PRINCIPAL SYSTEMS ARCHITECT, IS&T Research Computing
$150.4kBoston University
CategoryCharles River Campus --> Information TechnologyJob LocationBOSTON, MA, United StatesTracking Code26500998960407Posted Date4/7/2026Expected Hiring Range Minimum$150,400.00Expected Hiring Range Maximum$180,000.00The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, training and internal pay comparison. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.Position TypeFull-Time/RegularBoston University Information Services & Technology (IS&T) is seeking applicants with diverse skills and experiences to join our innovative and inclusive community. Join us as a Principal Systems Architect, where you will lead the design, development, and operations of Boston University's cloud-based research computing infrastructure, serving as the senior technical authority for IaaS, PaaS, and SaaS platforms that support data intensive research across multiple disciplines.You will combine deep hands-on operational expertise with strategic vision to architect next generation cloud systems whose impact will shape future University and communitywide research computing decisions. You will also oversee and advance major initiatives such as the New England Research Cloud (NERC) and its follow on projects, collaborating closely with partner universities and industry partners to develop shared research computing capabilities and standards. You will work closely with partner universities and industry partners to advance shared research computing goals.Required SkillsBachelor's degree or equivalent work experience. Experience: 7+ years of relevant experience.We are an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, natural or protective hairstyle, religion, sex, age, national origin, physical or mental disability, sexual orientation, gender identity, genetic information, military service, pregnancy or pregnancy-related condition, or because of marital, parental, or veteran status. We are a VEVRAA Federal Contractor.
$139.84k - $209.76k
...minds to make a real difference, there’s only one choice.Principal Scientist, Computational Designer (Biologics & Peptides) We are seeking a... ...and project leadership capabilities in cross‑functional research environmentsExpertise in protein and peptide structure modeling...PrincipalLocal area$142.5k - $256.5k
The Role:Moderna’s Therapeutics Research group is seeking a talented, experienced, and highly motivated Principal Scientist to support computational protein design across therapeutic research. This role will focus primarily on the design and optimization of T cell receptors...PrincipalPermanent employmentFull timeWork at officeWork from home$150k - $250k
...intersection of neuroscience and computation. We are developing next-... ...transform how intelligent systems are built. We believe that the... ...Neuromorphic Systems Architect to join our team. Leveling is... ...design.5+ years of relevant research or industry experience (level...PrincipalFlexible hours$95k - $275k
...Draper is an independent, nonprofit research and development company... ...Technologies Division is seeking a Principal Digital Engineering Solution Architect to apply systems-thinking and advanced... ...with modeling and simulation, computer language coding, descriptive modeling...PrincipalFull timeLocal area- ...Principal Computational Biologist Location: Boston, MA (Hybrid) This is an exciting opportunity to join a clinical-stage biotechnology... ...with the ability to collaborate across multidisciplinary research teams. This is a highly collaborative, hands-on role...PrincipalPermanent employmentFull time
$138.6k - $257.4k
...Pathology and Biomarkers group within Oncology Translational Research at Novartis Biomedical Research is seeking an accomplished Imaging... ...and technical leader with expertise in digital pathology, computational image analysis, AI/ML, and tissue-based oncology biomarkers....PrincipalFull time$148.5k - $214.5k
Job title: Senior Principal ScientistLocation: Cambridge, MAAbout... ...of our mast cell disorders Research & Development pipeline. A successful... ...understanding of the immune system - and innovative pipeline -... ...medicines.Familiarity with computational biology and broad range of ‘...PrincipalFull time$143k - $214.5k
...strategic Senior Scientist II or Principal Scientist, Sequencing... ...and AI/ML teams to enable key research objectives and accelerate innovation... ...data analysis workflows and computational methods. LOCATION: Cambridge... ..., our applicant tracking system, and may also be reviewed...Principal$148.5k - $214.5k
Job title: Senior Principal Scientist/Principal Scientist, Real-World... ...'s Target, Disease and Systems Biology (TDSB) team and become... ...Working alongside world-class computational and experimental scientists,... ...meets bold, AI-powered research. In R&D, you’ll drive breakthroughs...PrincipalFull time$270k - $300k
...and peak performance.We are seeking a Principal AI Researcher to join our Foundation AI team. This team... ...reported inputs to create scalable AI systems that understand human physiology and... ...at WHOOP, shaping the platform, compute, and infrastructure choices the team operates...PrincipalFull timeWork at officeRelocation- ...entertainment — provide a distinctive research environment: rich structured data, long... ...physics simulation engines, CAD kernels, and computational design tools give us something most... ...and preference optimization to agentic systems and long-horizon reasoningDevelop novel...PrincipalFor contractorsRemote work
- SummaryWe are seeking a Principal Systems Engineer to play a critical role in aligning engineering... ...development of large-scale quantum computers.This role sits at the intersection of... ...tools.Experience working closely with research or experimental teams.Exposure to quantum...Principal
$181.01k - $200.07k
