Principal Software Engineer

Principal Software Engineer

The Regeneron Genetics Center is one of the largest human genetics sequencing programs in the world. We study human DNA at massive scale to understand why diseases happen and how we can stop them. Using genetics to improve human health, our research has contributed directly to medicines helping patients today.

The RGC IT team builds and maintains shared services, platform tooling, and APIs that our research teams depend on. We approach development with an AI-first mindset, utilizing LLM-powered tooling to move faster, explore more ideas and quickly turn complex problems into working solutions for our scientists.

A typical day as a Principal Software Engineer, you'll contribute to:

• API and service development across a shared platform that research teams use to access and work with large-scale genetic data.
• Cloud-based data pipeline work on AWS, keeping high-volume genomic data moving reliably and performantly.
• Integrating and applying AI tooling across development workflows — from LLM-assisted coding and review to building AI-powered capabilities into the platform itself.
• Working directly with scientists and engineers to understand requirements and deliver meaningful solutions to improve our scientific discovery process.

This role might be for you if you have:

• Strong fundamentals at the API and data layer. You've built production APIs, integration services, and pipelines in the cloud as microservices.
• Comfortable with AI-first development. You use tools like Claude Code as a core part of how you work — not occasionally, but throughout planning, implementation, and review.
• Technical depth across the stack. API design patterns, distributed systems, cloud-native development on AWS — you can contribute without needing everything handed to you.
• Works well as part of a team. Decisions here are collaborative. You do good work in that kind of environment.
• Takes quality seriously. You write things that can be tested and maintained, and you know why that matters at scale.

To be considered for this opportunity, you must have a Bachelor's Degree or higher with at least 6 years of relevant IT experience building cloud-native applications. Candidates must have hands-on experience with:

• Languages & Runtimes: Python, TypeScript
• API & Integration: REST API design and development, service integration patterns
• AI Tooling: LLM-assisted development tools (e.g. Claude Code, GitHub Copilot), AI/ML service integration
• Data & Databases: PostgreSQL or MySQL, Redshift or Snowflake, ETL orchestration
• Infrastructure: Docker, AWS cloud services

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit For other countries' specific benefits, please speak to your recruiter.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually): $128,600.00 - $210,000.00