Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Principal Applied AI Engineer

$172.2k - $236.9k

Humana

Principal Applied AI Engineer

Become a key driver in shaping the future of AI-powered healthcare. We are looking for a Principal Applied AI Engineer, a technical leader who thrives in ambiguous, high-impact environments and is motivated by solving real problems with pragmatic, elegant, and scalable solutions. This position reports into the AI platform team, ensuring close alignment with platform strategy and delivery. It is for someone who wants autonomy, influence, and the responsibility of setting a high bar for engineering excellence.

What You'll Do

  • Lead the design and build of advanced generative AI systems, spanning LLM-powered applications, multi-agent workflows, RAG, and domain-specific reasoning engines.
  • Architect and own robust APIs and platform capabilities that bring AI to real business workflows at enterprise scale.
  • Drive the engineering of high-quality data, feature, and evaluation pipelines that support reliable and continuously improving AI behavior.
  • Partner with data scientists, platform engineers, and product leaders to transform conceptual ideas into resilient, testable, observable production systems.
  • Set engineering standards and elevate team culture, emphasizing clarity, craftsmanship, iteration, and objective measures of excellence.
  • Mentor other engineers and guide teams through complex technical decision-making.
  • Serve as a thought leader on the practical application of generative AI technologies, emerging patterns, and their fit within our ecosystem.
  • Champion observability, measurement, and operational excellence, ensuring deployed systems are trustworthy, maintainable, and high-performing.
  • Stay at the forefront of AI/ML advancements and help the organization understand the right time, and the right way, to adopt new technologies.
  • The successful candidate will help drive key business outcomes, including measurable improvements in healthcare delivery and member satisfaction.

Required Qualifications

  • Bachelor's or Master's in Computer Science, Engineering, or a related quantitative field.
  • 10+ years of professional software or platform engineering experience.
  • Deep expertise in Python, including building production services and shared libraries used by others.
  • Hands-on experience with modern AI systems, including LLM integration, RAG, embeddings, and applied generative AI patterns.
  • Strong background in machine learning engineering, including model deployment, monitoring, evaluation, and lifecycle management.
  • Expert-level understanding of FastAPI, Flask, or similar frameworks, and REST/gRPC service design.
  • Strong proficiency with cloud-native development on AWS, GCP, or Azure.
  • Minimum 5 years of containerization and orchestration experience (Docker, Kubernetes).
  • Production experience with CI/CD pipelines, version control, and modern DevOps practices.
  • Demonstrated ability to own large, ambiguous problems and deliver high-value, high-quality solutions.

Preferred Qualifications

  • Experience shaping engineering culture or influencing architectural direction across teams.
  • Experience with generative AI tooling (e.g., LangChain, LlamaIndex, PydanticAI, or similar).
  • Strong understanding of deep learning frameworks (PyTorch, TensorFlow).
  • Experience with distributed systems (Akka, Flink, or similar).
  • Prior work building platforms rather than one-off applications.
  • A track record of pragmatic decision-making, balancing innovation with maintainability and long-term value.

Additional Information

This position follows a hybrid work style and must be performed at one of our designated IT hub locations: Louisville, KY; Tampa, FL; Dallas, TX; Boston, MA; New York City; or Washington, D.C.

To ensure Home or Hybrid Home/Office employees' ability to work effectively, the self-provided internet service of Home or Hybrid Home/Office employees must meet the following criteria: At minimum, a download speed of 25 Mbps and an upload speed of 10 Mbps is required; wireless, wired cable or DSL connection is suggested. Satellite, cellular and microwave connection can be used only if approved by leadership. Employees who live and work from Home in the state of California, Illinois, Montana, or South Dakota will be provided a bi-weekly payment for their internet expense. Humana will provide Home or Hybrid Home/Office employees with telephone equipment appropriate to meet the business requirements for their position/job. Work from a dedicated space lacking ongoing interruptions to protect member PHI / HIPAA information.

Scheduled Weekly Hours

40

Pay Range

The compensation range below reflects a good faith estimate of starting base pay for full time (40 hours per week) employment at the time of posting. The pay range may be higher or lower based on geographic location and individual pay will vary based on demonstrated job related skills, knowledge, experience, education, certifications, etc. $172,200 - $236,900 per year. This job is eligible for a bonus incentive plan. This incentive opportunity is based upon company and/or individual performance.

