Associate Director, Clinical Scientist

Overview Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction‑associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once‑daily, oral, liver‑directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high‑performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. Key Responsibilities Contribute to the design and development of clinical trial protocols, including scientific rationale, study objectives, endpoints, and eligibility criteria. Author or review key clinical documents such as investigator brochures, informed consent forms, clinical study reports (CSRs), and regulatory submissions. Provide scientific input during trial execution, including protocol amendments, site engagement, data reviews, and ongoing study support. Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure high‑quality trial conduct and data integrity. Conduct data reviews and support data interpretation in collaboration with biostatistics and the medical team. Support the preparation of documents for regulatory submissions, health authority meetings, and internal governance presentations. Stay current on therapeutic area trends, competitive landscape, and regulatory guidance related to MASH/NASH and associated comorbidities. Participate in cross‑functional meetings and contribute to development strategies and timelines. Experience and Professional Qualifications Advanced degree (PhD, MD, PharmD, or equivalent) in a life sciences field required; Master’s with relevant experience may be considered. 2+ years of experience in clinical development or clinical research within the pharmaceutical or biotechnology industry. 10+ years relevant experience. Prior experience in liver disease, metabolic disorders, or MASH/NASH strongly preferred. Solid knowledge of ICH/GCP and global clinical trial regulations. Demonstrated ability to synthesize complex scientific data and present it clearly and effectively. Excellent verbal and written communication skills. Collaborative mindset with strong organizational and project management abilities. Preferred Attributes Experience working in a fast‑paced biotech environment with small, agile teams. Familiarity with liver disease endpoints such as histology, imaging, or non‑invasive biomarkers. Experience supporting regulatory interactions or submissions is a plus. Total Rewards Base salary is $175,500 – $214,500 per year, with equity and bonus opportunities. All full‑time employees receive equity, reinforcing an ownership culture. Equity offers meaningful opportunity to share in the success employees help create. Benefits Comprehensive benefits including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings. Additional voluntary benefits such as supplemental life insurance, legal services and other offerings are available. Mental health benefits are provided through an Employee Assistance Program for employees and their families. Other benefits are provided in accordance with applicable federal, state, and local laws. EEO Statement Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. #J-18808-Ljbffr