step...SuggestedFull time
$246k - $394k
...engages, supports, and grows customers at scale. As a Senior Principal Engineer for GTM Experiences, you will serve as the LOB-level... ...ll need to thrive (Requirements) 10+ years of experience in software engineering, with a strong background building and evolving...SuggestedLocal areaRemote work- Senior Software Engineer - Vehicle Health ManagementCompany:The Boeing CompanyThe Boeing Company is looking for Senior Software Engineer - Vehicle Health Management to join our Government Vehicle Health Management Systems (GHVMS) software team in Hazelwood, MO. This position...SuggestedFull timeWork experience placementInterim roleRelocationVisa sponsorshipWork visaRelocation packageFlexible hoursShift work
$126.65k - $171.35k
Mission Software Engineer (Experienced or Senior)Company:The Boeing CompanyThe Boeing Company is looking for a MissionSoftware Engineer(Experienced or Senior) to join the Phantom Works Open Architecture Systems Integrated Software (OASIS) Solutions team located in Berkeley...SuggestedPermanent employmentFull timeContract workWork experience placementCurrently hiringRelocationVisa sponsorshipWork visaRelocation packageFlexible hoursShift work$126.65k - $171.35k
Software Developer Engineer (Experienced or Senior)Company:The Boeing CompanyThe Boeing Company is looking for a Software Developer Engineer (Experienced or Senior) to join the Digital Analytics and System Health (DASH) software team in Hazelwood, MO. This role will support...SuggestedPermanent employmentFull timeWork experience placementInterim roleCurrently hiringRelocationVisa sponsorshipWork visaRelocation packageFlexible hoursShift work$126.65k - $171.35k
Software Engineer-Developer, Phantom Works Weapons (Experienced or Senior)Company:The Boeing CompanyThe Boeing Company is seeking an Application Software Engineer (Experienced or Senior) to join the Phantom Works Weapons team in St. Charles, MO (St. Louis Area). This teamsupports...Permanent employmentFull timeWork experience placementCurrently hiringRelocationVisa sponsorshipWork visaRelocation packageFlexible hoursShift work- ...layouts, diagrams, charts, code comments and clear code. Develop software solutions by studying information needs; studying systems flow,... ...recommendations to the program manager and Chief Software Engineer. Coordinate software development activities within product lines...Full timeContract workTemporary work
$150k - $165k
...Senior Software Engineer St. Louis Park, MN Job Summary: We are seeking a Senior Software Engineer with specialized experience in developing software for active implantable medical device systems. This role involves creating robust, secure, and scalable...Full time$184k - $259.44k
...Scale AI is seeking a highly skilled and motivated Software Engineer, ARC (Architecture, Reliability, & Compute) to join our dynamic Public Sector Engineering team. As a part of this team, you will build and maintain internal CLIs/tools that standardize testing, deployment...Full timeWork at office3 days per weekEarly shift- ...C# .NET Software Developer / Software Engineer / Web Application Developer MarketVolt, LLC, a digital marketing software and services firm... ...Software Developer / Software Engineer with a passion for problem solving, please apply today! (Principals only, please)...Full timeShift work
- Lead Software Engineer, Phantom WorksCompany:The Boeing CompanyThe Boeing Company is seeking Lead Software Engineer with an Active Top Secret Security Clearance to support our Phantom WorksOpen Architecture Systems Integrated Software (OASIS) Solutions team in Berkeley,...Permanent employmentFull timeContract workWork experience placementRelocationVisa sponsorshipWork visaRelocation packageFlexible hoursShift work
$126.65k - $171.35k
Application Software Engineer, Phantom Works (Experienced or Senior)Company:The Boeing CompanyThe Boeing Company is looking for an Application Software Engineer (Experience or Senior) to join the Phantom Works Open Architecture Systems Integrated Software (OASIS) Solutions...Permanent employmentFull timeContract workWork experience placementRelocationVisa sponsorshipWork visaRelocation packageFlexible hoursShift work- Lead Software Engineer, Phantom WorksCompany:The Boeing CompanyThe Boeing Company is currently seeking a Lead Software Engineer to support our Phantom Works Software Engineering team located in Berkeley, MO. This position is based in Berkeley, MO; however, it may also be...Permanent employmentFull timeWork experience placementFor subcontractorRelocationVisa sponsorshipWork visaRelocation packageFlexible hoursShift work
$212k - $339k
...services that help people, businesses and governments realize their greatest potential. **Title And Summary** Vice President, Software Engineering – Decision Management Program Join Mastercard’s Services Technology organization as an engineering leader for the...Full timePart timeWorldwideFlexible hours3 days per week- ...Our startup has raised a pre-seed round and is looking to hire engineers for exciting, unique projects. As an early member of the... ...US EST time zone. - At least 3 years of experience as a paid software engineer working at a company where the primary product is software...Hourly payFull timeRemote work
