Senior Biostatistician, Clinical Trial Design

Job Description

Job Description

MyOme is a clinical whole genome analysis company helping individuals and families understand their risk for disease. As a leader in polygenic and AI-based integrative risk modeling, we combine genome sequencing with AI-driven analytics and clinical data to deliver a lifetime of clinically meaningful, actionable insights, from proactive risk assessment to rare disease diagnosis. Our laboratory is CLIA-certified and CAP-accredited, and we're based in Menlo Park, California.

Our team brings together scientists, engineers, clinicians, and professionals across disciplines, united by a shared purpose: making genomic insight a routine part of everyday healthcare. We put patients first and hold ourselves to the scientific and clinical rigor that families and their clinicians depend on.

Joining MyOme means contributing your expertise to work that matters for patients and families. Whether you're advancing our science and technology, supporting the clinicians and patients we serve, or strengthening our operations, you'll help turn genomic discoveries into better care.

Position Overview:

We're seeking a senior biostatistician with a strong background in clinical trials design and familiarity with genetics for clinical risk prediction. You'll own trial design, estimands, and Statistical Analysis Plans, and you'll work directly with the data using reproducible code. This is a key role on a small, self-sufficient, and versatile team: the successful candidate will roll up their sleeves to deliver the analysis end-to-end, transforming ambiguous questions into defensible, reproducible, and impactful findings.

What You'll Do:

• Design prospective, biomarker-stratified studies to demonstrate the clinical utility of our genetic models; define estimands, endpoints, and analysis strategies.
• Develop and execute Statistical Analysis Plans, sample-size and power calculations, and primary, sensitivity, and subgroup analyses consistent with ICH E9 / E9(R1).
• Pull, clean, and analyze complex data (e.g. biobank cohorts (UK Biobank, All of Us), EHR extracts, registries) in reproducible and well-structured code.
• Collaborate with the statistical genetics team on calibration and ancestry-portability questions that affect trial design.
• Apply survival, longitudinal, and causal/observational methods to real-world evidence that complements trial data.
• Partner with medical, regulatory, and clinical operations teams and support trial-related regulatory interactions.

What You'll Ne ed:

• Ph.D. in Biostatistics or a closely related quantitative field and 4+ years of relevant industry experience.
• Direct experience leading the statistical strategy for prospective clinical trials end-to-end: SAP authorship, sample-size/power, estimands, and working command of ICH E9.
• Working familiarity with genetic risk assessment in clinical use, including polygenic or monogenic risk, through a diagnostic lab, screening program, or clinical trial.
• Demonstrated ability to take raw, poorly-structured data and produce clean, reproducible analyses independently.
• Proficiency in Python and/or R, version control (Git), and large genomic/clinical datasets in cloud environments (AWS / GCP / DNAnexus).
• Survival and longitudinal modeling; causal inference for observational data.
• Strong written and verbal communication skills to communicate complex statistical concepts to non-technical audiences.

Preferred / Bonus Qualifications:

• Experience with diagnostic-product trials. 
• Experience in a start-up environment.
• Strong publication record that demonstrates initiative and scientific independence.
• Direct work on a genetics clinical-utility or decision-impact study.
• Regulatory trial experience (IDE, FDA interactions) or clinical validation for diagnostics / SaMD

Location, Compensation, and Benefits:

• Location: Hybrid, 2–3 days onsite at our Menlo Park, CA office; Bay Area candidates preferred. Remote in the US considered for the right candidate.
• Compensation: Annual salary range of $160,000 - $180,000, commensurate with experience. This role is also eligible for equity. 

San Francisco Bay Area pay range

$160,000—$180,000 USD

Benefits:

• Comprehensive healthcare coverage (Health, Dental, and Vision)
• 401K
• Professional development opportunities
• Company-sponsored off-sites and team meals during in-person meetings
• Direct access to company leadership and the opportunity for career growth

Equal Employment Opportunity and Reasonable Accommodations

MyOme is an equal opportunity employer. We make employment decisions without regard to race, color, ancestry, national origin, religion, age, sex (including pregnancy, childbirth, breastfeeding, and related medical conditions), gender, gender identity or expression, sexual orientation, marital status, physical or mental disability, medical condition, genetic information, military or veteran status, reproductive health decision-making, or any other characteristic protected by applicable law. MyOme provides reasonable accommodations to qualified applicants with disabilities and as otherwise required by law. To request an accommodation during the application or interview process, please contact View email address on ziprecruiter.com.

Why Work at MyOme?

Join us if you:

• Want to make an impact at the intersection of healthcare and technology, changing the way people engage with their health at the genetic level
• Enjoy rolling up your sleeves, taking initiative, and being empowered to lead
• Value humility, transparency, and collaborative problem-solving
• Thrive in fast-moving, dynamic environments with smart, driven teammates
• Appreciate competitive compensation, meaningful equity, and excellent benefits

Learn More: myome.com