Director of Scale-up Operations and Engineering
Phykion
Job Description
About Phykion
\nPhykion is reimagining aviation fuel. We cultivate hyper-productive microalgae to produce a scalable, low-carbon oil that drops directly into the HEFA pathway — the most commercially established route to sustainable aviation fuel. Our platform is built on three breakthroughs: a field-proven algae host with 5+ years of outdoor cultivation, strain engineering trait stacking that has delivered a 10x gain in oil productivity to date, and an outdoor cultivation process on non-arable land fed by seawater and CO2. We are scaling this validated technology into demonstration production, paving the way for commercial supply of low-carbon oil by the end of the decade. As part of that scale-up, we are re-opening our pilot facility near Calipatria, California, and building the team that will bring the site back online and run it.
\n \nThe Role
\nWe are seeking an experienced process engineer to lead the technical re-establishment of the facility and own our downstream process — the dewatering, lysis, and extraction operations that turn cultivated algae biomass into product. Working closely with the Algae Production Lead and the Facilities Supervisor, the Director will stand up equipment, define operating procedures, troubleshoot at scale, and set the technical direction for harvest and downstream processing as the facility ramps. The performance and economics established here will underwrite our path to commercial demonstration.
\n \nDuties and Responsibilities
\n- \n
- Provide general facility oversight and technical direction in close partnership with the Algae Production Lead and the Facilities Supervisor. \n
- Own the design, commissioning, operation, and continuous improvement of the downstream process train (dewatering, lysis, extraction, recovery). \n
- Lead the facility re-start, including pre-commissioning checks, mechanical and process verification, and performance testing. \n
- Translate laboratory and bench-scale recovery processes into pilot-scale operations with an eye toward commercial demonstration; partner with R&D on scale-up experiments and interpretation. \n
- Develop mass and energy balances and process flow diagrams; steward SOPs, batch records, and process control approaches for downstream operations. \n
- Manage technical scope with external vendors and engineering partners for new installations and modifications. \n
- Identify opportunities to reduce production cost and energy intensity and to improve process reliability; lead the resulting capital and operational projects. \n
- Champion a strong safety culture; with support from EH&S, ensure compliance with applicable safety, environmental, and regulatory requirements. \n
- Help build the pilot team through hiring, training, and development of production and engineering staff. \n
Requirements and Experience
\n- \n
- B.S. in Process, Chemical, Mechanical, Agricultural, or related Engineering discipline required; M.S. or Ph.D. preferred. Equivalent education and experience considered. \n
- 10+ years of relevant industry experience in process engineering, with technical leadership in downstream bioprocessing, algae or fermentation-based production, food/feed processing, or comparable bio-based manufacturing. \n
- Deep, hands-on experience with downstream unit operations — dewatering, centrifugation, filtration, drying, separations, extraction, and product clean-up — at pilot or commercial scale. \n
- Demonstrated experience commissioning and starting up process equipment and downstream production lines, ideally including facility re-start, scale-up, or new-facility build-out. \n
- Direct experience with algae cultivation and harvest (open ponds, raceways, or photobioreactors) is a plus. \n
- Excellent written and verbal communication; able to translate complex technical concepts for non-engineering audiences and communicate clearly with site staff and leadership. \n
- Authorization to work in the United States is required. \n
Work Location and Schedule
\nOn-site at our pilot facility near Calipatria, CA. Standard schedule with flexibility to support a 24/7 operation, including occasional weekend, evening, and on-call coverage during commissioning and campaign runs.
\n \nRelocation
\nRelocation assistance available for qualified candidates relocating to the Calipatria area. The Imperial Valley and surrounding communities offer a range of housing options at attractive cost of living relative to coastal California.
