Research Fellow Center for Genomic Medicine

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Musolino Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, is seeking highly motivated post-doctoral Research Fellow candidates. At the Musolino laboratory we are dedicated to the development and application of innovations in gene therapy technologies for rare vascular conditions. The candidate will be expected to have experience, or high capacity to learn, mammalian cell culture, CRISPR/Cas9 genome editing, murine modeling, and various molecular genetic techniques. The team will include the Principal Investigators and other faculty, research scientists, postdoctoral fellows, and research technicians and technologists. In this position we are seeking a Research Fellow with the enthusiasm to develop projects that will contribute to diverse and highly collaborative research programs. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and at the Harvard Medical School.

PRINCIPAL DUTIES AND RESPONSIBILITIES

Perform CRISPR-based genome editing using established protocols Perform molecular genomics procedures as needed (i.e., DNA/RNA extraction, library production, RNAseq, sample archiving, tissue culture, etc.) Design, execute, and interpret research experiments Learn any number of molecular genomics techniques including single-cell RNAseq (scRNAseq), ATACseq, ChIPseq, HiC, and other methods Routinely check medium, reagents, and plasticwares for cell culture experiments Maintain mouse colonies and process murine tissues for phenotypic evaluation Perform noninvasive and invasive hemodynamic assessments of mouse models of human disease Maintain laboratory notebook Independently follow detailed protocols while working closely with a wide range of lab members (i.e., graduate students, postdocs, technicians, staff scientists) Assist in training new Research Technicians and Fellows Responsible for troubleshooting problems and instructing others in highly specialized techniques. Investigate, create, and develop new methods and technologies for research advancements. Preparation of written data reports, including methodology, figure preparations, written description of the study in the form of manuscripts and/or progress reports. Contribute to research presentations at local, national, and international meetings. Oversight of laboratory technicians participating on the projects, including training them, and assisting them with experimental design and implementation. Compose and present sections of research reports. Organize and/or draft material for the preparation of research papers, manuscripts, or other documents for publication and/or presentation. The Research Fellow will be situated in the MGH under the guidance and mentorship of Dr. Patricia Musolino. Qualifications

SKILLS & COMPETENCIES REQUIRED

First (or co-first) author of one or more peer-reviewed scientific publications Excellent English verbal and written communication skills Able to work both independently and in a team Experience with delivery of genomic therapies such as LNPs and/or genome editing- required. Experience in molecular genomic techniques (i.e., PCR, qPCR, RNAseq, gel electrophoresis) Experience in mammalian cell culture- required Interest in learning and troubleshooting new molecular biology techniques Familiarity with animal modeling of disease - required Excellent organizational and communication skillsSound interpersonal skills and the ability to supervise and train staff effectively. Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab. Ability to function with speed, precision, and an understanding of theory behind protocols and experiments.

EDUCATION

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