Principal Investigator (Internal Medicine)

Job Description

Job Description

About Company:

We’re people with a purpose, dedicated to advancing medical innovation and healing technology through groundbreaking research, diligent patient care and strong executive management. Our hands-on management team and medical staff are committed to rapid, efficient trials that bring life-changing drugs to market faster; our research staff brings years and years of “in the trenches” experience conducting Phase 1-4 clinical studies. And each one is dedicated to curing disease and improving individual quality of life.

MISSION STATEMENT 

At Alliance Clinical Network, our mission is to advance medical research by enrolling diverse populations in high-quality clinical trials. We are committed to maintaining the highest standards of integrity and excellence, and to ensuring that every participant receives respectful and compassionate care. We strive to build a tightly knit, supportive and collaborative environment where our team members can thrive and make meaningful contributions to human health.

About the Role:

We’re seeking an Internal Medicine physician to serve as a Principal Investigator (PI) at our Canoga Park, California research site. This position is ideal for a physician seeking a slower pace of work and very flexible, part-time hours (approximately 05–10 hours/week; typically 05–15 hours/week depending on study needs). Comprehensive PI onboarding and ongoing support are provided. You’ll provide medical oversight for clinical trials, ensure participant safety, and help generate high-quality data—without the heavy demands of a traditional clinic schedule.

Minimum Qualifications:

• MD or DO (Internal Medicine).
• Active, unrestricted California Medical Board license.
• Interest in clinical research and comfort reviewing structured clinical data.
• Strong documentation, communication, and confidentiality practices (HIPAA/PHI).

Preferred Qualifications:

• Prior experience as a PI or Sub-Investigator 
• Familiarity with ICH-GCP and FDA regulations (21 CFR Parts 50, 54, 56, 312, 812).
• Board certification in Internal Medicine; DEA registration if required by specific protocols.

Key Responsibilities:

• Serve as the study physician for assigned trials; ensure participant safety and ethical conduct.
• Review and confirm participant eligibility; oversee screening outcomes, AEs/SAEs, and retention trends.
• Perform/oversee study-specific medical assessments (histories/physicals, concomitant meds, endpoint review).
• Provide medical oversight to site staff (Sub-Investigators, CRCs, RNs, lab staff); be available for consults and safety questions.
• Collaborate with IRBs, sponsors, and CROs; join SIVs, monitoring visits, and close-out activities as needed.
• Ensure compliance with protocols, site SOPs, ICH-GCP, FDA/21 CFR, and (enter name of State here) state requirements.
• Review clinical data (labs, ECGs, vitals) and support timely safety reporting and documentation.
• Contribute to high-quality source documentation, query resolution, and continuous improvement of site processes.

Location  

On-site at Canoga Park/West Hills, California (some remote chart review/sponsor calls as studies permit). 

How to Apply  

Please send your CV and a brief note of interest (State license status, board certification, earliest start date) to our recruiting team. References should be provided upon request. 

 

EEO Statement  

Alliance Clinical Network is an Equal Opportunity Employer/Contracting Partner. We celebrate diversity and are committed to an inclusive environment for all clinicians and staff. 

Accessibility/Accommodation  

If you require reasonable accommodation to apply or interview, please let us know.