Description of Benefits

Humana, Inc. and its affiliated subsidiaries (collectively, "Humana") offers competitive benefits that support whole-person well-being. Associate benefits are designed to encourage personal wellness and smart healthcare decisions for you and your family while also knowing your life extends outside of work. Among our benefits, Humana provides medical, dental and vision benefits, 401(k) retirement savings plan, time off (including paid time off, company and personal holidays, volunteer time off, paid parental and caregiver leave), short-term and long-term disability, life insurance and many other opportunities.

About Us

Humana Inc. (NYSE: HUM) is committed to putting health first – for our teammates, our customers and our company. Through our Humana insurance services and CenterWell healthcare services, we make it easier for the millions of people we serve to achieve their best health – delivering the care and service they need, when they need it. These efforts are leading to a better quality of life for people with Medicare, Medicaid, families, individuals, military service personnel, and communities at large.

Equal Opportunity Employer

It is the policy of Humana not to discriminate against any employee or applicant for employment because of race, color, religion, sex, sexual orientation, gender identity, national origin, age, marital status, genetic information, disability or protected veteran status. It is also the policy of Humana to take affirmative action, in compliance with Section 503 of the Rehabilitation Act and VEVRAA, to employ and to advance in employment individuals with disability or protected veteran status, and to base all employment decisions only on valid job requirements. This policy shall apply to all employment actions, including but not limited to recruitment, hiring, upgrading, promotion, transfer, demotion, layoff, recall, termination, rates of pay or other forms of compensation and selection for training, including apprenticeship, at all levels of employment.

Vacancy posted 1 day ago
Similar jobs that could be interesting for youBased on the Principal Applied AI Engineer in Boston, MA vacancy
  • $193.6k - $340.6k

     ...their customers and employees. Through Genesys Cloud, the AI-powered Experience Orchestration platform, organizations can...  ...and create the future of customer experience together. Principal Applied AI Engineer, Finance We are seeking a Principal Applied AI Engineer to... 
    Principal
    Work from home
    Worldwide
    Flexible hours

    Genesys Cloud Services, Inc.

    Boston, MA
    5 days ago
  • $185k - $230k

    A technology-driven company is seeking a Principal Full Stack Engineer to build an AI-powered platform that transforms the engineering services industry. This remote-first position offers a competitive salary between $185,000 and $230,000, alongside equity opportunities... 
    Principal
    Remote work

    Re:Build Manufacturing

    Boston, MA
    4 days ago
  •  ...Energy Jobline ZR seeks a Principal Engineer to join a team that builds, launches, and scales AI-companies in various sectors. Based in Boston but operating remotely, the position emphasizes full-stack product development, AI integration, and a collaborative work environment... 
    Principal
    Remote work

    Energy Jobline ZR

    Boston, MA
    5 days ago
  • A leading open-source software company is seeking a Principal Software Engineer to drive AI integration within their product portfolio. This role involves leading the design of scalable solutions, implementing Multi-Agent Systems, and collaborating with both internal teams... 
    Principal

    Red Hat

    Boston, MA
    4 days ago
  • $141.1k - $194k

     ...Senior Applied AI Engineer The Enterprise AI organization at Humana is a pioneering force, driving AI innovation across our Insurance and CenterWell business segments. By collaborating with world-leading experts, we are at the forefront of delivering cutting-edge AI... 
    Suggested
    Bi-weekly pay
    Work at office
    Work from home
    Home office

    Humana

    Boston, MA
    4 days ago
  • $73.8k - $218.8k

     ...We Are: Accenture's Oracle Business Group AI Center of Excellence is one of the most active enterprise AI innovation environments...  ...deep-dive and a client conversation. You might come from engineering, consulting, product, or pre-sales - what matters is that you build... 
    Work experience placement
    Live in
    Work at office
    Local area

    Accenture

    Boston, MA
    2 days ago
  •  ...Applied AI Engineer We are looking for an Applied AI Engineer to help us make Foley truly AI-native — not by layering tools on top, but by rethinking how work gets done across the company. You'll operate as a forward-deployed builder, embedded with business teams... 
    Remote work

