Medical Director, Medical Affairs

Medical Director, Medical Affairs

Hybrid/San Francisco, CA & Palo Alto, CA

Mavericks Wanted

When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a "moneyball for biotech" approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.

What You'll Do

The Medical Director, Medical Affairs is a senior medical and scientific leadership role within Medical Affairs. This role is responsible for supporting the development and execution of the medical strategy for encaleret across clinical development programs, including autosomal dominant hypocalcemia type 1 (ADH1) and chronic hypoparathyroidism. The position is critical to advancing scientific engagement, evidence generation and dissemination, clinical development support, and lifecycle planning, and to preparing for United States launch and post marketing activities.

The Medical Director, Medical Affairs will serve as a key cross-functional partner, providing medical expertise and strategic leadership and partnership across Clinical Development, Regulatory, Commercial, Patient Advocacy, and Field Medical. This role will also represent BridgeBio externally with investigators, key opinion leaders (KOLs), patient organizations, and the broader scientific community.

Responsibilities

• Support development and execution of the United States Medical Affairs strategy for encaleret in ADH1 and chronic hypoparathyroidism, and support Medical Affairs launch readiness and lifecycle planning, serving as an internal medical expert with scientific rigor and patient focused decision making
• Lead integrated evidence generation planning and manage execution, including real world evidence generation, Phase 4 studies, registries, investigator initiated research support, and data integration activities
• Lead an omnichannel Health Care Professional engagement strategy, integrating field and digital scientific exchange to gather insights and inform internal Medical Affairs programs
• Build and sustain strategic relationships with key opinion leaders, investigators, and external stakeholders across endocrinology, nephrology, and related specialties, and lead advisory board and expert panel planning and execution
• Partner with Clinical Development to support ongoing and planned clinical trials and contribute to scientific data disclosure and publication strategy development in collaboration with Scientific Communications
• Provide medical leadership for peer to peer scientific exchange and external education programs, including scientific presentations and representation at scientific congresses, clinical meetings, and external forums
• Serve as medical reviewer and approver for medical, commercial, and patient advocacy materials, and support patient finding initiatives and Field Medical strategy and training in partnership with cross functional stakeholders, ensuring compliance with applicable regulations and internal Medical Affairs policies

Where You'll Work

• This position is hybrid/on-site role (San Francisco Bay Area)
• Ability to travel up to ~40% for scientific meetings, advisory boards, and internal engagements

Who You Are

• MD, DO, PharmD, PhD, or equivalent advanced scientific or clinical degree
• 5+ years of experience in Medical Affairs, Clinical Development, or related roles within the biopharmaceutical industry and/or academic medicine
• Deep experience in endocrinology, rare diseases, or metabolic disorders strongly preferred
• Demonstrated experience supporting late-stage development, launch preparation, and post-marketing medical activities
• Strong scientific and clinical acumen with the ability to translate complex data into clear medical insights
• Proven leadership and influence in cross-functional, matrixed environments
• Excellent written and verbal communication skills
• Strong understanding of regulatory and compliance requirements impacting Medical Affairs and field activities
• Ability to work independently in a fast-paced, evolving organization
• Strategic mindset with hands-on execution capability
• You have demonstrated curiosity and adaptability in adopting AI-powered tools and technologies

Salary

$220,000 - $315,000 USD

As a global company, our comprehensive benefits may vary based on location. We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return.

For Full-Time U.S Based Roles:

Financial & Rewards

• Market-leading compensation
• 401(k) with employer match
• Employee Stock Purchase Program (ESPP)
• Pre-tax commuter benefits (transit and parking)
• Referral bonus for hired candidates
• Subsidized lunch and parking on in-office days

Health & Well-Being

• 100% employer-paid medical, dental, and vision premiums for you and your dependents
• Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA)
• Fertility & family-forming benefits
• Expanded mental health support (therapy and coaching resources)
• Hybrid work model with flexibility
• Flexible, "take-what-you-need" paid time off and company-paid holidays
• Comprehensive paid medical and parental leave to care for yourself and your family

Skill Development & Career Paths:

• People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility
• We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching
• We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities