Executive Director, Global Trial Strategy & Operations

The Executive Director, Global Trial Strategy & Operations (GTSO) is a strategic operational leader accountable for driving disciplined execution, portfolio-level planning, and operational excellence within a designated Therapeutic Area, including CNS, TTR, or Hematology/Blood Disorders. Reporting to the Vice President, Global Trial Strategy & Operations, this role operates in close partnership with senior leadership to design and operationalize strategic priorities, ensure alignment to critical path milestones, and elevate delivery standards across studies. Responsibility includes shaping and advancing operational strategy through structured planning frameworks, portfolio insights, prioritization, governance, and cross-functional alignment to enable consistent, high-quality execution. The role influences execution across programs by partnering with program, study, and functional leaders to ensure operational strategies are robust, clearly documented, actively managed, and informed by risk, while driving milestone transparency, proactive risk identification and mitigation, and alignment to enterprise and portfolio priorities.

The Executive Director contributes to the evolution of Clinical Operations and the broader GTSO organization by developing and implementing scalable standards, best practices, and operating models that enhance efficiency, quality, consistency, and inspection readiness. Impact is achieved through strategic influence, establishment of clear expectations, and enablement of team effectiveness across a complex, matrixed environment.

Responsibilities

• Partner across Development study teams, and cross-functional partners to drive strategic operational planning, including defining approaches, execution assumptions, timelines, risk management strategies, and delivery frameworks.
• Develop portfolio-level tracking mechanisms, dashboards, KPIs, and performance analytics to support transparency and data-driven decision-making.
• Drive prioritization and scenario planning across their respective TA/s ensuring alignment to critical path and effective deployment of resources.
• Represent the portfolio in leadership and governance forums, ensuring continuity of strategy, alignment, and clarity of decision pathways.
• Develop, institutionalize, and continuously refine best practices, operating models, playbooks, and standards that reinforce planning rigor, predictable execution, and operational excellence.
• Partner with study and program leaders to ensure operational plans are documented, actively managed, and responsive to risks, external changes, and portfolio dependencies.
• Collaborate with peer and cross-functional leaders to support operational readiness, including inspection readiness, vendor oversight frameworks, and compliance.
• Contribute to Establish and evolve operating rhythms and governance structures that streamline communication, clarify accountability, and enable timely decisions across programs.
• Serve as a strategic thought partner to elevate execution focus, challenge assumptions, integrate lessons learned, and support continuous improvement.
• Partner closely with CROs and external vendors to ensure proactive execution, scope adherence, and high-quality delivery while establishing best practices for oversight.
• Assist in financial oversight across programs, including forecasting, budget management, investment planning, and long-range portfolio planning.
• Partner with SM&H, GTO, CPS, and other clinical operations groups to align strategies, improve processes, and drive portfolio delivery.

Qualifications

• Bachelor's degree in Life Sciences or related field required; advanced degree preferred.
• 15+ years of experience in global clinical trial execution within biopharma or CRO environments, with deep operational leadership across full study lifecycle.
• Experience with one or more of the following therapeutic areas is a must: Cardiovascular, CNS, or Hematology/Blood Disorders.
• Demonstrated success operating as a direct report to senior executives and partnering closely at the leadership level to translate strategic priorities into operational execution.
• Proven track record influencing without direct authority across senior operational and functional leadership.
• Expertise in clinical operations strategy, program planning, risk management, trial delivery models, and cross-functional execution.
• Experience developing or implementing operational frameworks, governance models, or delivery standards.
• Strong presence in senior forums with ability to synthesize complex information and drive alignment through compelling communication.
• Strong understanding of global regulatory expectations and compliance requirements for clinical trial conduct.
• Excellent written, verbal, and presentation communication skills.
• Ability to travel up to 30%.

U.S. Pay Range

$284,800.00 - $385,200.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website:

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.