- ...Qualcomm Technologies, Inc. seeks a Senior Director of Engineering in San Diego to lead rack-scale platform strategy and thermal designs for data center systems. You will partner with ODMs, customers, and internal teams to drive multi-generation roadmaps and enable scalable...Suggested
- ...ecosystem. You will lead end-to-end product strategy, work closely with engineers and architects, and translate user insights into high-impact features. This role offers opportunities to influence at scale and collaborate across product, design, and data #J-18808-Ljbffr...Suggested
$199.4k - $299.2k
...entertainment excellence and creativity.As a member of the Production Operations Engineering team within the platform technology group, you will help... ...plans and operational acceptance criteria.Architect and scale tools, scripts and automation frameworks across API/service...SuggestedShift work- ...Technical Program Manager 4 in San Diego to drive critical development programs from inception to delivery. You will collaborate with engineering, finance, and leadership to maintain schedules, costs, and milestones in a fast-paced startup environment. This role requires...Suggested
- ...SUMMARY The Preconstruction Director serves as a key member of each... ...as the team liaison between operations, estimating and design management... ...with architects and engineers Builds and maintains solid... ...managing preconstruction for large scale projects with emphasis on...SuggestedFull timeContract workFor subcontractor
$110k - $125k
...The Director builds and leads Joan and Irwin Jacobs JFS Connect, a mobile community health... ...JFS Connect and owns its launch, daily operations, partnerships, budget and results. This... ...programs. ~ A record of launching or scaling a new program, ideally one delivered in...Full time- ...support M&A activities. The Director of Talent Acquisition leads... ...position, and driving operational excellence across all hiring... ...strategic recruiting programs at scale. Strong executive... ...capabilities include custom design and engineering; rapid prototyping; sensor...Full timeTemporary workFor contractorsWork at officeLocal areaRemote work
$205.1k - $307.7k
...more than you ever thought possible.The Director, Bioinformatics will provide strategic leadership... ...a team of bioinformatics scientists and engineers, this leader will define and execute... ...technologiesExperience with cloud-scale informatics platforms, AI/ML technologies...Full timeLocal area$215k - $260k
...Protego Biopharma is seeking a Director, Drug Substance Development... ...scientific, technical, and operational leadership for active... ...development, process optimization, scale up, technology transfer, GMP... ...transfer, scale up, engineering and registration campaigns,...Full timeWork at officeRelocation packageMonday to Friday$195k - $244k
...turns strategy into delivery.As Director, Portfolio Management (... ...across Diagnostics, strengthening operating models, governance and ways... ...teams can deliver effectively at scale.What You'll DoOwn end-to-end... ....Partner with Product and Engineering leaders to influence roadmap...Local areaFlexible hours- ...therapy.Artiva is seeking a Director, MSAT, CMC & Process Validation... ...CMC, and GMP manufacturing operations.Duties/Responsibilities• Own... ...as the organization scales toward commercial readiness.... ...in biotechnology, chemical engineering, or related discipline.• Minimum...Flexible hours
- Job Description:We are seeking a Director, CMC-Drug Substance to join our growing organization... ..., and deliverables are metDrive process scale-up, process characterization, and... ...Qualifications:Masters Degree and/or PhD in Chemical Engineering, Biochemistry, Biotechnology, or related...Full timeContract workTemporary workLocal areaMonday to FridayFlexible hoursShift work
- ...SUMMARY The Preconstruction Director serves as a key member of each... ...as the team liaison between operations, estimating and design management... ...with architects and engineers Builds and maintains solid... ...managing preconstruction for large scale projects with emphasis on...Full timeContract workFor subcontractor
$130k - $160k
...Job Description Associate Director, Paid Media & Performance Creative... ...build a paid acquisition engine that is as distinctive and... ...Identify winners quickly, scale what works, and document learnings... ...creating systems, not simply operating someone else’s playbook. \n...Fixed term contract$176.7k - $233.2k
...impact on the planet. ecoATM is hiring a Director, Tax reporting to our Chief Accounting Officer... ...and filing positions; providers deliver scale and specialty depth, not judgment.... ...documentation required to run them internally. Operate initially as a working individual...Permanent employmentTemporary workFor contractorsLocal areaRemote work$210k - $265k
...amyloidosis (ATTR). About the job The Director, Medical Writing is responsible for... ..., templates, style guides, and standard operating procedures through innovation and... ...medical writers and CRO/vendor partners to scale writing capacity during peak deliverable...Full timeWork at officeRemote workRelocation packageMonday to Friday- ...team of over 50,000 planners, designers, engineers, scientists, digital innovators, program... ...requirements, design standards and operational considerations.This position requires strong... ...in your local community and on a global scale - that are transforming our industry and...For contractorsWork at officeLocal areaWorldwideFlexible hours
$189 per hour
...rare patients.Position Summary:The Director, Technical Operations (Biologics CMC Technical Writing) is... ...in pharmaceutical sciences, chemical engineering, biotechnology, or a related discipline... ...control, process validation, scale up, comparability, stability, and commercial...Contract workWork experience placementWork at officeLocal areaRemote work2 days per week$150k - $195k
...fundamental problem: the systems needed most by operators are often too expensive, too slow to produce, and too difficult to sustain at scale. Firestorm exists to change that. We... ...hiring a Senior Software Test Automation Engineer to build the tests, tools, and...Permanent employmentTemporary workLocal areaRelocationRelocation package- ...Qualcomm's QStudio seeks a Director of Studio Management & Creative Operations to lead resourcing, budgets, and workflow for the in-house agency. You'll partner... ...Expression, Campaign Creative, and Xperience to scale operations while maintaining quality. The role emphasizes...Full time
- ...portfolio turns strategy into delivery. As Director, Portfolio Management (Diagnostics), you... ...delivery works across Diagnostics, strengthening operating models, governance and ways of working so teams can deliver effectively at scale. What You'll Do Own end-to-end...
