Principal Scientist, Immunology

Job Description

Job Description

About Tonix*

Tonix is a fully integrated biotechnology company, publicly traded on NASDAQ (ticker: TNXP), with marketed products and a pipeline of development candidates The Company is focused on commercializing, developing, discovering, and licensing therapeutics to treat and prevent human disease. In August 2025, Tonix received FDA approval for Tonmya™ (cyclobenzaprine HCl sublingual tablets), a first-in-class, once-daily, non-opioid treatment for fibromyalgia. Tonmya is the first new fibromyalgia therapy approved in over 15 years, following successful Phase 3 trials demonstrating significant symptom improvement. Commercial launch is expected in the fourth quarter of 2025. Tonix also markets Zembrace® SymTouch® (sumatriptan injection) 3 mg and Tosymra® (sumatriptan nasal spray) 10 mg, both indicated for the treatment of acute migraine with or without aura in adults.

Tonix’s development portfolio includes product candidates in central nervous system (CNS), immunology, immuno-oncology infectious disease and rare disease. The CNS pipeline features both small molecules and biologics to treat pain, neurologic, psychiatric, and addiction conditions. The immunology portfolio includes biologics to address organ transplant rejection, autoimmunity, and cancer. The infectious disease pipeline includes a vaccine in development to prevent smallpox and monkeypox, which also serves as a live virus vaccine platform for other infectious diseases. Finally, the rare disease portfolio includes a product in development for Prader-Willi syndrome, which has both orphan drug designation and rare pediatric disease designation grants from the FDA.

Tonix owns and operates a state-of-the art infectious disease research facility in Frederick, Md.

Please visit for specifics on the pipeline.

*All of Tonix’s product candidates are investigational new drugs or biologics and have not been approved for any indication.

Position Overview

Tonix is seeking a highly motivated and innovative Principal Scientist with a background in immunology, autoimmunity or oncology to contribute to research and development across our growing immunology portfolio. This is an excellent opportunity to directly participate and obtain exposure to the end-to-end product development process including early-stage therapeutic discovery, nonclinical safety and pharmacological evaluation, cGMP manufacturing and clinical evaluation. The candidate will have a Ph.D. or M.D./Ph.D. in a relevant field, a strong publication record, and experience working in an interdisciplinary team environment. The position is located at the Tonix Research and Development Center (RDC) which is the innovation and development arm of Tonix Pharmaceuticals. The RDC houses state-of-the-art equipment (i.e., high content imaging, mass spectrometry, spectral flow cytometry, multi-parallel bioreactors, etc.) and is responsible for development of efficient and cutting-edge treatment methods for various diseases including infectious diseases, oncology, and other indications. This position will require an in-depth knowledge of in-vivo immunology and/or virology; will involve organizing and implementing complex research plans, developing methods of testing, data collection and analysis; and will involve writing reports containing descriptive, analytical, and evaluative content. The duties will also require the exercise of independent discretion and judgment in carrying out research activities within the predetermined research scope. Experience in the composition of scientific publications, research program technical reports, and research grants is required.

Key Responsibilities

• Establish and maintain a robust flow cytometry pipeline to support in-depth immunology research.
• Conduct independent and original research supporting the Tonix portfolio and RDC mission
• Develop novel methods and assays to contribute to the RDC research pipeline
• Establish in-vitro and in-vivo models to support evaluation of immunotherapeutics against diverse disease conditions (e.g., autoimmunity, oncology)
• Collection, analysis, and evaluation of data
• Interpret data, make decisions, and conduct troubleshooting on related technical issues
• Preparation of scientific presentations, reports, manuscripts, and grant proposals

This is a fast-paced challenging position offering competitive compensation and benefits package. This position will report to the Director of Immunology and will be based at the Tonix Research and Development Center in Frederick, Maryland.

Essential Duties & Responsibilities

• Design, optimize, and standardize novel in-house flow cytometry assays, ensuring consistent reliability and reproducibility of screening outcomes.
• Establish multi-parameter flow cytometry panels using spectra flow cytometry and define data acquisition and analysis pipelines to support RDC programs
• Provide scientific leadership and expertise in cell-based, molecular, and biochemical assays, while ensuring rigorous experimental data analysis.
• Independently troubleshoot, problem-solve, and execute experiments, while effectively incorporating feedback and adapting to evolving project needs.
• Work cross-functionally in a matrix environment, partnering with project and functional teams to drive research objectives forward.
• Characterize and assess binding properties of novel proteins and antibodies using cutting-edge technologies, including Octet, high-content plate-based imaging, and novel reporter-based assays.
• Lead and participate in cross-functional project teams, proposing innovative discoveries and optimization strategies that align with industry’s best practices.
• Integrate cross-functional inputs to develop a robust, strategic R&D plan, ensuring alignment with Tonix’s innovation goals.
• Uphold company mission and values, emphasizing accountability, innovation, integrity, quality, and teamwork.
• Support special projects and business initiatives as needed to contribute to Tonix's broader corporate strategy.

Minimum Qualifications

• Ph.D., or equivalent doctoral degree
• Strong accomplishment record demonstrating the ability to perform independent, high-quality, creative, and impactful research in the field of application of viral vectors as vaccines against deadly pathogens and antibody or protein design and discovery
• Ability to generate hypothesis to test ideas, use the data set to evaluate hypothesis, and design new studies
• Ability to apply multiple cutting-edge techniques for drug screening, such as high-content imaging, microscopy, and cell-based screening
• Sound working experience in industry or biological context, and the ability to interrogate large data sets using computational tools and application of bioinformatic to dissect complicated data sets such as high throughput data a plus
• Ability for minimal travel
• Dedicated team player who can withstand the high demands of a fast-paced environment
• Excellent written and verbal communication skills are essential
• Strong planning and organizational skills
• Comfortable working independently with minimal supervision
• Highly organized, results-driven, problem solver, and collaborator
• Demonstrated ability to perform the essential duties of the position with or without accommodation

Recruitment & Staffing Agencies

Tonix does not accept agency resumes unless contacted directly by internal Tonix Talent Acquisition. Please do not forward resumes to Tonix employees or any other company location; Tonix is not responsible for any fees related to unsolicited resumes.

Compensation & Benefits

Annualized base salary ranges from $130,000 to $200,000 plus target incentive; actual salaries will vary and may be above or below this range commensurate with several factors including experience, education, training, location, and merit.

Tonix provides a comprehensive compensation and benefits package which includes:

• Medical, Dental & Vision Insurance, Basic and Voluntary Life and AD&D Insurance, Short- and Long-Term Disability Insurance, Flexible Spending Accounts, Health Savings Account, and Employee Assistance Programs
• Pet Insurance
• Retirement Savings 401k with company match and annual discretionary stock options
• Generous Paid Time Off, Sick Time, & Paid Holidays
• Career Development and Training

Tonix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, genetics, or any other characteristic protected by law. In addition to federal law requirements, Tonix complies with applicable state and local laws governing nondiscrimination in employment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Tonix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, veteran status, or any other characteristic protected by law.