Research Scientist, Protein Sciences

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Contributes to the discovery and development of novel therapeutics for the treatment of neurodegenerative diseases. Supports our discovery organization focused on sample preparation for in vitro and in vivo studies to advance projects from discovery to development. Works with the Protein Sciences team in preparing samples & SOPs/COAs for preclinical studies. Supports the scientists in the group with primary or secondary purifications and early analytical characterizations. Work closely with our Informatics group to maintain sample inventory and upload final QC documents. Key Accountabilities/Core Job Responsibilities: Work closely with members of the Protein Sciences team to prepare large-molecule biotherapeutics for preclinical in vivo and in vitro studies, including analytics, inventory and storage, and shipment to external CROs. Prepare standard operating procedures (SOPs) and Certificates of Analysis (COAs) for key biotherapeutic candidates. Deliver purified biotherapeutic proteins to project teams in support of study and development timelines. Collaborate with Bioinformatics and cross-functional team members to establish and continuously improve tools for sample registration and tracking. Maintain accurate and well-organized documentation, including records in Electronic Lab Notebooks (ELNs). Communicate results proactively and clearly with team members, and address questions in a timely manner. Coordinate activities with functional groups and project teams to support timelines and operational efficiency. Qualifications/Skills: Typically, Bachelor’s degree in a related scientific discipline with 0–2 years of relevant experience. Strong organizational skills with close attention to detail. Working knowledge of PowerPoint, Excel, and Word. General understanding of protein and antibody biochemical and/or biophysical characterization. Completion of at least one laboratory course in biology, chemistry, or biophysics, or equivalent experience in a laboratory environment. Hands-on experience with biochemistry techniques, including protein quantitation, protein purification, and/or biophysical or biochemical assays. Proficiency with standard office and scientific software (e.g., Excel, Word, PowerPoint) Salary Range: $90,000.00 to $117,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class. “Life at Denali” is a living reflection of our values: trust, unity, grit and growth. These are not just words we share—they shape how we show up, collaborate and push boundaries together. From the lab to the community, across functions and milestones, our culture thrives on shared purpose and relentless pursuit.