Executive Director, Clinical Supply Chain

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Executive Director, Clinical Supply Chain provides strategic leadership and operational oversight for end-to-end clinical supply chain activities across the organization. Strategic Leadership * Define and execute the global clinical supply chain strategy aligned with the company’s clinical development pipeline and long-term business goals. * Establishes strategies and processes to ensure uninterrupted supply for Revolution Medicines portfolio across all phases of development. * Lead and serve as subject matter expert for clinical supply chain planning, risk management, and execution of clinical supply chain activities. * Build scalable processes and infrastructure to support early- through late-phase clinical programs. * Strategic Planning on comparator sourcing management to ensure timely, compliant and cost-effective product availability. * Effective management of clinical studies executed in conjunction with collaboration partners. * Identify and implement overall clinical supply chain best practices. Clinical Supply Operations * Oversee end-to-end clinical supply activities, including demand forecasting, protocol reviews, packaging, labeling, distribution, and returns. * Ensure uninterrupted supply of investigational medicinal products (IMP), including RevMed and comparator products. * Champions monthly Development Operations planning (DnOP) process in collaboration with PDM and Clinical Operation team members. * Ensures efficient global clinical supply chain distribution networks are in place. * Oversee comparator products demand and supply planning with expert level knowledge in comparator drugs and co-medications sourcing strategy Cross-Functional Collaboration * Partner with Clinical Operations and Clinical Study Execution Teams (CSET) in study planning and execution. * Collaborate with PDM, Quality, and Regulatory to ensure compliant manufacturing, labeling, and distribution

• Work closely with Finance on budgeting, forecasting, and cost optimization.
• Work effectively with internal and external partners to develop sound

strategies, identify and mitigate risks, and resolve issues as they arise. Compliance & Quality * Ensure all clinical supply activities comply with GxP, ICH, FDA, EMA, and global regulatory requirements. * Expert knowledge of applicable GxP requirements and applicable regulatory guidances. * Lead inspection readiness activities as required for global filings and maintain and inspection ready organization. Team Leadership * Build, lead, and mentor a high-performing clinical supply chain organization. Drives for excellence in execution of agreed upon strategies. * Establish clear performance metrics, development plans, and succession planning. * Foster a culture of accountability, continuous improvement, and collaboration. * Drives excellence in setting clear and actionable team goals. Required Skills, Experience and Education: * Bachelor’s degree in Supply Chain, Business, Engineering or Life Sciences with 20+ years of experience in pharmaceutical supply chain. Master’s degree (MS, MBA) with at least 18 years of experience in pharmaceutical/biotech supply chain.

• CPIM/CSCP certifications a plus.
• At least 5 years of experience in a leadership/supervisory role.
• Strong knowledge and experience with cGMP operations for small molecules,

end- to end supply chain and demand/supply planning.

• Effective vendor management and oversight skills
• Excellent cross-functional leadership skills with effective communication

skills. Preferred Skills:

• Proven leadership experience hiring, managing and developing teams.
• Knowledge and experience with outsourced manufacturing operations. (CMO’s)
• Effective, open and transparent communication skills (verbal and written).

Strong analytical, communication and executive level reporting skills.

• Capable of working on multiple projects/tasks and able to meet timelines.
• Self-starter with a high-level of comfort with ambiguity and complexity and

the ability to multi-task while consistently delivering quality results. * Team-oriented, progressive thinker who enjoys participating in an innovative and creative work environment. #LI-Hybrid #LI-GL1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice

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contact View email address on click.appcast.io [View email address on click.appcast.io]. Base Pay Salary Range

$265,000—$331,000 USD

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