Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Principal Scientist, Protein Formulation & DP Development

Denali Therapeutics Inc

Denali Therapeutics Inc in South San Francisco, CA, seeks a Principal Scientist to lead formulation and drug product development for a growing portfolio of protein biologics. You will design studies, establish shelf life, and support comparability across development stages. The role requires a PhD with 10+ years in DP/CMC for protein therapeutics, strong analytical skills, and hands-on LC-MS, HPLC, and cIEF experience. Collaboration with CMOs, QA, and other R&D teams is essential. #J-18808-Ljbffr Denali Therapeutics Inc

Vacancy posted 1 day ago
Similar jobs that could be interesting for youBased on the Principal Scientist, Protein Formulation & DP Development in South San Francisco, CA vacancy
  • $92.6k - $172k

     ...of Pharma Technical Development (PTD) our organization...  ...), clinical supply, formulation, device, packaging,...  ....The OpportunityThe Principal Associate Scientist ensures robust...  ...pharmaceutical processing are DP liquid filling and...  ...-on experience with protein processing, lab... 
    Principal
    Full time
    Local area

    Genentech

    South San Francisco, CA
    4 days ago
  • $159k - $207k

     ...to patients. We are seeking a Principal Scientist to join our Formulation & Drug Product Development team to serve as a formulation...  ...lead for our growing portfolio of protein biologics. This individual will...  ..., establish shelf life of DS & DP, assess in-use compatibility,... 
    Principal
    Contract work
    Local area

    Denali Therapeutics Inc

    South San Francisco, CA
    1 day ago
  •  ...highly skilled and hands-on Senior to Principal Scientist to join our Protein Science team. This role will focus...  ...deep bioconjugation and process development expertise to a novel therapeutic...  ...characterization, material requirements, formulation, and study timelines. Communicate... 
    Principal

    Myoventive, Inc.

    South San Francisco, CA
    5 days ago
  • Denali Therapeutics invites you to join our Formulation & Drug Product Development team as a Principal Scientist, leading formulation and DP development for a portfolio of protein biologics. You will work with analytical, bioprocess and QA to drive stability, compatibility... 
    Suggested

    Denali-Therapeutics

    South San Francisco, CA
    1 day ago
  • $140k - $250k

     ...Principal Scientist, Protein Sciences, Analytical Characterizations September 2025 Department: Technology Position Summary:...  ...Manage CROs and external collaborations on analytical development. Prepare precise technical summaries, protocols, and maintain... 
    Principal
    Full time
    Temporary work
    Flexible hours

    VALID8 Financial

    San Francisco, CA
    3 days ago
  • $175k - $200k

     ...currently developing a robust pipeline of novel protein‑drug conjugate therapies to better address...  ...Protein & Peptide/Chemical‑Protein Conjugate Formulation Scientist is a technical leader responsible for the development, optimization, and characterization of stable... 

    Valid8 Financial, Inc.

    South San Francisco, CA
    5 days ago
  • $177k - $235k

     ...) is an Alphabet-founded research and development company whose mission is to harness advanced...  ...:We are seeking an innovative Principal Scientist to bridge the gap between traditional...  ...years’ post-PhD experience in antibody/protein engineering within the biotech or biopharma... 
    Principal

    Calico Life Sciences

    South San Francisco, CA
    3 days ago
  • $167.4k - $310.8k

     ...transforming drug discovery and development. Roche’s Research and Early...  ...(AI) to assist our scientists in both pRED and gRED to deliver...  ...We are seeking a Senior or Principal Machine Learning Scientist to...  ...molecular modalities (e.g., protein sequences, chemical graphs,... 
    Principal
    Full time
    Local area
    Worldwide
    Relocation package

    Genentech

    South San Francisco, CA
    3 days ago
  • $155k - $180k

     ...biotechnology company pioneering the development of allogeneic chimeric antigen receptor...  ...:Allogene Therapeutics is seeking Principal Scientist, Cell Starting Material - Process Sciences...  ...viral transduction, cell expansion, formulation).Proven track record of leading... 
    Principal
    Full time
    Local area

    Allogene Therapeutics

    South San Francisco, CA
    2 days ago
  • $155k - $180k

     ...biotechnology company pioneering the development of allogeneic chimeric antigen receptor...  ...is seeking a highly motivated Principal Scientist to lead the Pilot Plant function within...  ...viral transduction, cell expansion, formulation).Experience supporting regulatory filings... 
    Principal
    Full time
    Internship
    Local area

    Allogene Therapeutics

    South San Francisco, CA
    3 days ago
  • $167.4k - $310.8k

     ...sciences are transforming drug discovery and development. Roche’s Research and Early Development...  ...Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative...  ...learning machine learning models for protein and antibodies in zero-shot and few-... 
    Full time
    Local area
    Worldwide
    Relocation package
    Shift work

    Genentech

    South San Francisco, CA
    3 days ago
  • $162k - $186k

     ...focused on the discovery, development, and commercialization of targeted protein degradation medicines,...  ...an experienced Senior Scientist to join the Analytical...  ...responsible for drug product (DP) analytical development...  ...for drug product formulations, including amorphous... 
    Contract work

    BioSpace

    Brisbane, CA
    1 day ago
  • $173.1k - $321.5k

     ...that we all have more time with the people we love.The Senior Principal Scientist serves as the scientific leader for Bioanalytical Strategy...  ...critical scientific questions that enable the successful development of cell therapy products. The Senior Principal Scientist will... 
    Principal
    Full time
    Local area
    Relocation package