- ...its customer base of elite financial market participants. Job Summary Exegy is seeking a highly motivated senior level software engineer to work closely with other dedicated engineers in our Market Data Engineering group. The engineer will be responsible for the...Full time
- ...Mid-level Software Engineer at DLS Engineering (on-site) DLS Engineering is seeking a Mid-level Software Engineer for a full-time position supporting a geospatial customer in St. Louis, Missouri. This is an on-site position . Why this role is a great next step for...Full time
- ...Syms Strategic Group (SSG) is seeking a talented Software Developer in Test (SDET) Location: Remote Department: Veterans... ...metrics and reporting Occasionally perform other IT systems engineering activities such as requirements, design, installation, operation...Full timeWork experience placementRemote work
- ...have): ~ Research, design, and develop computer and network software or specialized utility programs. ~ Analyze user needs and develop... ..., applying principles and techniques of computer science, engineering, and mathematical analysis. ~ Update software or enhance...Full timeLocal areaImmediate start
$80k - $90k
...into actions that increase loyalty and drive growth for modern banks, lenders, and credit unions. We are seeking an Associate Software Engineer to join our Data Engineering team. In this position you’ll work directly with a team of Data, Software, Infrastructure, and QA...Full timeTemporary workWork at officeWork visaFlexible hours3 days per week- ...or.NET (they have applications in both and will be assigned to the ones that match their skillset) - 2+ years of experience as an engineer with development background - Understanding of relational databases. Unix commands, gather requirements, solve problems. They support...Full time
$169k - $208k
...fusion of former U.S. Special Operations cyber operators, startup engineers, and formerly frustrated cybersecurity practitioners. We're... ...on. Competencies/Requirements Experience building production software, with deep, hands-on experience in browser automation (Playwright...Full timeWork at officeRemote workFlexible hours$166.9k - $230.9k
..., and user session attribution systems that directly influence customer acquisition and loan conversion outcomes. As a Senior Software Engineer at Upstart, you will help scale and extend backend data systems that enable high-quality, reliable marketing data workflows. You...Temporary workSummer workCurrently hiringLocal areaRemote workWork from home$164.2k
...can apply to work remotely in any country in which we have a physical presence. The Data Movement team is looking to hire a Software Engineer who is excited to solve large scale data platform and efficiency challenges. Reddit’s mission is to bring community and...For contractorsWork experience placementWork at officeRemote workFlexible hours$200k - $220k
...TRM to make the world safer and more secure. The Data Platform team collaborates with an experienced group of data scientists, engineers, and product managers to build highly available and scalable data infrastructure for TRM's products and services. As a Data Infrastructure...Remote workWorldwideShift work- ...Freedom Technology Solutions Group is seeking a Software Engineer to support our client’s intelligence analysis products and capabilities. This position involves providing software development capabilities to enhance existing and emerging client capabilities, including...Work at officeFlexible hoursNight shift
- ...to draw crucial insights through data, feeds, analytics, AI and workflow solutions. The Opportunity We are seeking passionate software engineers from mid-level to lead to help us build robust, enterprise-grade solutions that drive real-world impact. Our problems are...
$190k - $250k
...venture capital investments accessible to anyone. Through the software we build, we are democratizing the private investment industry.... ...person collaboration when needed. We're seeking a Lead Software Engineer to manage a team within our API Engineering group. This team owns...Temporary workLive inRemote workFlexible hours$85k - $115k
...Advanced Software Engineer ProSight Financial Association, a leading industry organization, is seeking an experienced and results-driven Advanced Software Engineer with strong .NET/C# and SQL skills and hands-on experience developing Microsoft Azure cloud solutions....Work at officeRemote workFlexible hours- ...serve . We’re growing rapidly and looking for exceptional people to join us. About the Role We are looking for a Senior Software Engineer to join our Online Data Stores team, a critical part of the Infrastructure team at Persona. You'll play a key role in building...Full timeFor contractorsInternshipRemote work
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Principal Software Engineer. Be the first to apply!
- principal Saint Louis, MO
- senior principal cloud computing engineer Saint Louis, MO
- senior principal scientist Saint Louis, MO
- software engineer - cloud services Saint Louis, MO
- id software Saint Louis, MO
- healthcare software sales Saint Louis, MO
- software technical support Saint Louis, MO
- software asset management analyst Saint Louis, MO
- software implementation project manager Saint Louis, MO
- software sales executive Saint Louis, MO



