Vice President, US Brand Lead

ROLE SUMMARY At Pfizer Oncology, we are committed to "Outdo Cancer" by advancing transformative medicines wherever we can make a profound difference in patients’ lives. With a leading portfolio across breast, genitourinary (GU), hematology‑oncology, gastrointestinal, and thoracic cancers, we are building a pipeline designed to change standards of care—and to do it at scale. The US Precision Medicine/Thoracic Franchise is poised for significant growth as we prepare for potential breakthrough launches, including Sigvotatug Vedotin (SGN‑B6A), an investigational antibody‑drug conjugate in development for non‑small cell lung cancer (NSCLC) and other solid tumors. This is a rare opportunity for an enterprise commercial leader to build and lead the US strategy for a high‑impact asset, shaping the go‑to‑market approach, accelerating readiness across functions, and bringing a differentiated value story to customers and patients. As Vice President, US Team Lead, you will set the US brand vision and mobilize a cross‑functional operating model spanning Commercial, Medical, Market Access, Insights & Analytics, and Global partners. You will be accountable for strategic choices, investment governance, and performance outcomes, while building an inclusive, high‑performing team that can execute with speed, rigor, and integrity in a dynamic external environment. Lead end‑to‑end US strategy from pre‑launch through launch and into sustained performance Lead the US brand team and cross‑functional launch operating model Own investment governance and outcomes , partnering closely with Finance and senior franchise leadership Translate breakthrough science into impact for patients with NSCLC and other solid tumors This is a builder's role at the moment it matters most: taking a high‑potential, highly visible oncology asset from pre‑launch through launch and into sustained impact. You will have enterprise‑level ownership‑setting the US vision, making strategic trade‑offs, and mobilizing Commercial, Medical, Market Access, Insights & Analytics, and Global partners around a single, integrated plan. For a talented, ambitious leader, this is a chance to define your legacy—direct exposure to senior franchise and enterprise stakeholders, the opportunity to hire and shape a high‑performing team, and the mandate to create a differentiated go‑to‑market story grounded in insight and evidence. If you’re energized by complexity, motivated by purpose, and driven to deliver results with integrity, this role offers the scale, autonomy, and mission to do your best work. ROLE RESPONSIBILITIES The Vice President, US Team Lead Sigvotatug Vedotin will report to the Franchise Lead, Precision Medicine/Thoracic and serve as the senior US commercial leader accountable for end‑to‑end pre‑launch, launch, and post‑launch performance. This leader sets the US brand vision, drives an integrated go‑to‑market strategy across Commercial, Medical, Market Access, and Global partners, and ensures disciplined governance, investment decisions, and execution. Build, lead, and inspire a high‑performing US brand organization, establishing clear operating rhythms, talent development plans, succession pipelines, and an inclusive team culture. Own US P&L‑aligned brand performance and all US pre‑launch and launch activities, including strategic choices, investment governance, risk mitigation, and scenario planning in partnership with Finance and the franchise leadership team. Set the US go‑to‑market strategy and integrated launch plan, aligning with Global Brand Strategy, Market Access, Medical, and field leadership to deliver a cohesive, compliant customer experience. Provide executive leadership for development of best‑in‑class HCP and patient strategy, positioning, and omnichannel content; ensure message architecture and evidence story are optimized through strong partnership with Global, Medical, and Regulatory. Identify, prioritize, and resource growth opportunities across indication expansion, segmentation, and lifecycle levers; translate insights into strategic choices with clear value cases and measurable outcomes. Lead development of annual and multi‑year strategic and operating plans, integrating HCP, patient, access, and field execution strategies grounded in customer insights and competitive dynamics. Establish performance management and analytics governance for US marketing initiatives, driving actionable insights, continuous optimization, and clear readouts to senior leadership to improve decision velocity and ROI. Lead brand financial stewardship, including Annual Operating Plan, latest estimates, and investment allocation decisions; ensure resources are deployed to maximize patient impact and business results. Champion deep customer insight generation (field, medical, analytics, payers, and key opinion leaders) and translate insights into differentiated strategy, messaging, and executional choices. Own agency ecosystem strategy and governance (AOR and specialty partners) and manage a significant A&P budget with rigorous ROI discipline, compliant review processes, and a focus on creative effectiveness and speed‑to‑market. Model and enforce a strong culture of compliance, quality, and integrity across all brand activities, ensuring adherence to Company policies, regulations, and Pfizer Values. Exhibit high performance, values‑driven approach to develop strategies, identify opportunities, and manage key issues to achieve commercial objectives. BASIC QUALIFICATIONS Candidate demonstrates a breadth of diverse leadership experiences and capabilities including influence with peers, coaching, and guiding colleagues to achieve meaningful outcomes and business impact. The successful candidate will bring enterprise‑level leadership and a track record of delivering results through scale, influence, and disciplined decision‑making. This includes leading leaders, shaping strategy across a complex matrix, and building high‑performing, values‑driven teams that thrive in ambiguity and move with urgency. Bachelor’s degree required; advanced degree (MBA/PhD/MD) preferred. 15+ years of progressive biopharma/healthcare experience, including significant US commercial leadership experience in specialty and/or oncology markets; 13+ years with MBA. Proven launch leader with end‑to‑end accountability for at least one major US product launch (pre‑launch through post‑launch performance), including omnichannel execution and field enablement. Demonstrated ability to lead through a complex matrix and partner at the executive level across Medical Affairs, Market Access, Field Leadership, Regulatory/Legal, Analytics, and Global teams. Strategic, enterprise mindset with demonstrated ability to make high‑stakes trade‑offs, build investment cases, and translate insights into clear choices and measurable outcomes. Executive presence with strong judgment, governance orientation, and ability to escalate and resolve issues quickly while maintaining alignment across senior stakeholders. Exceptional communication and influencing skills—able to synthesize complexity into clear narratives for senior leadership and cross‑functional teams. Demonstrated ability to build and run integrated operating models (cadence, governance, metrics) and lead large, cross‑functional teams to deliver at pace and with quality. Significant people leadership experience, including leading leaders (e.g., Directors/Senior Directors) and building organizational capability through hiring, coaching, and succession planning. Demonstrated financial stewardship, including ownership of large budgets and experience with forecasting, performance management, and ROI‑based investment decisions. Track record of delivering results in high‑visibility, ambiguous environments with multiple priorities, strong compliance standards, and significant reputational and financial stakes. PREFERRED QUALIFICATIONS Advanced degree (MBA/PhD/MD). Senior US brand/marketing leadership experience (e.g., US Brand Lead, Franchise Lead, or equivalent scope). Oncology launch experience strongly preferred; exceptional specialty launch leaders with clear oncology adjacency will be considered. NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Ability to travel domestically (~20%) and internationally as needed for congresses, customer engagements, and key internal meetings. Ability to work on a computer for extended periods using common applications (Outlook, Excel, PowerPoint). Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E‑Verify employer. 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