Sr. Scientist - Mass Spec Development (LC-MS/MS)

Overview Performing critical work that impacts our industry and our world’s health while problem solving and innovating in the field – that is what Sr. Scientists at KCAS Bio get to do every day. If that excites you too, then maybe working as a Sr. Scientist at KCAS Bio is the role for you. When you work as a Sr Scientist in the Mass Spec Bioanalysis Development group at KCAS, you get to further our mission by leveraging your knowledge in bioanalytical and scientific principles to be responsible for carrying out all aspects of a study, from study setup through reporting, as well as development. You will also utilize your strong base in scientific principles/theories to assess data integrity and troubleshoot when necessary. Our Mass Spec Bioanalysis Development team uses LCMS (Liquid Chromatography Mass Spectrometry) techniques to conduct sophisticated sample preparation to meet bioanalytical needs for drug discovery, preclinical, and clinical studies, including bioanalysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues. Responsibilities Design and execute all phases of assigned projects including sample preparation (extractions, enrichments/affinity capture, digestions), method development and qualification for LCMS, troubleshooting, data analysis, and report generation. Act as lead scientist, help to design experiments, provide work instructions and technical training to more junior scientific staff in daily activities. Be responsible for all client communication related to study conduct. Interact with QAU to resolve identified audit issues and be accountable for continuous quality management in assigned studies. Have final authority for sample identification, including clinical site discrepancies and/or client. Be responsible for timeline adherence and communication of status to management as required. Ensure compliance of study activities with pertinent portion of study protocol, SOPs & regulatory requirements. Be able to set up and change instrument configurations for various LCMS methods. Prepare data summaries for senior scientists to aid in client updates. Act as a technical expert for all aspects of process design and problem solving. Perform all aspects of the job in a way that supports company brand and mission, vision, and values. Qualifications Bachelor’s, Master’s, or PhD in Chemistry, Biochemistry or chemical/biochemical engineering, or related field with at least 5 years of experience with LC-MS/MS 2-3 years of experience in a Principal Investigator role Bioanalytical sample preparation, Quantitative LC-MS/MS, and multi-dimensional chromatography Experience with proteins and peptides as well as small molecule biomarkers is preferred Experience with Reversed Phase and Hilic chromatography at the analytical and micro/nano flow rates or protein digestions and immunoaffinity enrichments (hybrid LCMS) is a plus About KCAS Bio Please note this is a representative summary of responsibilities, not a comprehensive or exclusive list of the duties to be performed in any position. Employees must follow instructions and perform additional duties as requested. Who you are You will thrive at KCAS Bio if you enjoy a relational environment, are purpose- and values-driven, embrace constant development and supportive leadership, and enjoy being part of innovative work. What you’ll get Our benefits include, and extend beyond, the traditional package. At KCAS Bio, you will enjoy company sponsored events like food trucks, family days and spirit days. You will grow in your career with KCAS University. You will be able to connect with like-minded employees to further KCAS Bio\'s approach to key areas such as wellness, inclusion, and community outreach. You will engage as an owner in our stock ownership program. You will have access to the latest technology. And you will be able to invest in the community with paid time off to volunteer. Who we are We are a fast-growing contract research organization (CRO) headquartered in Kansas City, pioneering the latest drug development in both human and animal health fields. Demand for our expertise is growing and so is our need for great people to work in nimble, empowered teams committed to one another’s growth. At KCAS Bio, we advance both great science AND great people. KCAS Bio is proud to be an Equal Opportunity Employer. Among other things, we provide equal employment opportunities without regard to race, color, religion, national origin, ancestry, marital status, veteran status, age, disability, pregnancy, genetic information, sex, sexual orientation, gender identity, or any other legally protected category; we recruit qualified candidates without regard to citizenship status based on internal processes that enable us to hire the right candidates consistent with the appropriate U.S. Immigration framework; and we work with and provide reasonable accommodations to individuals with disabilities and for sincerely held religious beliefs, observances, and practices. Anyone who needs reasonable accommodation may contact our Human Resources department for assistance. #J-18808-Ljbffr KCAS Bio