Staff Software Engineer

We're a moonshot company pushing the boundaries of biotech and drug discovery. Born out of Yale, we aim to radically rethink the traditional R&D model—and we’re backed by some of the most forward-thinking institutions out there. We won the ARPA-H award (think DARPA for health), the same kind of program that gave rise to Siri, the Internet (ARPANET), and GPS. Backing our mission: $20M in VC funding, $30M in government contracts. We’re just getting started—and we’d love for you to be part of it. About the role Revalia is pioneering Human Data Trials — a new paradigm for accelerating translational medicine by linking donated human organs to cutting‑edge research. Our platform provides biotech, pharma, and medtech innovators with unparalleled access to human biology at scale, reducing reliance on animal models and speeding the path to patients. We are seeking a highly skilled backend/full‑stack engineer who doesn’t just write code—you architect elegant solutions. You have immense hands‑on experience with Python and FastAPI, and you understand how to build systems that scale. You’re proficient with modern AI coding tools and use them strategically to enhance your productivity while maintaining high standards for code quality and security. You take pride in crafting performant, reliable backend services and collaborating effectively with cross‑functional teams. You’re curious, adaptable, and excited about staying at the forefront of backend innovation while maintaining strong fundamentals in distributed systems and cloud architecture. As a Staff Engineer, you will be responsible for architecting and implementing backend systems and full‑stack features that power our web applications. You’ll collaborate closely with product managers, designers, and frontend engineers to deliver reliable, performant services that scale with our business. Your technical expertise in Python/FastAPI and AWS infrastructure, combined with proficiency in AI coding tools, will enable you to write efficient, maintainable code at scale while staying at the forefront of backend development practices. Location This position is fully remote with the expectation to travel quarterly to our office in New Haven, CT. We do not provide work visa sponsorship. This position is only open to candidates who are legally eligible to work in the United States without sponsorship. Culture Requirements Role model the RevaliaBio’s Company Values of world‑class collaboration, cultivating deep trust, relentless adaptability, and to persevere with uncommon grit. Display high levels of personal integrity and be able to express opinions or concerns directly and without triangulation, demonstrating honesty, openness, and a positive outlook at all times. Seek to promote collaboration and be curious (and not judgmental) about opposing opinions. Ability to adapt to changing business needs or personal development opportunities. Able to fully embrace feedback and training to continuously improve performance and relationships. Display determination and perseverance to problem‑solve, create, innovate, and develop. Demonstrate commitment to own personal growth and development. Be “all‑in” when participating in company activities and programs related to personal and professional development and training. Commitment to the growth and development of their team including participation in 360 reviews where requested. Soft Skill Requirements Excellent communication and collaboration abilities, with a proven track record of working effectively in team environments Strong problem‑solving skills with the ability to break down complex requirements into manageable, testable solutions Attention to detail and commitment to code quality and system reliability Self‑motivated with an intrinsic drive to learn and adapt to emerging technologies Proactive in identifying and addressing technical debt and suggesting architectural improvements Strong time management and ability to balance multiple priorities in a fast‑paced environment Professional work experience in DevOps, security, and cloud infrastructure – We use GitHub Actions , Docker, and AWS CDK extensively Technical Skill Requirements Advanced proficiency in Python , including modern Python practices, async programming, and framework expertise Strong expertise in FastAPI or similar Python web frameworks (Django, Flask), including dependency injection, middleware, and OpenAPI/Swagger integration Deep experience with PostgreSQL , including schema design, query optimization, indexing strategies, and migrations Solid understanding of AWS services , particularly RDS, Lambda, S3, SQS/SNS, and related infrastructure Hands‑on experience with AI coding tools and AI‑assisted development workflows (mandatory) Strong knowledge of RESTful API design principles, versioning strategies, and documentation standards Solid knowledge of version control systems , specifically Git and GitHub, with collaborative workflows Experience with containerization using Docker and container orchestration concepts Familiarity with CI/CD pipelines , particularly GitHub Actions Knowledge of testing frameworks (pytest, unittest) and testing strategies (unit, integration, end‑to‑end) Understanding of security best practices for web applications, including authentication, authorization, and data protection Bonus Skills Experience with AWS CDK or other infrastructure‑as‑code tools (Terraform, Pulumi) Familiarity with event‑driven architectures and microservices patterns Experience with GraphQL API development Knowledge of caching strategies using Redis or similar technologies Experience with data pipelines and ETL processes Familiarity with observability tools (DataDog, CloudWatch, Sentry, etc.) Contribution to open‑source projects related to backend development Experience with message queues and distributed systems patterns Background or exposure to medical systems/processes Experience with Next.js or React for full‑stack contributions Responsibilities Design and implement scalable backend services using Python and FastAPI, ensuring high performance, reliability, and maintainability Architect database solutions with PostgreSQL (RDS), including schema design, query optimization, and data modeling best practices Build and maintain RESTful APIs that integrate seamlessly with frontend applications and external services Develop serverless solutions using AWS Lambda for event‑driven architectures and background processing Implement messaging and event systems using AWS SQS/SNS for asynchronous workflows and service decoupling Contribute to infrastructure as code using AWS CDK, supporting deployment pipelines and cloud architecture Write clean, scalable, and maintainable code following best practices, design patterns, and established coding standards Collaborate effectively with cross‑functional teams including designers, product managers, and frontend engineers to refine requirements and deliver high‑quality solutions Conduct and participate in code reviews to ensure code quality, knowledge sharing, and adherence to team standards Debug and troubleshoot backend issues, utilizing monitoring tools, logging, and AI‑assisted debugging techniques Stay current with industry trends, emerging technologies, and best practices in backend and full‑stack development Use AI coding tools (e.g., Cursor, GitHub Copilot, ChatGPT) to enhance productivity, validate generated code, and accelerate development cycles Qualifications 5+ years of professional experience in backend or full‑stack development with a proven track record of shipping production‑quality code Compensation, Benefits, and Diversity Commitment Our compensation structure includes a base and semi‑annual bonus. RevaliaBio operates a growth culture focused on High Performance Teams and individual personal development. Along with monthly coaching, we provide extensive opportunities for professional development, training and mentoring. RevaliaBio provides comprehensive benefits including Health, Dental, Vision, Retirement, Disability, and a wellness program available on day one of employment. Full‑time employees are eligible for up to 5 paid sick days and 23 PTO days per calendar year, excluding national holidays. RevaliaBio acknowledges and celebrates the diversity of our workforce, is dedicated to creating an equitable workplace, is committed to fostering an inclusive environment, and aims to create a workplace culture where every individual feels a sense of belonging. We are an equal opportunity employer and do not discriminate on the basis of race, religion, color, national origin, sex, sexual orientation, gender, gender identity or expression, age, disability, or genetic makeup. For individuals with disabilities who would like to request accommodations, please email View email address on click.appcast.io. #J-18808-Ljbffr Revalia Bio, Inc.