$195k - $215k
...alternative application process. Senior Director, Growth Full Time San Diego, CA,... ...Director of Growth to build and scale OmniWatch’s growth engine across acquisition, conversion,... ...roadmap, the economics behind it, and the operating cadence required to move it forward....Full timeWork at officeLocal area$170.6k - $256k
## Director PCB CADSan Diego, California, United States of AmericaApply... ..., Inc.## **Job Area:**Engineering Services Group, Engineering Services... ....* 4+ years of working with operating budgets and/or project... ...0 - $256,000.00The above pay scale reflects the broad, minimum to...Work experience placementWork from homeOverseas$193.5k - $338.8k
...for patients, we invite you to join us. Director, AI/ML - Generative Foundation Models for... .... By bringing together AI/ML, protein engineering, automation, structural biology, and high... ...scientific leader who wants to build and scale technologies that directly shape...Full timeFlexible hours$191.67k - $233.84k
...The Port of San Diego is hiring a Director of Maritime to lead its Maritime line of business... .... The Director will oversee commercial, operational, and administrative functions related to... ...a management background in large-scale industrial maritime facilities or transportation...Contract workTemporary workFor contractorsLocal areaRemote work- ...Independent Director (Board-level role) About the Company Privately... ...manufacturing, industrial, engineering-focused, food service... ...in driving strategic growth, operational excellence, and product innovation... ..., and organizational scaling, and experience with founder...
- ...responsible for managing day-to-day HR operations while ensuring compliance with employment... ...independently and build structure as the company scales. Key Responsibilities HR... ...may evolve into a Senior HR Manager or HR Director position as the company grows....Full timeFor contractorsWork at officeLocal area
- ...across the portfolio.The Technical Director will serve as the senior technical... ...Leadership, Strategy, Design, Engineering, Program Management, and Operations to translate ambitious client goals... ...stronger and more consistent as we scale.At its core, the role exists to raise...
$195k - $244k
...about the Role In your role as Director, Portfolio Management (... ...and Provider domains. You will operate across geographically distributed... ...predictable outcomes at scale. You will also design and continuously... ...Partner with Product and Engineering leaders to influence roadmap...Temporary workWork experience placementFlexible hours$155k - $170k
...helping The Center grow, strengthen its operations, and advance its mission. POSITION SUMMARY... ...: partnering with the CEO and Board of Directors to vision; planning for The Center's... ...benefits package, inclusive of Competitive Pay Scales, 401(k) Retirement Plan (with company...Full timeContract workTemporary workPart timeFor contractorsWork at officeImmediate start
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Director of Scale-up Operations and Engineering. Be the first to apply!
- special operations manager San Diego, CA
- sr operations manager San Diego, CA
- business operations director San Diego, CA
- enterprise operations manager San Diego, CA
- senior manager warehouse operations San Diego, CA
- hvac operations manager San Diego, CA
- computer operations manager San Diego, CA
- senior director clinical operations San Diego, CA
- operations manager supervisor San Diego, CA
- director of corporate operations San Diego, CA






