Senior/ Principal Scientist

Company Description Cime Therapeutics is a next-generation tech bio company that integrates synthetic chemistry, AI/ML, and automation to transform drug discovery. The organization has developed proprietary chemistry technology that enables faster, multi-step synthesis of complex molecules, providing a unique advantage in the industry. By combining multi-step synthesis and screening into a unified workflow, Cime accelerates the Design-Make-Test-Analyze cycle. Team members collaborate across scientific and technical disciplines to rapidly explore chemical space and advance therapeutic candidates.

Role Description The Senior/Principal Scientist will lead experimental design and execution to support Cime’s integrated synthesis and screening platform in an on-site, full-time role based in Boulder, CO. Responsibilities include planning and performing complex multi-step syntheses, optimizing reaction conditions, and analyzing results to inform iterative design of novel molecules. The scientist will align chemistry efforts with AI/ML-driven design and high-throughput screening strategies. Day-to-day activities involve generating and interpreting data, troubleshooting experiments, documenting methods and results, and presenting findings to internal stakeholders. This is a lab based position.

Qualifications

• Ph.D. in Chemistry with 0-4 years experience or equivalent industry experience; prior experience in pharma, biotech, or tech bio organizations is highly beneficial.
• Advanced expertise in synthetic organic chemistry and complex multi-step synthesis, with a strong track record of designing and executing challenging synthetic routes.
• Experience with analytical techniques such as NMR, LC/MS, HPLC, and chromatography for purification and characterization of small molecules.
• Background collaborating with or leveraging computational tools, AI/ML approaches, or automation platforms to support chemistry or drug discovery workflows.
• Demonstrated ability to design experiments, interpret data critically, troubleshoot issues, and iterate rapidly in a discovery setting.
• Strong scientific communication skills, including clear documentation of methods, preparation of reports, and presentation of results to diverse technical audiences.
• Proven experience working in cross-functional teams and mentoring or guiding junior scientists in a laboratory environment.
• Commitment to safety, quality, and reproducibility in laboratory operations, with the ability to thrive in a fast-paced, innovative environment.

Compensation & Benefits

Cime Therapeutics offers a competitive compensation package and the opportunity to make a meaningful impact at an early-stage biotechnology company.

• Base Salary: $100,000–$140,000 annually, depending on qualifications, experience, and demonstrated scientific expertise.
• Performance Bonus: Potential eligibility for a discretionary bonus based on individual and company performance. Bonuses are not guaranteed.
• Retirement: 401(k) retirement plan with a safe harbor employer contribution.
• Paid Holidays: Company-observed paid holidays.
• Paid Sick Leave: Paid sick leave in accordance with Colorado law.

The position will be leveled as Senior Scientist or Principal Scientist based on the candidate's experience, technical expertise, and demonstrated scientific leadership.

Interested candidates should submit a CV by emailing info at cimetherapeutics.com

Cime Therapeutics is committed to building a collaborative, innovative, and inclusive team. We welcome applications from scientists with diverse backgrounds and experiences who are passionate about advancing the future of chemistry and drug discovery.