Senior Software Engineer, Agentic Systems (Manhattan)

Asepha is based in New York and Toronto, building agentic solutions that re-imagine how medications are prescribed, verified, and supported across the pharmacy ecosystem. Backed by venture capital funding and trusted by multiple Fortune 50 healthcare organizations, we’re scaling rapidly and seeking a talented, innovative Senior Software Engineer to join our growing team. As one of our early hires, you’ll play a critical role in shaping our engineering efforts, making key architectural decisions and writing code to expand our AI product line. You will play a pivotal role in balancing speed of execution with product quality, and have the opportunity to wear multiple hats, from frontend and backend development to devops and customer interactions. Your work will have a direct impact on improving pharmacy workflows and health outcomes. Learn more at

Join our mission:

We’re building a world where medication delays are impossible. From the moment a prescription is written, the path to therapy start is clear, fast, and predictable. Asepha is the context graph for the therapy-start journey, connecting the fragmented steps that slow down medication access: intake, coordination, utilization management, and clinical services.

Role and Responsibilities:

• Design and build autonomous agents that handle complex, multi-step pharmaceutical workflows end-to-end
• Architect communication systems that coordinate across organizational boundaries
• Build robust orchestration layers for long-running tasks with graceful failure handling and human-in-the-loop escalation
• Develop frameworks that let agents interact with external pharmacy systems, databases, and APIs
• Implement evaluation and observability infrastructure to monitor agent behavior in production
• Integrate with healthcare data standards and legacy pharmacy systems
• Scale systems to handle real-time processing across multiple pharmacy networks

Qualifications:

• 5+ years of experience in software engineering with strong backend focus
• Proficiency in Python or TypeScript and deep knowledge of backend fundamentals: APIs, data stores, concurrency, distributed systems
• Experience with web frameworks and service-oriented architectures (FastAPI, Flask, or equivalent) and designing clean, versioned APIs
• Familiarity with caching, messaging, and database technologies (Redis, Kafka, SQL/NoSQL, vector databases) and how to use them for performance and reliability
• Experience building for cloud infrastructure (Azure, AWS, or GCP)
• Experience building and deploying agentic AI systems. You understand tool use, planning, memory, and orchestration patterns
• You've built systems where the hardest part wasn't the code, it was figuring out what to build
• You've shipped something end-to-end with minimal guidance and owned the outcome
• Located in Manhattan and can commute to our downtown office 3 days per week

Perks :

• Competitive compensation package, including $130-200k annual salary + stock options
• Full medical, dental, vision, and extended health
• Unlimited days off to maintain a healthy work-life balance + 2 weeks of company-wide office closure during the holidays
• 2 annual off-site trips with the team
• Complimentary breakfast and lunch provided daily in the office. Dinner also provided if staying past 7pm

Note: Only candidates selected for an interview will be contacted.

Asepha is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity or expression, religion, national origin or ancestry, age, disability, marital status, pregnancy, protected veteran status, protected genetic information, political affiliation, or any other characteristics protected by local laws, regulations, or ordinances.