Senior Principal Scientist, Preclinical Safety & Translational Sciences-Translational PharmacokineticsPharmacodynamics

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacokinetics & Pharmacometrics

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego California United States of America Spring House Pennsylvania United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at

Purpose: The Senior Principal Scientist will be a key member of discovery project teams and interact closely with biology chemistry and other drug metabolism and pharmacokinetic (DMPK) project members to help craft the most appropriate preclinical and early clinical studies and the associated quantitative model-based analyses to advise candidate selection and dosing recommendations. Modeling approaches used may include physiologically-based pharmacokinetic modeling mechanistic PK/PD modeling and/or systems pharmacology modeling to help (a) predict preclinical and clinical PK profiles (b) quantify exposure/ response relationships for target engagement biomarkers efficacy and potential adverse effects and (c) guide in vivo and in vitro experimental designs that will be most informative for modeling.

We are searching for the best talent for a Senior Principal Scientist Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics to be located in Spring House PA or La Jolla CA.

You will be responsible for:

• Applying Pharmacokinetic/Pharmacodynamic (PK/PD) modeling to drive project team decisions from early discovery through early clinical studies.
  
• Contributing to guide modeling and simulation strategies within the organization.

Qualifications / Requirements:

Education:

• PhD in Pharmacology Engineering Mathematics Physics or a related field with 6 years of relevant industry experience OR a Masters degree with 8 years of relevant industry experience is required.

Experience and Skills:

• Strong familiarity with principles of pharmacokinetics and pharmacodynamics and experience performing PK and/or PK/PD modeling is preferred.
  
• Proven skills in mathematical modeling and simulation supported by peer-reviewed publications is highly desired.
  
• Excellent interpersonal organizational oral/written communication and teamwork skills are required.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

If you are under 18 years of age you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment as well as get a parents consent for the background check.

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Required Skills:

Preferred Skills:

Clinical Pharmacology Clinical Trials Operations Consulting Drug Discovery Development Industry Analysis Pharmacodynamics Pharmacokinetics Pharmacology Pharmacometrics Program Management Report Writing Researching Research Proposals Scientific Research Tactical Planning Technical Credibility

The anticipated base pay range for this position is :

$137000.00 - $235750.00

Additional Description for Pay Transparency:

Required Experience:

Staff IC