Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Executive Director, Pipeline Clinical Lead

$294.48k - $386.51k

Legend Biotech US

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking an Executive Director, Pipeline Clinical Lead as part of the Clinical Development team based in Somerset, NJ .

Role Overview

The Pipeline Clinical Lead is a senior clinical development leader accountable for the scientific and medical direction of early stage clinical programs. This role provides strategic and operational leadership across first in human through proof of concept studies, with accountability for clinical strategy, trial design, execution, interpretation, and regulatory interactions.

The Pipeline Clinical Lead will lead and develop a team of physicians and scientists, work closely with cross functional partners, and collaborate with external development partners and investigators. Deep expertise in clinical trial design, regulatory frameworks, and compliance in drug development-ideally within cell therapy-is essential.

This role requires strong scientific judgment, leadership presence, and a hands on approach in a fast paced, entrepreneurial environment, with a clear focus on patient safety and clinical impact.

Key Responsibilities

Clinical Development Leadership
  • Serve as clinical science lead for early stage programs (pre IND through Phase 1/2), including study design, execution, data interpretation, and reporting.
  • Define and integrate clinical strategies, including PK/PD, biomarkers, diagnostics, and translational approaches, particularly for cell and gene therapies.
  • Provide clinical input into asset selection, review of preclinical data, and development path decisions.
Regulatory & Compliance
  • Lead or support IND preparation and amendments, clinical sections of regulatory submissions, and responses to health authority questions.
  • Represent the clinical function in pre IND, IND, and (as applicable) BLA/MAA interactions with regulatory agencies.
  • Champion patient safety, ethical conduct, and compliance with GCP, corporate policies, and global healthcare regulations.
Cross Functional & External Collaboration
  • Partner closely with Clinical Operations, Biostatistics, Regulatory Affairs, Early Discovery,
  • Manufacturing, Biomarkers, and Pharmacovigilance to ensure integrated program delivery.
  • Collaborate with external development partners, academic investigators, KOLs, and study sites.
  • Act as a credible scientific and clinical representative for programs in internal governance and external forums.
People & Matrix Leadership
  • Provide direct line management and mentorship for Medical Directors, Clinical Research Scientists, Medical Writing, Clinical Program management and other clinical staff as applicable.
  • Lead effectively in a matrix environment, anticipating cross functional needs and proactively resolving conflicts or risks.
  • Contribute clinical leadership to business development, due diligence, and partnership activities when required.
Requirements
  • MD or MD PhD (or equivalent) with US board certification or international equivalent.
  • ≥8 years of clinical development experience in industry and/or academia, with demonstrated leadership in hematology/oncology.
  • Proven experience designing and executing clinical trials from first in human through registrational stages.
  • Prior involvement with IND submissions; experience with BLA/MAA filings and health authority meetings strongly preferred.
  • Cell therapy and/or CAR T clinical development experience highly desirable IT Skills.
  • Strong scientific judgment with the ability to navigate complex clinical and regulatory challenges.
  • Demonstrated ability to lead cross functional and geographically distributed teams in a matrix environment.
  • Excellent written and oral communication skills, including protocol writing, regulatory documents, publications, and senior level presentations.
  • Highly collaborative, influential leader with the ability to represent programs with credibility and confidence.
  • Hands on, execution oriented mindset with strong organizational and analytical skills.
  • Willingness to travel up to 15-20%.

#Li-AS1

#Li-Hybrid

The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.

Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles.

Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Pay Range (Base Pay):


$294,483-$386,511 USD

Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

For information related to our privacy notice, please review: Legend Biotech Privacy Notice.
Vacancy posted 5 days ago
Similar jobs that could be interesting for youBased on the Executive Director, Pipeline Clinical Lead in Somerset, NJ vacancy
  •  ...Executive Director, Clinical Program Lead About the Company Globally-recognized biopharmaceutical company Industry Biotechnology Type Public Company Founded 1988 Employees 1001-5000 Categories Pharmaceuticals Medicine Manufacturing... 
    Suggested

    Confidential

    Bridgewater, NJ
    3 days ago
  •  ...Executive Medical Director, Hematology The Executive Medical Director, Hematology, will provide overall clinical scientific leadership for the cell therapy program and have responsibility...  ...directly to the VP, Therapeutic Area Lead, Hematology. A typical day in the... 
    Suggested

    Regeneron

    Warren, NJ
    2 days ago
  • $70k - $250k

     ...Microsoft Solutions Executive The Microsoft Solutions Executive will drive growth and build onto the rapidly growing Microsoft practice...  ...Solutions Executive is responsible for generating and driving pipeline by understanding customer needs and positioning company... 
    Pipeline
    Base plus commission
    Work experience placement
    Work at office
    Flexible hours

