Scientist - Rare Disease Biology

Career Category Scientific Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist - Rare Disease Biology What you will do Let’s do this. Let’s change the world. In this vital role you will contribute to the discovery and advancement of innovative therapies for rare diseases as a core member of multidisciplinary, disease-focused research teams. You will apply experimental and data-driven approaches to investigate disease mechanisms, evaluate novel therapeutic targets, and generate insights that inform scientific and portfolio decisions. This role offers the opportunity to work at the intersection of autoimmune disease biology, fibro-inflammatory mechanisms, tissue remodeling, human disease data, and emerging technologies within a highly collaborative and scientifically rigorous environment. Key Responsibilities Design, execute, analyze, and interpret in vitro and ex vivo studies to investigate disease mechanisms and evaluate therapeutic hypotheses. Generate high-quality, reproducible experimental data to support target identification, validation, and progression of rare disease research programs. Investigate biological mechanisms relevant to Thyroid Eye Disease (TED), including immune dysregulation, fibroblast activation, inflammatory signaling, extracellular matrix regulation, and tissue remodeling. Integrate experimental findings with scientific literature, human genetics, clinical observations, and multi-omic datasets to develop mechanistic insights and inform scientific decision-making. Develop and implement innovative experimental approaches that enhance scientific rigor, efficiency, and translational relevance. Collaborate closely with disease biologists, computational scientists, translational researchers, and other partner functions within multidisciplinary research teams. Contribute data-driven insights and recommendations to scientific discussions, target reviews, program strategy, and portfolio evaluations. Build productive relationships with internal and external collaborators, including academic investigators, foundations, CROs, and scientific experts, as appropriate. Communicate scientific findings, interpretations, and recommendations effectively to project teams, governance forums, and departmental audiences. Maintain accurate experimental documentation and contribute to organizational knowledge sharing. Foster a culture of scientific curiosity, collaboration, continuous learning, and operational excellence. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The Scientist we seek is a researcher with these qualifications. Basic Qualifications Doctorate degree OR Master’s degree and 2 years of relevant scientific research experience OR Bachelor’s degree and 4 years of relevant scientific research experience Preferred Qualifications Expertise in one or more areas relevant to fibroblast biology, stromal cell biology, tissue remodeling, fibrosis, extracellular matrix biology, inflammation, or fibro‑inflammatory disease. Experience investigating cellular and molecular mechanisms that drive tissue inflammation, remodeling, and pathological structural changes. Demonstrated expertise in designing and executing cell‑based, molecular, and biochemical assays to interrogate complex disease biology and therapeutic hypotheses. Hands‑on experience with primary human cells, fibroblast systems, tissue‑derived cultures, organoids, or other advanced in vitro/ex vivo disease models. Strong understanding of biological pathways involved in fibroblast activation, extracellular matrix regulation, fibrosis, wound healing, inflammation, and tissue remodeling. Experience applying multi‑omics data or other data‑rich approaches to characterize cellular phenotypes and disease mechanisms. Strong quantitative and data‑analysis skills, with demonstrated ability to interpret complex biological datasets and translate findings into testable hypotheses. Experience integrating experimental data with human genetics, omics, clinical data, and scientific literature to generate mechanistic and translational insights. Ability to combine experimental and computational approaches to solve complex biological questions and support target evaluation. Scientific curiosity and demonstrated ability to rapidly learn new disease areas, biological systems, technologies, and analytical approaches. Ability to work effectively in collaborative, multidisciplinary, and matrixed research environments. Excellent written and verbal communication skills, with the ability to communicate complex scientific concepts clearly to diverse audiences. Ability to balance scientific rigor, urgency, and adaptability in a dynamic research environment. Demonstrated commitment to teamwork, knowledge sharing, and continuous improvement. Familiarity with AI‑enabled scientific tools, computational workflows, image analysis, automation, or advanced data analytics is desirable. What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan Stock‑based long‑term incentives Award‑winning time‑off plans Flexible work models where possible. Application Deadline Amgen anticipates accepting applications until September 16th, 2026; however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates. Redaction Policy In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Sponsorship Sponsorship for this role is not guaranteed. Equal Opportunity Statement As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance. Work Location Type Refer to the Work Location Type in the job posting to see if this applies. Salary Range 123,052.80USD -166,483.20 USD About Amgen Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit and follow us on #J-18808-Ljbffr Amgen Inc. (IR)