Quality Management System Lead

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts. Summary Own and continuously improve the QMS framework to ensure processes, document control, training, and quality records support consistent compliance across functions and regions. Your Role: Define and maintain QMS structure: policies, SOPs, work instructions, templates, and governance Ensure harmonization across GxP domains (GMP/GLP/GCP) and alignment with applicable regulations/standards Oversee document lifecycle management (authoring standards, review/approval, periodic review, archival) Ensure change control processes exist and are followed (QMS changes and cross-functional change impacts) Oversee GxP training framework (curricula, assignment rules, effectiveness checks, compliance reporting) Partner with functional owners to define role-based training requirements Ensure QMS records are complete, traceable, audit-ready, and meet data integrity principles Establish metrics and trending for QMS health (cycle time, overdue items, training compliance) Lead QMS simplification/optimization, including CAPA prevention initiatives based on trending and learnings Prepare Quality Management Review packages: KPIs, risks, audit outcomes, CAPA effectiveness, and improvement plans What You Bring: Bachelor’s degree in Life Sciences, Quality, or related discipline (required) Quality-related certification preferred (e.g., ASQ, ISO Lead Auditor, Quality Systems) Training in electronic QMS platformsadvantageous 8–12 years in Quality Assurance or Compliance Hands‑on experience managing QMS in regulated GxP environments Experience supporting QMS‑related inspections and audits QMS design, lifecycle management, and governance GxP training systems and compliance tracking Data integrity and document control standards Process‑oriented, structured, and detail focused Strong communication and training skills Ability to simplify complex processes and drive alignment We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. Salary range

$151,200 - $226,800 USD

Are you currently located in the Greater Boston area and able to commute to 201 Brookline Avenue, near Fenway Park, on a flexible/hybrid schedule? Will you require employment sponsorship now or in the future? Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file. As set forth in Tango Therapeutics’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law. Voluntary Self-Identification of Disability Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 04/30/2026 We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years. Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at . A disability is a condition that substantially limits one or more of your "major life activities." If you have or have ever had such a condition, you are a person with a disability. How do you know if you have a disability? Alcohol or other substance use disorder (not currently using drugs illegally) Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS Blind or low vision Cancer (past or present) Cardiovascular or heart disease Celiac disease Cerebral palsy Deaf or serious difficulty hearing Diabetes Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders Epilepsy or other seizure disorder Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome Intellectual or developmental disability Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD Missing limbs or partially missing limbsMissing limbs or partially missing limbs Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS) Neurodivergence, for example, attention‑deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities Partial or complete paralysis (any cause) Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema Short stature (dwarfism) Traumatic brain injury PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete. #J-18808-Ljbffr Tango Therapeutics