Leader of Structure Biology and Protein Chemistry
$237.3k - $355.9kMerck
Work Your Magic with us! Start your next chapter and join EMD Serono.Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us. United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.Your RoleAt the intersection of structural science and therapeutic innovation, this role offers a rare opportunity to define how structure-guided insights translate into life-changing medicines. As Director, Structural Biology & Protein Chemistry, you will lead a team of more than ten scientists, setting the strategic direction for structural biology and protein chemistry across a broad and ambitious drug discovery portfolio. You will drive programs from target validation through to early clinical candidates, integrating structural, functional, and mechanistic data to inform medicinal chemistry, antibody engineering, and therapeutic modality decisions. Operating with significant autonomy, you will partner closely with biology, pharmacology, and DMPK functions, manage external collaborations and CRO partnerships, and contribute to IP strategy by translating structural findings into patentable discoveries. You will also champion scientific excellence and mentor the next generation of structural biology talent.Who You AreBasic/Minimum Qualifications:PhD in Structural Biology, Biochemistry, Biophysics, or a closely related field, with at least 10 years of relevant experience in the pharmaceutical or biotechnology sector.Minimum 5 years of direct leadership or managerial experience of multiple reports, with a demonstrated ability to build, develop, and retain high-performing scientific teams. Proven track record of delivering drug discovery programs from target validation through to clinical candidates, including Pre-IND or IND-enabling experience.Hands-on expertise in the expression, purification, stabilization, and biophysical characterization of challenging protein targets, including membrane and soluble proteins.Proficiency in Cryo-EM is essential. Capabilities in at least one other structure determination technology, such as X-ray crystallography or nuclear magnetic resonance (NMR), with experience in hybrid or integrative structural approaches.Record of high-impact publications demonstrating structural and mechanistic insights relevant to drug discovery.Preferred Qualifications:Experience with emerging therapeutic modalities, including antibody-drug conjugates (ADCs), bispecific antibodies, PROTACs, or covalent inhibitors.Established external network with academic institutions or industry partners to accelerate drug discovery programs.Experience contributing to patent filings and intellectual property strategy based on structural biology findings.Familiarity with modern data management, bioinformatics, and collaboration tools used in structural biology and drug discovery.Strong verbal and written communication skills, with the ability to present complex structural data clearly to senior leadership and non-specialist stakeholders.Pay TransparencyPay Range for this position: $237,300.00 - $355,900.00The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here. US Equal Employment OpportunitiesThe Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law. This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!
$117k - $158.2k
...Scientist, Biocatalysis & Protein Engineering will... ...libraries using molecular biology, recombinant protein... ...Biochemical Engineering, Chemistry, or a related... ...knowledge of enzyme kinetics, structure-function relationships... ...AlnylamWe are the leader in RNAi therapeutics -...StructuresFull timeTemporary workLocal areaFlexible hours- ...network of companies is the global leader in food, environment,... ..., traceability and purity of biological substances and products.... ...antibodies, antibody drug conjugates, proteins, mRNA and vaccines.... ...least a BS in Pharmaceutics, Chemistry, Chemical/Biochemical Engineering...SuggestedFull timeContract workH1bMonday to Friday
$108.5k - $201.5k
Job Description SummaryThe Biologics Research Center (BRC) at Novartis BioMedical... ...a motivated and highly experienced leader in field of Physical Chemistry Analytics (PCA) and Mass... ...pipeline (e.g. antibodies, fusion proteins, ADCs, bi- and trispecifics, AAVs,...SuggestedFull time$135k - $150k
...seeking a Senior Scientist to drive key protein engineering workstreams within campaigns... ...scientists, and experimental teams to apply structure-guided and AI-enabled design approaches,... ...artificial intelligence, computational biology, and structural biology to help improve...Structures- The Biological and Chemical Technologies Group addresses critical national... ...of advanced biology and chemistry approaches. Our multi-... ...for detecting chemicals and proteins, design of enzymes used for... ...computational tools in areas such as structure prediction/generation,...StructuresWork experience placement
$177.4k - $266.2k
...a scientific and technical leader to advance machine learning... ...discovery scientists understand biological and chemical patterns,... ...the realities of medicinal chemistry, structural biology, and drug discovery... ...ADMET and developability, protein structure and ligand binding...StructuresLocal area$130.8k - $209.4k
...technical role for an experienced protein designer who can build and... ...therapeutics: as stand-alone biologics, targeting modules, or... ...clinic and establish Moderna as a leader in antibody and de novo binder... ...for experimental testing.Use structure prediction, generative design...StructuresPermanent employmentFull timeWork from home$107.5k - $204.5k
...future of aerospace and defense. Raytheon is seeking a Section Leader in the Naval Systems Department within the System Integration and... ...candidate resides in a U.S. territory, the appropriate pay structure and benefits will apply.RTX anticipates the application window...StructuresTemporary workWork experience placementWork at officeRemote workRelocation packageFlexible hoursShift work$107.5k - $204.5k
...integration, and system interconnects.We are currently seeking a Section Leader - Manager, Mech. EngRole is an On-Site role in Tewksbury, MA/... ...candidate resides in a U.S. territory, the appropriate pay structure and benefits will apply.RTX anticipates the application window...StructuresTemporary workWork experience placementWork at officeRemote workRelocationFlexible hours$132.4k - $251.6k
...employment opportunity for a Senior Principal Actuation Systems Leader (P5 Electrical Engineer) with control system, power conversion,... ...candidate resides in a U.S. territory, the appropriate pay structure and benefits will apply.RTX anticipates the application window...StructuresPermanent employmentTemporary workWork experience placementWork at officeRemote workRelocationFlexible hours$146k - $236.5k
