Associate Principal Scientist, Downstream Process Development

Job Description The Biologics Process Research & Development organization within our company's Research Laboratories is responsible for developing the drug substance manufacturing processes for our company's biologics pipeline. We work closely with colleagues in Discovery, Pre‑clinical and Early Development to rapidly develop manufacturing processes for biotherapeutics and efficiently manufacture material to supply clinical trials. We are also responsible for commercial process development and the development and implementation of new manufacturing technologies. We work with our partners in the company's Manufacturing Division to commercialize and launch new products. Job Overview We are seeking a highly motivated and experienced individual to join our Downstream Process Development and Engineering group as an Associate Principal Scientist. In this role, you will work with a highly collaborative team of scientists and engineers to design and develop downstream purification processes in support of early and late‑stage biological products. The scope and activities include designing and optimizing downstream unit operations such as cell harvest, filtration, chromatography, viral clearance, precipitation, crystallization, and continuous processing for batch and intensified/continuous bioprocesses. The role will also require effective organisational and multitasking skills and strong communication skills, both verbal and in presentation of data. Responsibilities Leading biologic downstream process development for first‑in‑human and commercial processes by efficiently developing high‑yield, robust and scalable processes. Independently designing and conducting experiments using relevant operational parameters and analytical inputs. Providing technical supervision for process development and characterization. Collaborating with upstream process development, Biologics Analytical R&D, and other cross‑functional teams in both Research and Manufacturing to advance the biologics pipeline. Advancing downstream platform process technical strategy, and championing creative process improvement initiatives. Assessing new technologies, sciences, and industry strategies and relevance to our company. Collaborating with academia, industry partners, and vendors to drive development, innovation and adoption of new process technologies. Keeping up to date with the external patent and literature environment; actively presenting and publishing externally and pursuing patenting strategies. Mentoring junior scientists. Education Requirements Ph.D. with 3+ years of industry experience or Master with 6+ years industry experience or BS with 8+ years in industry experience in Chemical Engineering, Biochemical engineering, or a related field. Required Skills Proven record of accomplishments in downstream process and technology development with a scientific publication and presentation track record. Scientific understanding of the engineering principles for recombinant protein purification unit operations. Proven ability to design and execute protein purification experiments independently. Ability to direct the planning, execution, analysis, and documentation of all stages of downstream process development. Ability to work in a matrixed team environment and collaborate with both internal and external partners including vendors. Knowledge of biologics CMC development cycle. Demonstrated ability to take initiative, creativity, and innovation in problem solving. Preferred Skills Experience with high‑throughput experimentation using automation platforms such as TECAN. Experience using and/or programming process control systems such as DeltaV and PCS 7. Experience with integrated and continuous processing and equipment including multi‑column chromatography systems (BioSMB, PCC, or similar). Background or experience in data science approaches related to downstream processes and predictive modeling (multivariate data analysis, machine learning/artificial intelligence, leveraging PAT). Salary Salary range: $142,400.00 – $224,100.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of posting. An employee's position within the range will be based on several factors including, but not limited to, relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. Benefits We offer a comprehensive package of benefits, including medical, dental, vision health and other insurance benefits for employee and family, retirement benefits including 401(k), paid holidays, vacation, and compassionate and sick days. More information is available at Equal Employment Opportunity Statement As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights, EEOC GINA Supplement. Location and Availability US and Puerto Rico residents only. Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please contact us if you need an accommodation during the application or hiring process. San Francisco residents only – We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance. Los Angeles residents only – We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance. Other Job Details Employee status: Regular Relocation: Domestic Visa sponsorship: Yes Travel requirements: 10% Flexible work arrangements: Not applicable Shift: Not indicated Valid driving license: No Hazardous material(s): N/A Job posting end date: 05/26/2026 #J-18808-Ljbffr