Senior Director, Health Economics and Outcomes Research / Real World Evidence

Job Summary IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small‑molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first‑in‑class targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody‑drug conjugates (ADCs) for molecularly defined solid‑tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. Location South San Francisco, CA. Position Summary We are seeking a Senior Director of Health Economics and Outcomes Research / Real World Evidence (HEOR/RWE) to join the IDEAYA Commercial team. The Senior Director, HEOR/RWE will shape and execute IDEAYA’s health economics, outcomes research, and real‑world evidence strategy for the launch of darovasertib in metastatic uveal melanoma (mUM). This leader will play a pivotal role in generating evidence in a very high unmet disease area for payers, providers, and patients, and will take innovative approaches to value demonstration in orphan diseases, biomarker‑driven populations, and unique combination treatments. While the initial focus will be on darovasertib, this role will evolve over time to include direct reports and contribute on the global launches of IDEAYA’s exciting pipeline of oncology assets. The position is based in our South San Francisco headquarters and requires onsite presence four days per week. Responsibilities Develop and execute the HEOR and RWE strategy to support US value demonstration for darovasertib at launch and through its lifecycle. Collaborate with Market Access, Medical Affairs and Clinical Development to evaluate data gaps and develop robust evidence generation and publication plans. Develop and execute core evidence‑generation activities including chart reviews, literature reviews, PRO studies, and micro‑costing analyses to strengthen the clinical and economic differentiation of the product. Design and implement real‑world data analyses to articulate the current patient demographics, treatment patterns, and outcomes for mUM patients. Develop comprehensive health economic model analyses to demonstrate value, inform pricing strategy, and support reimbursement decisions. Partner with Market Access to develop robust and compelling clinical, humanistic, and economic value propositions and oversee development of AMCP and Global Value Dossiers. Lead the external dissemination of HEOR/RWE deliverables including publications, presentations, and professional conferences. Develop, train, and implement the resources that support field HEOR efforts with key customers; ensure programs and materials comply with SOPs and Medical, Legal & Regulatory (MLR) reviews. Engage and collaborate with external partners including payers, providers, and other access decision‑makers to establish and maintain strong partnerships and gather insights. Support field team engagements during Preapproval Information Exchange (PIE) and post‑approval interactions to educate payers and provider access stakeholders on darovasertib. Stay current with advancements in methodologies and best practices; closely monitor new trends in health policy and payer environment and integrate into cross‑functional strategies. Influence the design of IDEAYA’s clinical development programs through global price and market access and commercial opportunity assessments. Oversee budgeting and financial planning for all HEOR/RWE activities. Requirements Advanced, doctoral level degree in a related discipline with at least 10–15 years of related experience. Experience in the biotech/pharmaceutical industry in US HEOR/RWE and with market access strategies. Experience with rare disease and oral drugs is strongly preferred. Demonstrated success with US commercialization and launches. Deep technical knowledge and experience with clinical and HEOR/RWE data sets, methodologies, analyses, and processes to optimize execution of value evidence tactics. Experience developing US and global value evidence generation plans for pipeline assets. Experience establishing relationships with clinical and HEOR experts. Experience interacting with US access decision‑makers. Excellent communication and presentation skills, ability to present to diverse stakeholders including external partners, healthcare professionals and senior leaders. Excellent organizational, project management and problem‑solving skills. Ability to thrive in a fast‑evolving environment. In‑office role (four days per week) with 15% estimated travel to vendor partners and relevant conferences/meetings as deemed necessary. Total Rewards IDEAYA offers a comprehensive benefits package that reflects our pay‑for‑performance philosophy, including medical/dental/vision coverage (100% company‑paid for employees and 90% for dependents), 401(k), ESPP, wellness programs, and a competitive total rewards package featuring merit‑based salary increases, discretionary short‑term incentive plan participation, and stock‑option awards (subject to board approval). Compensation The expected salary range for the Senior Director, Health Economics and Outcomes Research / Real World Evidence role is $282,000–$349,000. The final salary offered to a successful candidate will depend on various factors, including location, experience, educational background, and performance during the interview process. Code of Conduct All employees are expected to act with integrity and in full compliance with applicable laws, regulations, and IDEAYA policies, including IDEAYA’s Code of Conduct. Employees must demonstrate good judgment and ethical behavior in all business activities, maintain patient and product safety as a top priority, and report any suspected violations of law or company policy through appropriate channels. Equal Opportunity Employment IDEAYA is an equal opportunity employer. In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets. The Company complies with all laws respecting equal employment opportunities and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. Vaccination Requirement This position requires you to be fully vaccinated from COVID‑19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. You are considered fully vaccinated once 14 days have passed since receiving either the second dose in a two‑dose COVID‑19 vaccine series or a single‑dose COVID‑19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization. Reasonable Accommodations We are committed to providing reasonable accommodations to qualified individuals with disabilities. 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