Senior Manager, Operational Excellence, Cell Therapy

Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

At Bristol Myers Squibb we are reimagining the future of cell therapy. With our bold ambition, backed by a best-in-the-industry team and long-term commitment, we are leading the way to unlock the full promise of cell therapy as we strive to put more patients on the path to a cure. If you are ready to challenge yourself, accelerate your career, and give new hope to patients, there's no better place than here at BMS with our Cell Therapy team.

The Senior Manager, Operational Excellence, Cell Therapy is responsible for performing functions to apply techniques and principles that will improve the end-to-end operations and supply chain processes that will deliver best in class safety, quality, productivity and cost across the Cell Therapy value streams. This position is intended for someone with organizational curiosity and will think beyond the current status quo. Using lean/six sigma techniques, the person in this role will drive improvements both individually and through cross functional teams for cell therapy products for both global clinical trials and commercial supply.

The Senior Operational Excellence Manager will require knowledge and experience with the Toyota Production System as well as Policy Deployment (Hoshin Kanri) implementation. In addition, this role will be responsible for documenting value stream and process maps, and monitoring/improving key performance indicators to ensure business goals are achieved.

Shifts Available:

M - F, Standard Working Hours

Responsibilities may include, but are not limited to the following:

• Build the Operational Excellence Structure and Governance for the Devens Facility.

• Develop Policy Deployment (Hoshin Kanri), Value Stream Maps, Visual Management Systems and other key lean tools.

• Grow the Operations Excellence maturity level in the organization.

• Analyze and identify process improvement opportunities and partner with key stakeholders to scope and ensure alignment with strategic priorities.

• Evaluate and establish processes and systems with the goal of improving product quality, throughput/capacity reduce costs, and/or reduce lead-time and cycle times.

• Utilize business intelligence tools (e.g tableau,) and conducting advanced analytics to improve key performance metrics to achieve future desired operational capability and growth.

• Utilize simulations software (e.g Arena, Promodel) to create models to identify resources needed to support operations and identify opportunities to improve overall resource utilization and capacity.

• Identifies required resources including personnel, tooling, equipment, facilities, work-in-process and production.

• Create and maintain capacity models, simulation models, and proactively drive capacity solutions.

• Establishes work measurement programs and analyzes work samples to develop labor standards.

• Analyzes work force utilization, facility layout, and operational data such as production costs, process flow, headcount and production schedules, to determine efficient utilization of worker and equipment.

• Support project teams, prepare project schedules, coordinate the execution of technical projects and develop presentations to disseminate results to project stakeholders and senior management.

• Implement methods for improving efficiency and reducing waste of raw materials and utilities.

• Design and facilitate kaizen/workshops to understand current processes, conduct route cause analysis investigation, design future state and develop change plans.

• Conduct Gemba style process documentation and diagnostic activities.

• Collect, consolidate, and analyze data and information, present it in a format that brings information to life and therefore supports effective decision making.

• Work across all levels, from business leaders to front-line staff, to identify business impacts and support the development of change plans.

• Participate in team meetings and contribute to the development of Process Excellence tools and methods.

• Run internal projects (e.g. Project initiation, planning, scope, funding requests, approvals, execution and closeout).

• Direct multidisciplinary project teams to ensure delivery of the project on time, on budget and to pre-defined quality level. Prepare project schedules, coordinate the execution of technical projects and develop presentations to disseminate progress, risks and status to project stakeholders and senior management.

• Work closely with Engineering /Maintenance on the design and implementation of new technology and new systems/facilities related to production process needs.

• Foster strong inter-team relationships to achieve common project goals.

• Support monitoring, analyzing, and optimizing the end-to-end process and anticipate and permanently resolve issues that may arise during production.

• Provide investigation support for production related investigations, ensuring compliance with internal standards and regulatory requirements.

• Design and execute test plans and other risk mitigation exercise as part of investigations (e.g. Root cause analysis and CAPAs).

• Support inspection readiness and actively support regulatory inspections and ensure safe and compliant cGMP operations.

• Review and revise the content of technical documentation (e.g. investigations, changes, SOPs and batch records).

• Support the tracking of team metrics and manage completion of objectives and projects.

• Drive changes across the organization.

Leadership:

• Promote a mindset of continuous improvement, problem solving, and prevention.

• Create an environment of teamwork, open communication, and a sense of urgency.

• Support the change agent in promoting flexibility, creativity, and accountability.

• Support organizational strategic goals and objectives that are linked to the overall company strategy.

• Drive strong collaboration within the plant and across the network.

• Build trust and effective relationships with peers and stakeholders.

• Deliver business results through timely and quality decision making and advice.

• Foster a culture of compliance and strong environmental, health, and safety performance.

Knowledge, Skills & Abilities:

• Experience of successfully implementing and sustaining a Lean/Continuous Improvement Culture and Platform.

• Successful and demonstrable track record delivering end-to-end (from conception to benefits realization) process improvement initiatives.

• Experience with Hoshin Kanri or Policy Deployment systems implementation.

• Development of Value Stream Maps, Visual Management Systems and other lean tools.

• Solid understanding of Engineering, Project Management, Lean Principles, Six Sigma, Financial acumen.

• Vast experience with application of Operational Excellence and Lean Manufacturing principles.

• Experience with Project Management and Change Management principles.

• Solid understanding of cGMP's and multi-national biopharmaceutical/cell therapy regulations.

• Experience working with external parties and/or leading cross-functional teams.

• Possess strong verbal/written communication skills and ability to influence at all levels.

• Ability to think strategically and to translate strategy into actions.

• Ability to prioritize and provide clear direction to team members in a highly dynamic environment.

Minimum Requirements:

• Bachelor's degree of Engineering/Business/ Science or related discipline.

• Lean Six Sigma Black Belt required/Lean Six Sigma Black Belt from an accredited institution preferred.

• Minimum 8 years of Operational Excellence experience in the Biotech/pharmaceutical industry - Cell Therapy preferred.

Travel:

• This position requires up to 10% of travel.

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If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview:

Devens - MA - US: $137,790 - $166,973

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical, pharmacy, dental, and vision care.

• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).

• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)

• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

* Eligibility Disclosure: T he summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to View email address on click.appcast.io . Visit careers.bms.com/ ( eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information:

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If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at View email address on click.appcast.io . Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley.

R1601911 : Senior Manager, Operational Excellence, Cell Therapy Company: Bristol-Myers Squibb

Req Number: R1601911

Updated: 2026-05-30 05:39:50.510 UTC

Location: Devens-MA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.