Associate Scientist II, Protein Science

Soufflé Therapeutics is a biotech company focusing on the cell-type specific delivery of genetic medicines. It's team of driven scientists is making a mark in delivery of oligonucleotides to extrahepatic tissues. We thrive in a purpose-building lab and office space in Watertown. Come and join us in our quest! Position Summary: Soufflé Therapeutics is expanding its Ligand Optimization team within Protein Science to meet growing pre-clinical pipeline demand and to evolve our ligand engineering platform with next-generation sequencing (NGS) and generative AI/ML biologics design. As an Associate Scientist II, you will run hands-on ligand optimization work while helping build the data-driven workflows that shape how we discover and engineer our cell-type specific therapeutics. This is a new role with direct impact on advancing our pre-clinical programs. Key Responsibilities Support ligand optimization efforts to meet the needs of our pre-clinical programs Perform next-generation sequencing (NGS) workflows to bolster ligand library screening activities Partner with the data science team to design and generate ligand libraries using deep sequencing data and AI/ML generative models Perform ligand library screening using yeast or phage display methodologies Partner with the protein production and ligand screening teams to produce reagents and evaluate ligands that enable biologics discovery activities What Success Looks Like In 3 months: Become familiar with our established ligand optimization workflows In 6 months: Independently perform ligand optimization experiments and NGS library preparation and sequencing In 12 months: Contribute to ligand library design using AI/ML computational models and execute optimization campaigns to completion Qualifications — Required 1 to 2 years of relevant experience in a similar role with an MS, or 2 to 3 years with a BS Experience with next-generation sequencing (NGS), flow cytometry, and cell culture Qualifications — Preferred Experience with antibody engineering methodologies Experience with yeast and/or phage display Familiarity with computational protein design tools Self-starter who collaborates well and communicates clearly Education BS or MS in a relevant scientific discipline At Soufflé Therapeutics, we are intentional about building an equitable culture. How we treat our people is reflective of this focus. We share the pay range for this specific role with the actual base salary reflected in criteria such as job-related knowledge, skills, market factors, and experience: This is an onsite position in Watertown, MA (US) with flexibility as needed for collaboration and external engagements. We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. #J-18808-Ljbffr Soufflé Therapeutics