Senior Director Pharmacology

Are you an experienced oncology drug development leader with a track record of advancing therapies from discovery through regulatory approval? We're partnering with an innovative biotechnology organization seeking a Senior Director, Oncology Pharmacology to provide scientific leadership across a diverse oncology portfolio. This individual will play a critical role in shaping nonclinical development strategy, driving pharmacology plans, and supporting programs from discovery through IND-enabling development and beyond. Key Responsibilities Lead nonclinical pharmacology strategy across multiple oncology programs. Design and oversee studies evaluating efficacy, pharmacodynamics, mechanism of action, and biomarker strategies. Drive translational approaches that support candidate selection, indication expansion, and clinical development decisions. Collaborate closely with Toxicology, DMPK, Clinical Pharmacology, Biomarkers, Regulatory Affairs, and Clinical Development teams. Manage external CRO and academic partnerships. Contribute to regulatory submissions, including INDs, NDAs, and BLAs. Mentor and develop scientific talent while serving as a key leader within a highly matrixed R&D environment. Background We're Looking For PhD in Pharmacology, Immunology, Biology, Biochemistry, Cancer Biology, or a related scientific discipline. 10+ years of industry experience in nonclinical oncology pharmacology . Demonstrated success advancing oncology assets from discovery through IND-enabling development. Experience supporting at least one approved therapeutic product and/or major regulatory submission. Deep understanding of oncology drug development, including solid tumors, hematologic malignancies, and/or immuno-oncology. Experience across multiple therapeutic modalities, including biologics and other advanced treatment platforms. Proven scientific leadership in cross-functional drug development teams. Prior people leadership experience. Preferred Experience Oncology efficacy model development and execution. Immuno-oncology research. Biomarker identification and translational strategy. Mechanism-of-action studies. CRO management and outsourced pharmacology programs. Experience with biologics, ADCs, bispecifics, cell therapies, or other emerging oncology modalities. Important Note This role is focused on nonclinical/preclinical oncology pharmacology leadership . Candidates whose experience is primarily in Clinical Pharmacology, Pharmacometrics, Population PK, PK/PD Modeling, or Quantitative Clinical Pharmacology without significant ownership of oncology pharmacology programs are unlikely to be a strong fit. Why Apply? Fully remote within the United States. Opportunity to influence high-impact oncology programs. Visible leadership role with broad cross-functional exposure. Work across multiple therapeutic modalities and cutting-edge oncology science. Interested in learning more? Apply directly or reach out for a confidential discussion.