    Genentech

    South San Francisco, CA
    1 day ago
  • $143.29k - $266.11k

    The PositionThis role is a vital part of our Cell Therapy Process Development team within Pharma Technical Cell and Gene Therapy Development (PTCC), which is committed to advancing next-generation cell therapies through innovative metabolomics research and media optimization... 
    Principal
    Full time
    Local area
    Relocation package

    Genentech

    South San Francisco, CA
    1 day ago
  • $202.8k - $376.6k

     ...sciences are transforming drug discovery and development. Roche’s Research and Early Development...  ...Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative...  ...frontier of AI for biology.As a Senior Principal Scientist, you will lead a team... 
    Principal
    Full time
    Local area
    Worldwide
    Relocation package

    Genentech

    South San Francisco, CA
    2 days ago
  • $144.9k - $269.1k

     ...sciences are transforming drug discovery and development. Roche’s Research and Early Development...  ...Intelligence (AI) to assist our scientists in delivering more innovative and transformative...  ...years equivalent experience after PhD (Principal Scientist). The ideal candidate will... 
    Principal
    Full time
    Local area
    Worldwide
    Relocation package
    3 days per week

    Genentech

    South San Francisco, CA
    4 days ago
  • $147.8k - $274.4k

     ...sciences are transforming drug discovery and development. Roche’s Research and Early Development...  ...Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative...  ...motivated and collaborative Senior/Principal Machine Learning Scientist to join the... 
    Principal
    Full time
    Local area
    Worldwide

    Genentech

    South San Francisco, CA
    11 hours ago
  • $201.3k - $373.8k

     ...and computational sciences are transforming drug discovery and development. Roche’s Research and Early Development organisations at...  ...power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative... 
    Principal
    Full time
    Local area
    Worldwide
    Shift work

    Genentech

    South San Francisco, CA
    1 day ago
  • $201.3k - $373.8k

     ...sciences are transforming drug discovery and development. Roche’s Research and Early Development...  ...Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative...  .... We're looking for an exceptional Principal Scientist who can architect how our... 
    Principal
    Full time
    Local area
    Worldwide

    Genentech

    South San Francisco, CA
    1 day ago
  • $201.3k - $373.8k

     ...and computational sciences are transforming drug discovery and development. Roche’s Research and Early Development organisations at...  ...power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative... 
    Principal
    Full time
    Work experience placement
    Local area
    Worldwide
    Relocation package

    Genentech

    South San Francisco, CA
    4 days ago
  • $90k - $210k

    South San Francisco, CAProcess Sciences - Process Development /Full Time /On-sitePosition SummaryWe are seeking an innovative and highly motivated Supervising Principal Scientist with expertise in cell therapy process development and people management. This individual... 
    Principal
    Full time
    Flexible hours

    Cellares

    South San Francisco, CA
    5 days ago
  • $91k - $130k

    Job Description Scientist I (Formulation Development) Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians... 

    Astellas

    South San Francisco, CA
    3 days ago
  • $200k - $240k

     ...possible to patients, and who lead with the desire to work on novel ideas. As a Principal Scientist, Potency, you will report to the Sr. Director, Head of Molecular and Potency Method Development. You will either lead or support the development and implementation of... 
    Principal
    Temporary work
    Work at office
    Immediate start
    Weekend work

    Sana Biotechnology

    South San Francisco, CA
    1 day ago
  • $180k - $215k

     ...Principal Scientist, Bioinformatics South San Francisco, California, United States Nkarta is a publicly traded (Nasdaq symbol NKTX)...  ...headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell... 
    Principal
    Work at office
    Flexible hours
    Shift work

    Nkarta Inc

    South San Francisco, CA
    2 days ago
  • $155k - $200k

     ...using experiments of unprecedented scale. This Position NewLimit is seeking a Senior/Principal Scientist with deep expertise in molecular biology and translational biomarker assay development. In this role, you will lead the discovery, development, and qualification of... 
    Principal

    Quiet Capital

    South San Francisco, CA
    3 days ago
  • Cytokinetics, Inc. in South San Francisco, CA, is seeking an Associate Scientist, Formulation Development, to advance small-molecule therapies across our development pipeline. You will manage internal formulation lab operations and support prototype formulation and drug... 

    Cytokinetics, Inc.

    South San Francisco, CA
    2 days ago
  • $121.5k - $141.75k

     ...patients suffering from diseases of cardiac muscle dysfunction. Cytokinetics is seeking a highly motivated Associate Scientist, Formulation Development, to contribute to the advancement of innovative small-molecule therapies across our development pipeline. In this role... 

    Cytokinetics, Inc.

    South San Francisco, CA
    2 days ago
  •  ...Astellas Pharma Inc. is seeking a Scientist I in Formulation Development to design, evaluate, and develop formulations and manufacturing processes for rAAV drug products. The role supports AGT’s pipeline with stability-focused formulation work for clinical use. The candidate... 

    Astellas

    South San Francisco, CA
    2 days ago
  • About the Role Onsite (South San Francisco, CA). Principal Scientist, Potency; reports to Sr. Director, Head of Molecular and Potency Method Development. Responsibilities Develop and qualify pivotal stage potency, immunoassay, and other cell-based methods to support characterization... 
    Principal
    Work at office

    Scorpion Therapeutics

    South San Francisco, CA
    2 days ago
  • $159k - $207k

    ## Principal Scientist, Commercial & Late-Stage Cell Culture Process DevelopmentApplylocations: South San Franciscotime type: Full timeposted...  ...technical activities for commercial and late-stage process development for Denali’s commercial and near-commercial biologics... 
    Principal
    Work experience placement
    Local area

    Denali Therapeutics

    South San Francisco, CA
    2 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Principal Scientist, Protein Formulation & DP Development. Be the first to apply!