Scientist - Protein and Biologics Screening Core (Host-Microbe Interactions)

Overview Join an excellent team of researchers dedicated to coming closer to the mission of St. Jude Children's Research Hospital, that no child will die at the dawn of life. The Protein and Biologics Screening Core within the Department of Host Microbe Interactions at St. Jude seeks a skilled and highly motivated candidate with experience in Antibody Discovery. This is a unique opportunity to join as an early member of the biologics core where we aim to discover therapeutic molecules to treat unmet pediatric diseases. Candidates with experience in Hybridoma fusion/B-cell culture are encouraged to apply. A PhD or equivalent is preferred with demonstrated post PhD experience in industry or academia. What you will do Design and execute antibody discovery campaigns from immunization to lead discovery. Utilize immunization, hybridoma/B-cell screening to drive binder discovery. Perform high throughput sorting to isolate specific B cell populations. Analyze and compare BCR sequences and immune repertoires. Serve as project leads for antibody discovery at St Jude. Strive for innovation and bring latest technologies to Biologics core. Maintain accurate and timely ELN data for discovery campaigns. Coordinate external discovery activities. Mentoring and help promote an inclusive work culture. Preferred skills Extensive knowledge of B-cell immunology and antibody development. The ability to design and execute in vivo studies to evaluate antibody efficacy. Demonstrated experience with single B-cell antibody discovery approaches. Prior experience with Beacon for mAb discovery would be a plus. Hands-on experience in B-cell sorting and screening through flow cytometry, ELISA and bio-layer interferometry Experience with antibody-related bioinformatic/software packages. Experience in NGS library preparation and BCR repertoire analysis. Experience in high-throughput cloning of antibody variable domains, antibody expression and characterization techniques (SPR, BLI, epitope binning). About St. Jude St. Jude Children's Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)-designated Comprehensive Cancer Center devoted solely to children. Our 300 faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine. St. Jude is ranked on Fortune Magazine's Best Workplaces in Health Care & Biopharma and Glassdoor's Best Places to Work. St. Jude is one of the best-funded research institutes in the US with an annual budget of over $2 billion per year. What We Will Offer You Working at St. Jude is a remarkable experience in many ways, and you will be provided with many special perks. Mission and Purpose: At St. Jude, working is more than just a job - it’s a calling. Each member is united by a shared purpose: finding cures and saving children. We offer a range of perks to enhance your experience. Community and Belonging: St. Jude is like a warm family that welcomes you, to a large part because it is a Children’s hospital. The Best of Both Worlds - Industry and Academia: Academic freedom in research and industrial efficiency and resources, with access to world-class shared resources/facilities led by expert scientists, coupled with state-of-the-art technology and funding. World-Class Benefits: Comprehensive benefits package. Enjoy healthcare, competitive salary, tuition assistance for continued education, and work-life balance with ample paid time off. Professional Growth: Opportunities to enhance scientific and soft skills; St. Jude has well defined career paths. Diversity: Inclusive and diverse scientific community; more information is available here. Competitive Compensation: Competitive salary (depending on experience), comprehensive benefits, and relocation assistance. In Memphis/Tennessee, there is no state income tax. Top Employer: St. Jude ranked among top employers in various lists with related links provided. Additional Perks: On-site gym, employee pharmacy, and other perks; more details on the St. Jude site. About Memphis St. Jude is located in the heart of Memphis, Tennessee, a vibrant city with music, culture, and history. Living in Memphis offers advantages including: Natural beauty and outdoor spaces such as the Mississippi River and Shelby Farms Park. Culture and heritage, including Elvis Presley’s birthplace. Affordability relative to other regions. Minimum Education and/or Training Bachelor\'s degree in relevant scientific area is required. Minimum Experience Eight (8) years of relevant work experience is required Six (6) years of relevant work experience is required with a Master\'s degree Three (3) years of relevant post-degree work experience is required with a PhD Compensation In recognition of state and municipal pay transparency laws, St. Jude provides a reasonable estimate of the compensation range. A reasonable estimate for this role is $86,320 - $154,960 per year, depending on experience, skill sets, training, and other factors. A specific offer will consider these factors. Explore our exceptional benefits! Equal Opportunity and Outreach St. Jude is an Equal Opportunity Employer. No search firms. See the official statements in the original posting for details about policy and processes. #J-18808-Ljbffr St Jude Children's Research Hospital