    Foley

    Boston, MA
    1 day ago
  • $181.5k - $283.8k

     ...provide the therapy area teams key evidence for target evaluation and target discovery. We are seeking a highly specialized Applied AI Engineer Clinical Informatician to lead research at the intersection of completed clinical trial datasets and biobank-linked... 
    Full time
    For contractors
    Flexible hours

    Eli Lilly

    Boston, MA
    4 days ago
  •  ...About the job Applied AI Engineer About Us Catalyst Labs is a leading talent agency with a specialized vertical in Applied AI, Machine Learning, and Data Science. We stand out as an agency that's deeply embedded in our clients' recruitment operations. We... 
    Visa sponsorship
    Relocation package

    Catalyst Labs, LLC

    Boston, MA
    2 days ago
  •  ...Principal AI Agent Engineer Liberate builds AI agents to automate manual tasks for the $2.7T insurance industry. We started with voice — the hardest and most valuable channel in insurance — and are now expanding into full workflow automation across sales, servicing,... 
    Principal
    Work at office
    2 days per week

    Venturefizz Product Management Community

    Boston, MA
    2 days ago
  •  ...Job Title: Generative AI Engineer (Senior / Lead / Principal)- Multiple openings Experience Level: 8+ to 13+ Years Location: Hybrid - Remote (India-based) with onsite every Thursday in Chennai Industry: AI/ML, Enterprise Applications, Healthcare... 
    Principal
    Work at office
    Remote work

    Saviance

    Boston, MA
    5 days ago
  • $170k - $235k

     ...Principal Software Engineer, AI Engineering Cambridge, MA About this position: Context Labs is seeking a Principal Software Engineer...  ..., persistent problems. We understand that applying for a job can be intimidating. Applicants rarely meet every... 
    Principal

    Context Labs

    Cambridge, MA
    3 days ago
  • $172.2k - $236.9k

     ...Principal AI Engineer The Principal AI Engineer acts as Humana's senior technical authority for agentic AI platforms, overseeing strategy,...  ...AI systems, including LLM integration, RAG, embeddings, and applied generative AI patterns. ~ Strong background in machine learning... 
    Principal
    Bi-weekly pay
    Apprenticeship
    Work at office
    Work from home
    Home office

    Humana

    Boston, MA
    1 day ago
  •  ...About the job Applied AI / ML Engineer About Us Catalyst Labs is a leading talent agency with a specialized vertical in Applied AI, Machine Learning, and Data Science. We stand out as an agency thats deeply embedded in our clients recruitment operations.... 
    Full time
    Visa sponsorship

    Catalyst Labs, LLC

    Boston, MA
    3 days ago
  • $145.4k - $242.5k

     ...Job Description Summary As a Principal AI Software Engineer, you will drive technical vision and architect enterprise AI applications for multiple...  ...Relocation Assistance Provided: Yes For candidates applying to a U.S. based position, the pay range for this position... 
    Principal
    Contract work
    Work at office
    Relocation package

    GE Vernova

    Cambridge, MA
    5 days ago
  • $146k - $241k

     ...Position Overview The Principal Data/AI Engineer helps drive the technical strategy and architecture of enterprise-scale data and AI platforms that power mission-critical data products, analytics, and AI-driven solutions. In this role, you will operate as a technical... 
    Principal
    Remote work
    Work from home

    FUJIFILM Corporation

    Boston, MA
    5 days ago
  •  ...Pioneering in Cambridge, MA is seeking a Vice President of Engineering to lead a team of senior engineers in building AI-first solutions. This leadership role requires hands-on technical involvement, managing a team of Principal Software Engineers, and setting the architectural... 
    Principal

    Flagship Pioneering

    Cambridge, MA
    5 days ago
  • $179k - $199k

     ...one that is human-first and accelerated by AI to create meaningful and lasting change....  ..., working closely with other engineering teams across the organization to identify...  ...candidate screening and assessment. When you apply for a position, your information is processed... 
    Principal
    Work at office
    Remote work
    Flexible hours