    SHI

    Somerset, NJ
    3 days ago
  • JAG Physical Therapy in New Brunswick, NJ seeks a Clinical Director to oversee operations of an outpatient rehab clinic. Responsibilities include ensuring compliance, patient care, and meeting clinic goals. Qualified candidates must have a Bachelor’s or Master’s degree,... 
    Suggested
    Relocation package

    JAG Physical Therapy

    New Brunswick, NJ
    2 days ago
  •  ...Officer (CSO). The CSO will lead and oversee the global Research...  ..., you will work closely with executive leadership, product...  ...delivering multiple compounds into clinic development. You should be skilled...  ...and risk-balanced pipeline of therapeutics. Develop and... 
    Pipeline
    Permanent employment
    Full time
    Temporary work
    For contractors
    Local area
    Worldwide
    Flexible hours

    Legend Biotech US

    Somerset, NJ
    2 days ago
  •  ...Medical Officer as part of the Clinical Development team based in...  ...advanced manufacturing and global execution capabilities, Legend Biotech...  ...vision for the company's pipeline. Reporting to President of...  ...key external stakeholders to lead the clinical development program... 
    Pipeline
    Worldwide

    Legend Biotech

    Somerset, NJ
    2 days ago
  • $232k - $401.35k

     ...their merit. Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function:...  ...Johnson & Johnson (J&J) is seeking an Executive Director, Clinical Leader - Neuropsychiatry to...  ...-functional Clinical Team (CT). The CL leads the team to develop products in a timely... 
    Full time
    Local area
    Immediate start

    Johnson & Johnson Innovative Medicine

    Raritan, NJ
    3 days ago
  •  ...Description Executive Director, Business Development The...  ...stakeholders at all levels. Leads the orchestration of tailored...  ...based on client needs, pipeline dynamics, and strategic goals...  ...differentiated value proposition, clinical and commercial capabilities,... 
    Pipeline
    Work at office
    Immediate start
    Remote work
    Shift work

    Taylor Strategy Partners

    Bridgewater, NJ
    2 days ago
  • $163k - $245k

     ...Description Lantheus (NASDAQ: LNTH) is the leading radiopharmaceutical -focused...  ...we’re expanding our portfolio and pipeline across oncology, neurology and...  ...role The Radiopharmaceutical Clinical Applications Associate Director will be responsible for leading the... 
    Pipeline
    Local area
    Remote work

    Lantheus Medical Imaging Inc

    Somerset, NJ
    19 days ago
  • $270k

     ...are looking for an experienced Project executive to join a well established general contractor...  ...market conditions. They have a healthy pipeline at the moment with new projects across...  ...0,000.00-$140,000.00 2 weeks ago Senior Director, Capital Project Management We’re... 
    Pipeline
    Full time
    Contract work
    For contractors
    Work at office

    TYG

    Edison, NJ
    3 days ago
  • ADLAI NORTYE USA INC in North Brunswick Township, NJ, seeks a Manager for Clinical Pharmacology to lead clinical trials and analyses. The role involves collaboration with multiple departments to support oncology research and drug development. The ideal candidate has a PhD... 

    ADLAI NORTYE USA INC

    North Brunswick, NJ
    5 days ago
  •  ...Executive Director About the Company Globally-renowned philanthropic foundation Industry Non-Profit Organization Management...  ...the Role The Company is seeking an Executive Director to lead its philanthropic partner, the Foundation. The successful... 

    Confidential

    Piscataway, NJ
    4 days ago
  • $250k - $315k

    Medical Director - Rare Endocrine Disorders Facility:...  ...About the Department The Clinical, Medical and...  ...as the medical content lead for a Therapeutic Area...  ...strategic development and execution within a therapeutic area...  ...Teams for in-line and pipeline products in... 
    Pipeline
    Local area
    Remote work
    Home office
    Flexible hours
    Night shift

    Novo Nordisk A/S

    Plainsboro, NJ
    2 days ago
  • Rutgers University in New Brunswick, NJ, is seeking a Myeloma Clinical Scholar, Faculty Physician at the Associate/Professor level. This clinical research position focuses on myeloma, involving original research, teaching medical students and fellows, and potential leadership... 

    Rutgers University

    New Brunswick, NJ
    5 days ago
  • $275k

     ...join a dynamic and expanding program with clinical, academic, and research components. This...  ...education. \n This is a unique opportunity to lead a collaborative, multidisciplinary...  ...disorders, and serves as the Director of the Comprehensive Stroke Center. \n... 
    Traineeship
    Flexible hours

    RWJBarnabas Health

    New Brunswick, NJ
    12 days ago
  •  ...distinguished, dynamic and collaborative leader with a strong clinical and academic foundation to serve as its next Academic Chief of...  ...clinical and operational support and expertise of one of the nations leading health systems.  New Brunswick is a desirable region of the... 

