Bioinformatics Scientist (52646)

Description

Position Objective: The Bioinformatics Scientist will independently provide computational and analytical support services to advance the institutes research objectives for the National Institute of Environmental Health Sciences within the National Institutes of Health. This role will support

study design data processing advanced modeling and interpretation of results to generate meaningful insights into neurobehavioral mechanisms. The position will also contribute to the development of scalable analysis pipelines reproducible workflows and innovative computational strategies that enhance the institutes research capabilities and scientific impact.

Duties and Responsibilities:

• Generate and optimize programs and scripts for the analysis of data; create programs and algorithms and develop computational infrastructure resources for organizing and parsing data from large and complex data.
• Serve as bioinformatics expert and coordinate with teams of biologists to conduct experimental queries and/or perform portions of studies using complex procedures and techniques common to modern bioinformatics.
• Coordinate building bioinformatics infrastructure to ensure easy and meaningful scientific analysis and interpretation of data.
• Provide broad-based programming and analytic support for a wide variety of bioinformatic and research projects.
• Install troubleshoot and run open-source and commercial scientific software on platforms
• Conduct analyses of in vivo neurobehavioral data; independently design the analytical approaches as well as identify and solve scientific or technical problems. 1
• Support to the Neurobehavioral Core Laboratory to develop custom pipelines for raw data acquisition management pre-processing post-processing and interpretation. 3
• Performs computations on research data analysis.
• Provide reports based on analysis of scientific data.
• Provide interpretive analyses of data derived from different experimental platforms to generate biological meaning.
• Write custom programs and algorithms to support data analyses and discovery.
• Analyze large-scale neural and behavioral datasets using machine learning and statistical approaches. 4
• Implement algorithms for data processing and visualization optimizing them for performance. 5
• Collaborate with scientists to design analyze manage and interpret all types of data.
• Work with staff on planning of experiments and data analysis for internal and collaborative projects; use bioinformatics expertise to advise and help bench scientists on experimental design and trouble-shooting.
• Work with staff to develop specifications for new analysis; design test and implement solutions.
• Make recommendations to investigators about the correct computational tools for testing scientific hypotheses and reaching valid conclusions.
• Collaborate with the Neurobehavioral Core Laboratory and support scientists to recommend the computational approaches for testing hypotheses analyze and interpret in vivo neurobehavioral data; prepare and present the results based on the scientific objectives. 2
• Maintain proper and detailed documentation of the analysis performed and report results at lab meetings.
• Attend scientific and programming meetings; take and compile comprehensive notes; organize and edit content of meeting reports.
• Prepare scientific reports and progress reports; assemble data to prepare tables graphs and slides; conduct scientific and program related information searches and report results.
• Organize daily laboratory notebook on experiments; prepare weekly updates on on-going experiments and tasks; provide monthly
• progress notes on assigned projects; submit final progress reports and future directions on projects.
• Organize laboratory notebook or computer database to record results of calculations. Share results at lab meetings.
• Devise novel methods of statistical analysis for collected data.
• Utilize and adapt existing bioinformatics techniques to check for trends and patterns in the data.
• Perform data processing and data analysis with existing computational and statistical methods.
• Assist in evaluating and interpreting results for validity and scientific meaning.
• Create novel programs and algorithms that facilitate discovery of knowledge in investigating large and complex data.
• Develop and optimize programs and scripts that facilitate organization integration and data-mining of large data sets; integrate these models into a framework of best practices.
• Participate in the design of new protocols involving computational methods.
• Work with staff on the development and maintenance of bioinformatics tools scripts and pipe-lines for data.
• Participate in research design with investigators for determining best practices pertaining to the bioinformatics analysis in new and ongoing projects.
• Research and review literature to retrieve targeted clinical or scientific information including novel statistical methods from publicly
• available resources.
• Collaborate with staff to review current and historical procedures for the acquisition quality control and management of data.
• Analyze and evaluate data cleaning and harmonization needs in the using a variety of descriptive statistics and analytic methods.
• Identify new tools and resources for reaching biologically meaningful conclusions.
• Collaborate with experimentalists and computational biologists to develop new computational tools to answer research questions of interest.
• Independently coordinates the training of personnel in the use of scientific software applications statistical software applications and programmatic software applications.
• Provide training in and technical support (including product updates and version control) for programs algorithms archives and pipelines generated during the course of this work.
• Instruct staff in computational analysis of data.
• Provide ad hoc trainings and hands-on workshops on the use of bioinformatics tools.
• Provide training of students new investigators and other laboratory personnel in the use of techniques procedures and equipment to complete the objectives of the laboratory.
• Provide ad hoc trainings and hands-on workshops on the use of computational in vivo neurobehavioral tools.
• Initiates interdisciplinary collaborations with other research centers.
• Work with an interdisciplinary team to apply computational data analysis approaches to make biological discoveries.
• Collaborate with group members in experiments associated with data collection.
• Interact with all levels of staff and communicate with outside collaborators in the US and abroad.
• Work with staff collaborate with outside researchers and contribute to positive overall teamwork; teach Bioinformatics principles and methodologies.
• Collaborate with biologists statisticians and/or other bioinformaticians in the design of models summarizing/explaining experimental data.
• Present new research data in group settings at meetings or seminars.
• Work products and documents related to supporting scientific research projects: provide consultations for experimental design; conduct routine data analyses; develop and per-form customized analytical strategies for each project; deliver the summary reports and visualization of results; assist with results interpretation; present results in team settings; and contribute to scientific manuscript preparation.
• Work products and documents related to supporting the Neurobehavioral Core Laboratory and internal groups: assist with raw data acquisition management and pre-processing; assist with troubleshooting for instrument run issues data processing issues and sample performance issues; establish and maintain high throughput data processing and analysis systems; evaluate commercial software and open source software.
• Work products and documents related to scientific research development: assist with the design and development of major in vivo neurobehavioral programming projects for scientists; write custom scripts to access databases and analyze data; develop novel analytic methodology to meet the demands from rapidly evolving intramural scientific research.
• Work products and documents related to training and outreach: provide training for scientists in in vivo neurobehavioral data analyses and interpretation; train scientists in the selection and use of in vivo neurobehavioral bioinformatics tools; assist with the preparation and teaching of courses and/or demonstrations on the use of these tools; provide technical expertise for these software and tools .

Basic Qualifications:

• Masters in Neuroscience Computational Biology Computer Science Physics Mathematics or a related field.
• Machine Learning Certification
• Skilled in SQL R Image J Python MATLAB Linux Shell PERL Unix Java and HPC
• Experienced in Neurobehavioral imaging data analysis working with large data sets Cloud-Based Computing Pipeline development and Multi-omics Analysis
• Skilled in Machine Learning Image Analysis Core facility Neural data analysis and Behavioral data analysis

Preferred Qualifications:

• Ph.D. in Biological Sciences NeuroScience Bioinformatics Biostatistics Computational Biology or a related discipline preferred
• Ability to communicate effectively orally and in writing with non-technical and technical staff
• Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects

To perform this job successfully an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge skill and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job email us at . You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.

Qualified applicants will receive consideration for employment without regard to race color religion sex national origin disability protected veteran status or other characteristics protected by law.

This position is contingent upon contract award.

Required Experience:

Senior IC