...You will work at the interface of structure-based modeling and generative ML... ...: Work directly with medicinal chemistry, pharmacology, and external structural biology and assay partners; turn... ...target classes such as: GPCRs, protein-protein interactions, transcription...Structures$180k - $258.5k
...pioneering the emerging field of Protein Editing. At Expedition... ...molecules that edit protein structure and function to unlock presently... ...novel small molecule chemistry and chemoproteomic discovery... ...evaluated on high-quality, biologically and chemically meaningful dataDevelop...Structures- ...solutions. Mentor and develop associates and scientists in analytical development. We are looking for: Bachelor’s degree in biology, Chemistry or equivalent; advanced degree preferred 10+ years of related experience post-degree Proven ability to lead cross-...Contract work
$45 - $55 per hour
...is comfortable operating in a startup environment, creating structure where processes are still being developed, and taking ownership... ...degree in Medical Technology, Clinical Laboratory Science, Biology, Chemistry, or a related scientific field. Prior experience working...StructuresPermanent employmentFull timeLocal areaRelocation packageFlexible hours$114.1k - $211.9k
...planning. The Biomarker Strategy Lead will partner closely with Biology, In Vitro, In Vivo, Data Science and Biomarker Development to... ...211,900.00Skills DesiredAnalytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Curious Mindset, Data Analysis...Full timeLocal areaFlexible hours$142.5k - $256.5k
...Scientist to support computational protein design across therapeutic... ...deep expertise in protein structure, de novo binder design, molecular... ...a scientific and technical leader for computational binder... ...partnership with structural biology, directed evolution, immunology...StructuresPermanent employmentFull timeWork at officeWork from home- ...cross-functional project teams spanning biology, DMPK, biomarkers, translational medicine... ...team capability through coaching and structured development planning, and represents the... ...animal research practices.Experience with protein-based and molecular biomarker assays (ELISA...StructuresFlexible hours
$108.5k - $201.5k
...Principal Scientist I or II, Oligonucleotide Chemistry and Innovation, you will play a critical... ...oligonucleotide chemistries through structure-activity relationship studies.Develop... ...Chemistry, Chemical Analysis, Chemical Biology, Chemical Laboratory, Chemical Synthesis...StructuresFull timeLocal areaWorldwideFlexible hours$118k - $157k
...and maintain pricing models, including list prices, discount structures, and pricing strategies in coordination with the product management... ...is truly a collaborative effort as we realize there are leaders at every level of the organization. We put our values at the core...StructuresFull timeH1bWork at office- ...improve interoperability, analytics, search, engineering efficiency, and AI capabilities.Partner with the applied AI team to provide structured domain knowledge, grounding, and contextual relationships.Develop reference implementations and working prototypes that...StructuresFlexible hours
$107.5k - $204.5k
...integration, verification, validation and sustainment.As a Section Leader, you will be expected to actively participate in department... ...successful candidate resides in a U.S. territory, the appropriate pay structure and benefits will apply.RTX anticipates the application window...StructuresTemporary workWork experience placementWork at officeRemote workFlexible hours$107.5k - $204.5k
...Failure Reporting and Corrective Action System (FRACAS) Section Leader to work onsite in Woburn, MA. As a Section Leader, the... ...successful candidate resides in a U.S. territory, the appropriate pay structure and benefits will apply.RTX anticipates the application window...StructuresContract workTemporary workWork experience placementWork at officeRemote workRelocation packageFlexible hours$86.8k - $165.2k
...selected candidate will have exposure to various functional senior leaders and will work closely with the Program Manager, Integrated... ...successful candidate resides in a U.S. territory, the appropriate pay structure and benefits will apply.RTX anticipates the application window...StructuresContract workTemporary workWork experience placementWork at officeImmediate startRemote workFlexible hours$88k - $132k
...harnessing AI to decode untapped diverse chemistry to develop breakthrough oral medicines... ...nature’s bioactive chemistry and human biology - supercharging the drug discovery process... ...knowledge of small molecule chemistry, structure, and nomenclature.Exceptional attention...StructuresWork at office$100k - $186.3k
...candidate will have deep expertise in cancer biology, organoid/PDX technologies, novel... ...communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer... ...The hiring range is based on market pay structures, with individual salaries determined by...StructuresFull time$215k - $300k
The Mechanical Engineering Group is seeking an Assistant Group Leader to lead the functional team and oversee the development of mechanical... ..., opto-mechanical systems, novel mechanisms, high-performance structures, custom electronics packaging, and detailed mechanical design....StructuresWork experience placementFor subcontractorWork at office$119.7k - $222.3k
...deliverables across the organization. Our unique organizational structure enables colleagues to work seamlessly in the... ...scope of the role potentially includes small molecules, biologics/therapeutic proteins, antibody drug-conjugates, radioligand therapies and/or cell...StructuresFull time$107.5k - $204.5k
...performance.\n \n This role is a U.S.-based role. If the successful candidate resides in a U.S. territory, the appropriate pay structure and benefits will apply.\n \n RTX anticipates the application window closing approximately 40 days from the date the notice...StructuresTemporary workWork experience placementWork at officeLocal areaRemote workFlexible hours$115k - $140k
...nucleoside analogs, phosphoramidites, backbone chemistries, and oligonucleotide architectures to... ...tissue delivery.Generate and interpret structure-activity relationships (SAR) to guide... ...in collaboration with bioinformatics and biology teams to support cellular and in vivo...StructuresRemote job$132.4k - $251.6k
...Engineering Deputy Cross Product Team Lead (CPTL) and Section Leader responsible for the management of 12-16 engineers. This opportunity... ...candidate resides in a U.S. territory, the appropriate pay structure and benefits will apply.RTX anticipates the application window...StructuresFull timeTemporary workWork experience placementWork at officeRemote workFlexible hours
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