Scientist II or Senior Scientist, Discovery Proteomics

How you’ll make an impact Working closely with program teams towards addressing key biology and chemistry questions Develop and optimize sample preparation and mass spectrometry methods for deep quantitative analysis of cell and tissue total proteomes as well as post‑translational modifications. Perform maintenance, quality control and troubleshooting of instruments, including HPLCs and mass spectrometers Establish robust nLC‑MS‑based data acquisition and analysis workflows Provide documentation, analysis, interpretation and presentation of experimental data in a clear and concise manner Present scientific results and strategic recommendations to internal project teams, senior leadership, and external collaborators in a clear, concise, and influential manner. Stay up to date on proteomics methods and technologies Proactively recognize and solve technical and scientific issues to ensure high quality proteomics data is generated for the progression of drug discovery projects. Skills and experience you’ll bring PhD in Biochemistry, Biology, Chemical Biology, or a related discipline, with 3+ years of quantitative mass spectrometry‑based proteomics experience, or 7+ years of industry experience in proteomics. Extensive hands‑on experience in proteomics is required including: Demonstrated ability to independently troubleshoot, analyze, and interpret proteomics data with attention to detail, to recommend and execute next steps. High level of proficiency in a variety of quantitative proteomics techniques including DIA, label‑free quantification and peptide fragmentation methods. Maintaining and troubleshooting HPLCs and mass spectrometers. Developing methods and performing nano LC‑MS/MS experiments using Orbitrap Astral or Orbitrap Exploris 480 mass spectrometers. Experience in computational analysis and downstream statistical analysis software packages, such as DIANN, Perseus, R or Python, to address key program questions. Ability to work in an agile, fast‑paced, team‑oriented environment. Lead from the lab for activities include hit validation, lead optimization, target validation, and small molecule mechanism of action studies. Experience with PTM analysis (phosphorylation and ubiquitination), protein interaction analysis, and targeted proteomics are a plus. Experience in low abundance protein isolation from complex biological samples including cells, tissue and biofluids and affinity enrichment to selectively enrich sub‑proteomes and experience with automation and liquid handling systems are a plus. Experience in mapping protein‑protein interactions by mass spectrometry with pulldown approaches, proximity labeling and XL‑MS are a plus. Tissue culture experience with suspension and adherent cell lines is a plus. Compensation Kymera offers a competitive compensation package that recognizes both results and capabilities through market‑based, performance‑driven pay. The anticipated base salary range for this role is $90,000 – $200,000, with eligibility for annual bonus, equity participation, and comprehensive benefits. Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position. Equal Employment Opportunity Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class. #J-18808-Ljbffr Kymera Therapeutics