    RWJBarnabas Health

    New Brunswick, NJ
    7 days ago
  • Katalyst CRO in Edison, New Jersey, seeks an experienced clinical data management leader. The role involves overseeing data collection processes...  ...communication skills. This position offers an opportunity to lead data management efforts for clinical development programs. #J-1... 

    Katalyst CRO

    Edison, NJ
    4 days ago
  • Creative Solutions Services, LLC is seeking an experienced leader in Clinical Data Management to oversee clinical systems for data collection and manage CDM activities. This role requires a Bachelor’s Degree in a scientific discipline along with 9 years of industry experience... 

    Creative Solutions Services, LLC

    Edison, NJ
    3 days ago
  • $120k - $190k

     ...Job Description \n Job Title: Nurse Practitioner Lead \n Location: Emergency Medicine Associates \n Department Name: Hospitalist...  ...\n   \n Knowledge and Skills: \n -Medical and broad based clinical emergency medicine knowledge \n -Strong verbal and written... 
    Work experience placement
    Shift work
    Night shift
    Weekend work
    Weekday work

    RWJBarnabas Health

    New Brunswick, NJ
    17 days ago
  • The Association-American Cancer Institute seeks an Associate Director of Clinical Trials Finance to oversee financial strategies and budget management for clinical trials. This role will involve leading financial negotiations and managing internal teams while ensuring compliance... 

    Association-American Cancer Institute

    New Brunswick, NJ
    5 days ago
  • $83.2k - $208k

    Penn Medicine, University of Pennsylvania Health System seeks an experienced Clinical Coordinator Nurse Midwife in Plainsboro Township, NJ. The role involves providing independent and collaborative midwifery care, ensuring compliance with regulations, and assisting with... 

    Penn Medicine, University of Pennsylvania Health System

    Plainsboro, NJ
    1 day ago
  • $270k

     ...Laboratory Medicine, are seeking a Medical Director of Pathology/Transfusion Medicine to...  ...position offers an opportunity to guide clinical operations, advance research, and play a...  ...experience. \n Position Highlights \n · Lead and collaborate with the... 

    RWJBarnabas Health

    New Brunswick, NJ
    27 days ago
  • $400k

     ...Wood Johnson Medical School, invites applications for a Medical Director in the Department of Pathology and Laboratory Medicine, Robert...  ...Hospital-Somerset. The Department is responsible for all anatomic and clinical laboratory services at Robert Wood Johnson University Hospital-... 
    Relocation package

    RWJBarnabas Health

    Somerset, NJ
    4 days ago
  • $315k

     ...case managers on site \n Opportunities to work in the inpatient setting, PESS unit, or as a consult liaison depending on your clinical preference \n Career growth and close team partnership \n \n About RWJ University Hospital Somerset: \n At RWJUH Somerset... 
    Full time
    Immediate start

    RWJBarnabas Health

    Somerset, NJ
    14 days ago
  • A leading academic institution is seeking a Research Nurse Clinician to ensure the successful and safe conduct of clinical trials. Responsibilities include protocol activation, patient accrual, and clinical nursing duties. The ideal candidate will have a Bachelor's Degree... 

    Rutgers University

    New Brunswick, NJ
    1 day ago
  • Saint Peter's Healthcare System in New Brunswick, New Jersey is seeking a compassionate Research RN to join our award-winning nursing team. The role involves implementing research protocols, maintaining organization of study files, and participating in data collection and...

    Saint Peter's Healthcare System

    New Brunswick, NJ
    5 days ago
  •  ..., faculty recruitment and development, scholarly activity, and clinical and teaching excellence. The new Chief will have the opportunity...  ...and operational support and expertise of one of the nation's leading health systems. New Brunswick is a desirable region of the Northeast... 

    RWJBarnabas Health

    New Brunswick, NJ
    1 day ago
  • A leading substance abuse organization is seeking a Clinical Director for its Intensive Outpatient Counseling program in New Jersey. The role involves supervising clinical staff, ensuring high-quality care, and coordinating professional development. Candidates must have... 
    Visa sponsorship

    Evolve Treatment Centers

    Middlesex, NJ
    2 days ago
  • Everest Clinical Research Services Inc. is seeking a Senior Clinical Data Manager for their Bridgewater, New Jersey location, with remote work options available. The role includes developing and maintaining project plans, overseeing data management deliverables, and providing... 
    Remote job

    Everest Clinical Research Services Inc.

    Bridgewater, NJ
    5 days ago
  • $310k

     ...Pathology and Laboratory Medicine, are seeking a Director (Chief) for the Division of Anatomic...  ...role provides the opportunity to oversee clinical, research, and academic programs, guide...  .... \n Position Highlights \n · Lead and manage all aspects of the Division of... 

    RWJBarnabas Health

    New Brunswick, NJ
    27 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Executive Director, Pipeline Clinical Lead. Be the first to apply!