Supply Chain Manager

Overview We are seeking an individual for the role of Manager - Clinical Supply Chain, Operations. In this position, you will play a pivotal role in ensuring reliable, compliant execution of clinical supply across programs, supporting Alnylam's growing pipeline and patient needs. Your focus will be on overseeing end-to-end clinical supply execution activities across assigned protocols, ensuring timely delivery of materials to sites and patients. You will partner closely with cross‑functional teams including Clinical Operations, Quality Assurance, Regulatory Affairs, and external vendors to execute clinical trials effectively. Overall, you will be accountable for ensuring uninterrupted supply, managing operational risks, and delivering execution excellence across protocols in a dynamic environment. This position is hybrid and will be primarily located in the Alnylam Cambridge office. Responsibilities Responsible for end‑to‑end execution of clinical supply activities including IRT, packaging, labeling, distribution, inventory management, returns, destruction, and study closeout Ensure protocol milestones are met on time and in full (e.g., FPI, SIV readiness, on‑time delivery to sites/patients) Partner cross‑functionally with Clinical Operations, QA, Regulatory, and CMOs to ensure efficient and compliant execution Manage and elevate day‑to‑day execution risks including delays, deviations, and supply disruptions with clear escalation and mitigation Oversee temperature excursions and supply deviations ensuring appropriate documentation and resolution Ensure execution activities are compliant, well‑documented, and inspection‑ready Maintain visibility to inventory levels and supply availability across programs Contribute to continuous improvement of execution processes, tools, and ways of working Train fellow trial leads Qualifications B.Sc. in a scientific field or Supply Chain Management or related field 5+ years of direct Clinical Supply Chain experience globally Demonstrated knowledge of clinical supply chain packaging, labeling, inventory management, global distribution Strong understanding of clinical trial operations and drug development lifecycle Foundational knowledge of GMP / GxP / GCP and global regulatory requirements (FDA, EU, etc.) Experience with systems/tools (IRT/IXRS, inventory systems, Excel, Smartsheet, ERP) Risk identification, assessment, and mitigation Project management across multiple studies/programs Vendor / CMO / CRO management and oversight Budget tracking, cost control, and financial oversight of protocols Problem‑solving and risk‑based decision making Proficient knowledge of MS Office (Excel, PowerPoint, Visio, Project, etc) Excellent communication, attention to detail, collaboration, ability to manage complex challenges, and influencing skills U.S. Pay Range $122,400.00 - $165,600.00 The pay range reflects the full‑time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short‑term incentive award (e.g., bonus or sales incentive) and an annual long‑term incentive award (e.g., equity). Benefits Alnylam's robust Total Rewards package is designed to support your overall health and well‑being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company‑wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well‑being reflects our belief that caring for our people fuels the impact we create together. Equal Opportunity Employer At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E‑Verify Employer. #J-18808-Ljbffr