Senior Product and Operations Manager (HYBRID: Chicago, NYC, RTP)

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. Location: [Chicago, IL; New York, NY; RTP, NC] This is a Hybrid role so you are required to be onsite 3 days a week About Tempus: Tempus is a technology company advancing precision medicine through the practical application of AI in healthcare. We have built one of the largest libraries of multimodal clinical and molecular data, and an operating system to make that data accessible and useful — helping physicians make real-time, data-driven decisions and accelerating the development of new therapies. The breadth and quality of our data is a core competitive advantage. Realizing that advantage depends on continually bringing new, high-value data sources onto our platform — from genomic and pathology labs to EHR-integrated provider networks, real-world data aggregators, and clinical content partners — and integrating them in a way that is scalable, compliant, and genuinely useful to downstream products. The Role: We're hiring a Senior Product Manager to own the data partnerships and integrations roadmap for the Tempus data platform. You will be the connective tissue between external data partners and our internal platform, clinical, and engineering teams — defining what data we bring on, how we ingest and normalize it, and how we turn it into a reliable, productized asset. This is a high-impact, cross-functional role for someone who is equally comfortable in a partner negotiation, a data model design review, and a roadmap prioritization discussion. You'll work across a diverse partner landscape spanning genetic and oncology testing labs, genomics and sequencing providers, EHR and provider data collaborations, FHIR-based health data platforms, real-world data, and clinical decision support content. What You'll Do: ● Own the data-source roadmap. Define and prioritize which new data sources and internal and external data partners to integrate, balancing strategic value, clinical utility, technical effort, and compliance risk. ● Lead cross-functional integration squads. Assemble and coordinate squads comprising Connectivity Engineers, Data Product Engineers, Domain SMEs to execute end-to-end data integrations – from intake through production launch and handoff to Operations. ● Partner with external data providers. Work alongside business development and legal to evaluate prospective partners, scope data-sharing arrangements, and translate partnership terms into concrete product and integration requirements. ● Drive integrations end to end. Lead the technical onboarding of new data sources — ingestion, mapping to common data models, normalization, quality validation, and ongoing monitoring — in partnership with engineering and data teams. ● Define data standards and contracts. Establish requirements for data formats, interoperability standards (e.g., FHIR, HL7), metadata, and provenance so each new source is consistent and trustworthy. ● Make data usable downstream. Ensure integrated data is discoverable and well documented for the clinical, product, and research teams who build on the platform; gather their requirements and feed them back into the roadmap. ● Measure what matters. Define success metrics for data coverage, completeness, freshness, quality, and adoption, and use them to drive continuous improvement. ● Navigate compliance by design. Partner with privacy, security, and regulatory teams to ensure every integration meets HIPAA and applicable data-governance, consent, and de identification requirements. What You'll Bring ● 5+ years in product management, with experience owning data, platform, or integration products (or comparable experience in data engineering, technical program management, or partnerships with a strong product orientation). ● Deep familiarity with healthcare data standards and interoperability (FHIR, HL7, OMOP, ICD/SNOMED/LOINC) and real-world data (RWD/RWE). ● A strong technical foundation: comfort with data models, APIs, ETL/ELT pipelines, and data quality concepts, and the ability to engage credibly with engineers on integration design. ● Experience working with external partners — translating ambiguous agreements into clear requirements and managing relationships across organizational boundaries. ● Demonstrated ability to prioritize ruthlessly and drive cross-functional execution across engineering, legal, business development, and clinical stakeholders. ● Excellent written and verbal communication; able to move fluidly between a partner conversation and a technical design discussion. Nice to Have: ● Experience in healthcare, life sciences, genomics, or clinical data. ● Working knowledge of HIPAA, data privacy, consent, and de-identification practices. ● Experience with cloud data platforms and modern data infrastructure. ● Hands-on with SQL or scripting for data exploration and validation. Why This Role Matters: Tempus' mission depends on the depth, breadth, and quality of its data. In this role you directly expand that foundation — every source you bring onto the platform makes our products smarter, our research more powerful, and our impact on patients more real. $120,000-$140,000 The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. Tempus was founded in August of 2015 by Eric Lefkofsky, after his wife was diagnosed with Breast Cancer. Shortly after he founded the company in an effort to bring the power of technology and artificial intelligence to cancer care, he convinced Ryan Fukushima to join as the company’s first employee. Ryan and Eric began assembling a world class team, focused on building the first version of a platform capable of ingesting real time healthcare data in an effort to personalize diagnostics. We built the platform for oncology and have expanded it to neuropsychiatry, cardiology, infectious disease (through COVID), and radiology. Despite our rapid growth, our mission remains the same—to help make sure patients are on the right drug at the right time, so they can live longer and healthier lives. We’re looking for people who can change the world. Who question the status quo and don’t shy away from tough problems. For the builders who are never done building and the learners who are never done learning. We’re looking for passionate people with undying curiosity. Those who want to attack one of the most challenging problems mankind has ever faced. Head on.