...harness the body's natural protein recycling system to rapidly degrade disease-causing... ...collaboration with Biological Sciences, Computational Chemistry and Structural Biology colleagues... ...chemistry efforts at CROs (Contract Research Organizations). Critically analyzes data...PrincipalContract work- QUALIFICATIONSBachelor’s or master’s degree in computer science, engineering, or a related... ...command of data engineering, AI/ML systems, and deployment architecturesProven... ...and your family.WHAT YOU'LL DOAs a Principal AI Solution Architect at McKinsey, you will combine deep...PrincipalApprenticeshipImmediate startEasy workFlexible hours
$128k - $192k
...difference, there’s only one choice.Principal Machine Learning Scientist... ...activities, improving system performance through data analysis... ...(chemists, biologists, computational/data scientists, R&D leadership... ...related to drug development research, including biochemical,...PrincipalLocal area$122.25k - $176.58k
Job Title: Principal Scientist, Systems and Disease BiologyLocation: Cambridge, MAAbout the JobAs a Principal... ...Systems Biology function at Sanofi Research, is dedicated to delivering first-in... ...of innovative algorithms and computational models.Leading projects involving internal...PrincipalFull time$142.5k - $256.5k
...programs, and rapid maturation of computationally designed candidates.The... ...as well as other members of Research, to advance novel candidates... ...deploy scalable screening systems that replace resource-intensive... ...ownership consistent with a Principal Scientist role.Here’s What...PrincipalPermanent employmentFull timeWork at officeWork from home$169.8k - $355.4k
...Job Description The computer vision team is responsible for growing our capabilities in image analysis and recognition. Our goal is... ...learning, and image processing Proven track record of leading research and development projects Strong understanding of machine...PrincipalTemporary workFlexible hours$179k - $236k
...legacy of founding cutting-edge science and computational ventures, harnessing recent advances in... ..., and data to accelerate fundamental research and create a portfolio of AI-first... ...Pioneering Intelligence (PI) is building AI systems that accelerate translational decision...Principal$216k - $297k
...legacy of founding cutting-edge science and computational ventures, harnessing recent advances in... ..., and data to accelerate fundamental research and create a portfolio of AI-first... ...ambitious efforts to build polyintelligent AI systems that unify human scientific expertise,...Principal$179k - $236k
...documents; support agency interactions and responsesServe on the Research Leadership Team; represent DMPK and bioanalytical sciences in... ...application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We...Principal$142.5k - $256.5k
...seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics Research generates... ...partnering with antigen design, structural and computational biology, Immuno-oncology and Autoimmune Therapeutics...PrincipalPermanent employmentFull timeWork at officeWork from home- ...Job Title PROMETRIKA is a full-service clinical research organization (CRO) with extensive experience in clinical operations, data... ...preferred. Experience ~ Knowledge of SAS statistical computing package is a must. ~ Knowledge of other database management...PrincipalWork experience placement
$131k - $183k
...Description & Requirements The Principal Specialist, Research Security & Conflict of Interest Management... ...to the Director, this role is a key architect of the Institute’s Conflict of... ...data analysis, extensive reading, and computer-based workflows.Requires the ability...PrincipalFull timeWork at officeLocal areaFlexible hours$208k - $286k
...founding cutting-edge science and computational ventures, harnessing recent... ...to accelerate fundamental research and create a portfolio of AI... .... THE ROLE We are seeking a Principal Scientist (Embedded ML/... ...biomolecule design, multi-o, systems biology, and scientific literature...Principal$192.6k - $344.85k
...26WD94883Research Lead / Principal Scientist & ManagerPost-Training... ...reshaping how engineers, architects, and designers work-but... ...reliable, domain-capable systems is still an open research problem.Autodesk touches... ..., CAD kernels, and computational design tools give us something...PrincipalFull timeFor contractorsRemote work$170k - $225k
..., smart sensing, and human-centered computing. The resulting research and development help to continuously... ...researcher with experience in Human-Systems Integration, Human Factors, or Human... ...development contracts or grants as a Principal Investigator, Technical Lead, or...Work experience placementCasual workRemote work3 days per week$170k - $220k
..., smart sensing, and human-centered computing. The resulting research and development help to continuously... ...projects, from enhancing autonomous systems to pioneering health diagnostics to... ...tightly-knit, project-oriented teams as a Principal Investigator with other scientists...Work experience placementCasual workWork at office$121.28k - $202.13k
...combining our understanding of the immune system with cutting-edge technology to... ...enforce good engineering practices in our research—utilizing code architecture planning, clean... ...experience) in a quantitative field (Applied ML, Computer Science, Physics, Systems/Computational...PrincipalFull timeWork at officeLocal areaRemote workRelocation$133.5k - $192.83k
Job Title: Research and Development Solution Architect - Digital Lab OperationsLocation: Morristown, NJ -Cambridge... ...Our deep understanding of the immune system - and innovative pipeline - enables... ...’s and/or Master’s degree in Computer Science, Information Systems, Software...Full time
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