Principal Enterprise Architect

Job Description

Job Title: Principal Enterprise Architect

Department: Technology . Office of CTO | Technology & Execution | Enterprise Architecture team

Reports To: Sr. Director, Enterprise Architecture

Job Summary: The Enterprise Architect will help shape and implement Myriad Genetics' next-generation technology stack, aligning architecture decisions with business growth, operational scale, and life sciences priorities. This role requires a pragmatic architecture leader who has successfully delivered modern enterprise platforms in healthcare, diagnostics, biotech, or life sciences environments.

This is a hands-on enterprise architecture role focused on translating business strategy into executable architecture across life sciences capabilities, including digital engagement, provider and patient experiences, data governance, integration, identity, automation, analytics, and AI-enabled workflows. The Enterprise Architect will partner with business, product, engineering, security, data, and operations teams to define target-state architecture, evaluate platform options, guide implementation, and prepare clear executive recommendations.

The ideal candidate has implemented modern platform capabilities such as integration platforms as a service (iPaaS), master data management (MDM), digital experience platforms (DXP), identity and access management (IAM), cloud, data platforms, intelligent document processing, and applied AI - not just evaluated them.

Responsibilities:

• Enterprise Architecture Strategy: Define architecture strategies, principles, standards, and roadmaps that connect Myriad's life sciences business priorities to scalable technology execution.
• Architecture Design & Governance: Design, review, and guide business, application, data, integration, security, and technology architectures across enterprise initiatives, ensuring alignment to platform strategy and long-term reuse.
• Technology Evaluation & Decision Support: Lead buy vs. build vs. hybrid evaluations for strategic capabilities, balancing business fit, technical fit, cost, risk, scalability, compliance, and speed to value.
• Next-Gen Platform Implementation: Provide architecture leadership for implementation of iPaaS, MDM, DXP, IAM, API management, cloud, data platforms, automation, intelligent document processing, and AI-enabled capabilities.
• Discovery & Stakeholder Alignment: Facilitate discovery, capability assessments, current-state/future-state mapping, and decision alignment across business, product, engineering, security, data, and operations teams.
• Executive Communication: Prepare concise recommendations, roadmaps, trade-off analyses, and decision summaries for senior leadership and governance forums.
• Business Case & Value Realization: Partner with business and finance teams on investment justification, total cost of ownership, ROI modeling, and measurable business outcomes.
• Delivery Partnership: Work closely with product, program, engineering, and vendor teams to keep implementation aligned to architecture intent, business outcomes, quality, timelines, and constraints.
• Modernization & Reuse: Identify opportunities to simplify, consolidate, modernize, and reuse technology capabilities across the enterprise.
• Risk, Security & Compliance: Identify technical, security, compliance, data, and operational risks and recommend practical mitigation strategies.
• Architecture Artifacts: Create practical artifacts such as capability maps, target-state diagrams, integration patterns, reference architectures, decision records, and roadmaps.
• Standards & Best Practices: Promote architecture standards, patterns, and practices that enable secure, consistent, and effective use of enterprise platforms.

Qualifications:

• Education : Bachelor's degree in Computer Science, Information Systems, or a related field; Master's degree preferred.
• Experience : Minimum of 10 years in IT architecture, including 5+ years in healthcare, diagnostics, biotech, or life sciences, with demonstrated experience implementing modern enterprise platforms.
• Skills : Strong architecture, analysis, communication, and stakeholder alignment skills; practical experience with enterprise architecture frameworks such as TOGAF; exposure to cloud, APIs, data platforms, Salesforce, Oracle, laboratory systems, portals, and SaaS ecosystems.
• Life Sciences Knowledge : Strong understanding of healthcare, diagnostics, biotech, or life sciences operating models, including regulatory, privacy, data, and interoperability considerations such as HIPAA, PHI, and FHIR.
• Technologies : Hands-on implementation exposure to iPaaS, MDM, DXP, IAM, API management, cloud, data platforms, intelligent document processing, AI-enabled workflows, and related integration and automation patterns.

Preferred Attributes:

• Delivery Leadership : Proven ability to guide complex, cross-functional technology initiatives from strategy through implementation.
• Innovation : Ability to apply emerging technologies pragmatically to improve business outcomes, user experience, and operational efficiency.
• Adaptability : Comfortable operating in a fast-changing environment with evolving priorities, platforms, and delivery models.
• Business Process Acumen : Understanding of procurement, legal, security, finance, and vendor management processes needed to move strategic technology decisions forward.
• Cross-Functional Partnership : Ability to align business, technology, security, finance, and vendor stakeholders around clear decisions and executable plans.

About the Team:

• You will be working with the Office of the CTO within Myriad Genetics' Enterprise Architecture team
• Our team partners across business and technology functions to shape enterprise strategy, guide major platform decisions, and deliver scalable digital transformation.
• We are focused on life sciences innovation, modern platform enablement, and architecture practices that improve provider, patient, commercial, operational, and data capabilities.

Required

• U.S. citizen or national
• Green Card holder
• Living full time in the USA

We take geographic location into account when determining base salary to ensure equitable and competitive compensation.

#LI-KO1

About Us

Ready to transform the future of patient care through the power of genetics?

For more than 30 years, Myriad Genetics has led the way in precision medicine by delivering important insights to help people make informed health decisions. As a leading molecular diagnostic testing and precision medicine company, we are dedicated to advancing health and well-being for all. Our innovative genetic tests are used across specialties including oncology, women's health, and mental health, empowering clinicians to personalize treatment and help their patients take proactive steps toward better outcomes.

What inspires us - and you - is simple: Every test, every insight, and every patient story emphasizes our commitment to improving lives through science, innovation, and care. you're ready to help shape the future of medicine. Your work will have meaningful impact, and your dedication can change lives. Learn more at and follow Myriad Genetics on LinkedIn.

We are an equal opportunity employer and place high value on inclusion and belonging. We prohibit discrimination and harassment on the basis of any protected characteristic, including race, religion, color, national origin, gender, sexual orientation, gender identity, gender expression, age, marital or veteran status, pregnancy or disability, or any other basis protected under applicable law. In accordance with applicable law, we make reasonable accommodations for applicants' and employees' religious practices and beliefs, as well as any mental health or physical disability needs. If you need assistance submitting your application due to a disability, you can request an accommodation by contacting View email address on click.appcast.io.

Please answer all questions completely. Please do not provide any information not specifically requested on this Employment Application form. To get the best candidate experience, please consider applying for a maximum of 3 roles within 12 months to ensure you are not duplicating efforts.


Myriad Genetics will never request payment, solicit personal financial information, or conduct interviews via informal channels (e.g., personal email, text messages). All opportunity-related communication with Myriad Genetics will come from our employees, whose e-mail addresses end with "@myriad.com."