    GrabJobs

    Boston, MA
    4 days ago
  • $99.6k - $223.4k

     ...future of healthcare - cloud-native Healthcare Solutions with AI at their core, designed to operate at nation-scale. Our mission...  ...administrative burden. We’re looking for highly skilled AI engineers to design and build high-scale, cloud-based data processing... 
    Principal
    Temporary work
    Flexible hours

    Oracle

    Boston, MA
    5 days ago
  • $188k - $282k

     ...individual with a passion for data and AI technology who can help our team drive...  ...adoption at scale. As a Senior Principal AI Engineer in the Data Platforms team, you will unlock...  ...position for which the applicant has applied should make a request to the recruiter... 
    Principal
    Summer work

    Vertex Pharmaceuticals

    Boston, MA
    5 days ago
  • Autodesk, Inc. is seeking a Research Engineer in Boston to reshape the future of manufacturing through experimentation in AI and digital transformation. This role includes designing experiments, developing workflows, and collaborating with industry partners. The ideal candidate... 

    Autodesk, Inc.

    Boston, MA
    3 days ago
  •  ...fastest and most powerful way for design professionals to search, sample, and specify materials. About the role As an Applied AI Engineer, you will drive the design, build, and deployment of next-generation AI-powered experiences across Material Bank's platform.... 
    Temporary work
    Local area
    Remote work
    Flexible hours

    Material Bank

    Boston, MA
    15 days ago
  • $225k - $275k

     ...that defines Acadian. Position Overview: The Principal AI Engineer is a senior technical leader responsible for defining, designing...  ...health, retirement, and wellness offerings. To apply for this position or view Acadian’s open roles, please visit... 
    Principal
    Full time
    Casual work
    Work at office
    Worldwide
    Flexible hours
    3 days per week

    Acadian Asset Management

    Boston, MA
    2 hours ago
  • A leading technology company in Cambridge, MA, is seeking an AI/ML Engineer to develop systems that turn scientific execution data into actionable insights. The ideal candidate must possess strong programming skills and machine learning fundamentals, collaborating closely... 

    Transfyr Bio

    Cambridge, MA
    2 days ago
  • $96.8k - $251.6k

     ...Job Description The Senior Principal AI Agent / ML Software Engineer is a Senior Staff-level, hands-on technical leadership role responsible for defining, building, and operating next-generation AI systems on Oracle Cloud Infrastructure (OCI). This person will set... 
    Principal
    Temporary work
    Flexible hours

    Oracle

    Boston, MA
    2 days ago
  •  ...systems for advanced materials synthesis enabling dynamic process control and breakthroughs in new materials. We are seeking an Applied AI/ML Engineer to support the development, deployment, and scaling of models for materials processing and characterization data. Your work... 

    Atomscale

    Boston, MA
    1 day ago
  • $174.4k - $218k

     ...Role Overview The Enterprise AI Platform Engineer is responsible for build and delivery of Natera’s enterprise agentic AI platform. The enterprise...  ...of engineering excellence, low code platform design, and applied GenAI engineering. You will architect and build the core AI... 
    Principal
    Work at office
    Immediate start
    Remote work
    Worldwide

    GrabJobs

    Boston, MA
    3 days ago
  • $170k - $200k

    Principal AI Engineering ArchitectSkip to main content# Careers at TMGPrincipal AI Engineering Architect page is loaded## Principal AI Engineering ArchitectApplyremote type: In Office, Hybrid, or Remotelocations: Iowa - TMG Home Office: Dallas, Texas: Chicago, Illinois... 
    Principal
    Full time
    Temporary work
    Work at office
    Remote work
    Home office
    Flexible hours

    The Mutual Group

    Boston, MA
    2 days ago
  • Physical Superintelligence in Boston is seeking engineers to develop platform infrastructure combining AI and computational science. The role focuses on applying machine learning to real-world physics challenges, requiring five or more years of production experience, strong... 

    Physical Superintelligence

    Boston, MA
    4 days ago
  • $127k - $167k

     ...We are seeking an AI Engineer to join our Managed Services team. You will design, integrate, and deploy AI solutions-including agentic...  ...role is ideal for a strong software engineer passionate about applying AI to real-world challenges, collaborating with cross-functional... 
    Temporary work
    Worldwide

    InterSystems

    Boston, MA
    5 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Principal Applied AI Engineer. Be the first to apply!