Senior Clinical Trial Manager

Radiopharmaceuticals are one of the fastest-growing and most strategically active segments in biotech and Actinium Pharmaceuticals (NYSE: ATNM) is at the forefront. Actinium is building first-in-class targeted radiotherapies by uniquely integrating deep radiochemistry expertise with cancer biology insight. Our pipeline spans solid tumors and hematologic malignancies and includes multiple platform-level partnering opportunities across alpha-emitter therapeutics, combinations, conditioning agents, and manufacturing IP. This role sits at the center of that inflection point owning the execution of complex, global early-phase oncology trials with the precision, urgency, and leadership required to translate scientific innovation into clinical and strategic impact. The Opportunity As Sr. Clinical Trial Manager, you will lead the end-to-end execution of global Phase 1/2 oncology trials, ensuring high-quality data delivery on accelerated timelines. You will own global study operations from start-up through database lock, translating program strategy into executable plans while driving performance across sites, CROs, and vendors. This is a highly visible, hands‑on leadership role operating at the intersection of Clinical, Regulatory, CMC, and Translational teams. You will act as the true study owner—accountable for timelines, data quality, and operational success—while partnering closely with executive leadership on program‑critical decisions. Key Responsibilities Lead global Phase 1/2 oncology trial execution from study start-up through database lock Drive timeline acceleration across enrollment, site activation, and imaging-to-treatment intervals Translate program strategy into detailed, executable clinical operational plans Own CRO and vendor relationships, ensuring accountability, performance, and high-quality delivery Proactively identify operational risks and implement mitigation strategies to maintain timelines Partner cross-functionally with Clinical, Regulatory, CMC, and Translational teams to ensure alignment Ensure delivery of clean, timely, and decision-ready data for internal and board-level stakeholders Optimize site performance and enrollment strategies across global trial footprints Contribute to continuous improvement of operational processes, including adoption of AI-enabled workflows Support executive-level reporting and program updates tied to key development milestones What You Bring Proven track record leading global Phase 1/2 oncology trials in a fast‑paced biotech environment Experience with complex early-phase designs (FIH, dose escalation, imaging-driven, combination studies) Demonstrated ability to accelerate timelines and solve operational challenges proactively Strong ownership mindset with the ability to operate independently and drive outcomes Deep understanding of GCP and global clinical/regulatory execution Excellent cross-functional leadership and stakeholder management skills Ability to translate complex clinical operations into clear insights and actions for leadership Education Bachelor’s degree required (life sciences or related field) Advanced degree (MS, PhD, or MBA) preferred Actinium is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of protected Veterans status, individuals with disabilities status, and consistent with all federal, state or local laws. #J-18808-Ljbffr Actinium Pharmaceuticals, Inc.