Overnight Histotechnologist (Immunohistochemistry)

About Us:

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe.

Exciting Opportunity: We are currently seeking an overnight Histotechnologist to join our Immunohistochemistry team .

Role Overview

The IHC Histotechnologist will support daily Immunohistochemistry laboratory operations, including specimen preparation, technical testing, quality control, instrument maintenance, troubleshooting, validation, and compliance with regulatory and departmental requirements.

Responsibilities include:

• Section paraffin tissue specimens as requested.

• Perform Immunohistochemistry techniques, including embedding, microtomy, tissue processing, reagent preparation, antibody staining, and antibody reactivity review.

• Perform and document IHC quality control activities according to laboratory procedures.

• Assist with IHC instrument maintenance, including daily setup, shutdown, cleaning, routine maintenance, and troubleshooting.

• Analyze and troubleshoot equipment-related, staining-related, reagent-related, and workflow-related issues in a timely manner.

• Assist with lot-to-lot validation, antibody validation, optimization, and troubleshooting.

• Maintain accurate quality control, quality assurance, validation, and maintenance records.

• Support compliance with FDA, CAP/CLIA, NYS, and Joint Commission requirements.

• Adapt to updated workflows, procedures, and operational changes with an open mind and in a timely manner.

• Work collaboratively with supervisors, leads, pathologists, and team members to support patient care, laboratory quality, and turnaround time.

Key Qualifications

• Bachelor's degree or equivalent in Medical Technology, Clinical Laboratory Science, Biology, Chemistry, or a related field.

• NYS Clinical Laboratory Technologist license, Certified Histological Technologist license, or eligibility to obtain NYS licensure required.

• Prior experience in Histology and/or Immunohistochemistry is strongly preferred.

Core Skills

• Knowledge of instruments used in Immunohistochemistry.

• Knowledge of Immunohistochemistry antibodies, staining patterns, and antibody reactivity.

• Ability to perform dilutions and laboratory calculations accurately.

• Ability to assist with antibody optimization, validation, lot-to-lot validation, and troubleshooting.

• Ability to perform IHC quality control and maintain complete documentation.

• Ability to perform routine IHC instrument maintenance and recognize instrument-related issues.

• Strong troubleshooting skills related to staining quality, instrument function, reagents, and workflow.

• Excellent organizational and time-management skills.

• Strong digital literacy, including working with laboratory databases and computer systems.

• Strong problem-solving skills, with the ability to manage complex, high-volume, and sometimes conflicting information effectively.

• Good decision-making skills, with proven ability to make timely decisions that support laboratory operations.

• Commitment to compliance with FDA, CAP/CLIA, NYS, and Joint Commission regulations.

• Open-minded and flexible with updated workflows, process improvements, and operational changes.

• Eager to take on new opportunities and challenging assignments with urgency, high energy, and enthusiasm.

Additional Information

• Schedule: Tuesday through Saturday, 9:00 PM to 5:00 AM, 100% onsite.

• Location: Main Hospital Campus, 1275 York Avenue, New York, NY.

• Reporting to: IHC Assistant Manager.

Differential: 10% overnight differential & additional 10% differential for Sundays (20%!)

Helpful Links:

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Closing :

At MSK, we believe in fair, competitive pay that reflects your job, experience, and skills.

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.

Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.