Principal Investigator / LCMS Scientist
RPM ReSearch
Job Description
Job Description
Principal Research Scientist – LC-MS/MS Bioanalysis
Everett, Washington | Relocation Assistance Available
RPM ReSearch has partnered with a leading preclinical Contract Research Organization (CRO) to identify a Principal Research Scientist – LC-MS/MS to join its growing bioanalytical sciences team. Our client partners with pharmaceutical and biotechnology companies to support the discovery and development of novel therapeutics through high-quality GLP bioanalytical services. This is an opportunity to join a collaborative scientific organization where your expertise will directly contribute to advancing new therapies toward the clinic.
Important Qualification
Experience supporting Antibody-Drug Conjugate (ADC) bioanalysis is required for this position.
While we welcome applicants with strong LC-MS/MS backgrounds, this particular opportunity requires prior experience developing, validating, and/or supporting LC-MS/MS methods for ADCs within a GLP pharmaceutical or CRO environment. Candidates without ADC experience are unlikely to be a match for this role.
About the Role
As the Principal Research Scientist, you will serve as the technical and scientific expert for LC-MS/MS bioanalysis, with particular emphasis on ADCs and large molecule assays. You'll provide scientific leadership across method development, validation, sample analysis, study execution, and client interactions while collaborating closely with cross-functional scientific and regulatory teams in a GLP environment.
Key Responsibilities
- Provide scientific leadership for LC-MS/MS bioanalysis supporting both small and large molecule programs, including ADCs.
- Lead method development, validation, troubleshooting, and sample analysis for GLP bioanalytical studies.
- Serve as Principal Investigator or lead scientist on client-sponsored studies.
- Partner directly with pharmaceutical and biotechnology clients, providing technical expertise and scientific consultation.
- Prepare and review scientific reports, study documentation, and laboratory records.
- Ensure compliance with GLP regulations, FDA guidance, SOPs, and quality standards.
- Collaborate with Quality, Regulatory, and laboratory teams to support successful study execution and continuous process improvement.
Qualifications
The successful candidate will have:
- Bachelor's, Master's, or Ph.D. in Chemistry, Biology, Immunology, or another relevant scientific discipline.
- Significant hands-on experience with LC-MS/MS instrumentation and bioanalytical method development.
- Demonstrated experience supporting Antibody-Drug Conjugate (ADC) bioanalysis.
- Experience working within a GLP-regulated CRO or pharmaceutical environment.
- Experience serving as a Principal Investigator, Senior Research Scientist, or comparable scientific leadership role.
- Strong scientific writing, data interpretation, and client communication skills.
- Ability to manage multiple studies while maintaining exceptional scientific quality and regulatory compliance.
Preferred Experience
Experience with one or more of the following is highly desirable:
- Large molecule LC-MS/MS assays
- Shimadzu and/or SCIEX instrumentation
- Watson LIMS
- FDA ICH M10 guidance
- Bioanalytical method validation in support of drug development
Why Join?
- Join a respected and growing preclinical CRO supporting innovative pharmaceutical and biotechnology companies.
- Play a highly visible scientific leadership role with direct client interaction.
- Work on cutting-edge therapeutics, including Antibody-Drug Conjugates and other advanced modalities.
- Collaborate with an experienced team of scientists in a GLP environment committed to scientific excellence.
- Competitive compensation, comprehensive benefits, and relocation assistance are available for qualified candidates.
Interested?
Apply directly or send your résumé to: View email address on us.fitly.work
Know someone who would be an excellent fit? We always appreciate referrals and would be grateful if you shared this opportunity with your network.
Vacancy posted 13 days ago
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